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30.06.2018 | Original Article - Tumor - Meningioma | Ausgabe 9/2018 Open Access

Acta Neurochirurgica 9/2018

Predictors of early progression of surgically treated atypical meningiomas

Zeitschrift:
Acta Neurochirurgica > Ausgabe 9/2018
Autoren:
Karol P. Budohoski, James Clerkin, Christopher P. Millward, Philip J. O’Halloran, Mueez Waqar, Seamus Looby, Adam M. H. Young, Mathew R. Guilfoyle, Diana Fitzroll, Abel Devadass, Kieren Allinson, Michael Farrell, Mohsen Javadpour, Michael D. Jenkinson, Thomas Santarius, Ramez W. Kirollos
Wichtige Hinweise
This article is part of the Topical Collection on Vascular Tumor-Meningioma

Abstract

Background

Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit a high recurrence rate, some pursue a more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors that predict risk of early tumour progression and to determine whether early progression is related to outcome.

Methods

Adult patients with WHO grade II meningioma treated in three regional referral centres between 2007 and 2014 were included. MRI and pathology characteristics were assessed. Gross total resection (GTR) was defined as Simpson 1–3. Recurrence was classified into early and late (≤ 24 vs. > 24 months).

Results

Among the 220 cases, 37 (16.8%) patients progressed within 24 months of operation. Independent predictors of early progression were subtotal resection (STR) (p = 0.005), parafalcine/parasagittal location (p = 0.015), peritumoural oedema (p = 0.027) and mitotic index (MI) > 7 (p = 0.007). Adjuvant radiotherapy was negatively associated with early recurrence (p = 0.046). Thirty-two per cent of patients with residual tumour and 26% after GTR received adjuvant radiotherapy. There was a significantly lower proportion of favourable outcomes at last follow-up (mRS 0–1) in patients with early recurrence (p = 0.001).

Conclusions

Atypical meningiomas are a heterogeneous group of tumours with 16.8% patients having recurrence within 24 months of surgery. Residual tumour, parafalcine/parasagittal location, peritumoural oedema and a MI > 7 were all independently associated with early recurrence. As administration of adjuvant radiotherapy was not protocolised in this cohort, any conclusions about benefits of irradiation of WHO grade II meningiomas should be viewed with caution. Patients with early recurrence had worse neurological outcome. While histological and imaging characteristics provide some prognostic value, further molecular characterisation of atypical meningiomas is warranted to aid clinical decision making.

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