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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Pulmonary Medicine 1/2015

Predictors of microbial agents in dust and respiratory health in the Ecrhs

Zeitschrift:
BMC Pulmonary Medicine > Ausgabe 1/2015
Autoren:
Christina Tischer, Jan-Paul Zock, Maria Valkonen, Gert Doekes, Stefano Guerra, Dick Heederik, Deborah Jarvis, Dan Norbäck, Mario Olivieri, Jordi Sunyer, Cecilie Svanes, Martin Täubel, Elisabeth Thiering, Giuseppe Verlato, Anne Hyvärinen, Joachim Heinrich
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12890-015-0042-y) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.
In the past five years have you received reimbursements, fees, funding, or salary from an organization that may in any way gain or lose financially from the publication of this manuscript, either now or in the future? Is such an organization financing this manuscript (including the article-processing charge)? If so, please specify. NO
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Do you have any other financial competing interests? If so, please specify. NO
Are there any non-financial competing interests (political, personal, religious, ideological, academic, intellectual, commercial or any other) to declare in relation to this manuscript? NO

Authors’ contributions

(Co-) author contribution CT First author, statistical analysis, manuscript preparation, manuscript revision, JH, AH Study design, provision of data, comments to the draft, JPZ Provision of the data (ß-glucan), study design, critical revision of the manuscript, MV.Measurements microbial markers, critical revision of the manuscript, ET Statistical analysis, GT, SG, DH, DJ, DN, MO, JS, CS, MT, GV Provision of data, critical revision of the manuscript, all authors read and approved the final manuscript.

Abstract

Background

Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health.

Methods

Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively.

Results

Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function.

Conclusion

Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.
Zusatzmaterial
Additional file 1: Detailed information about the selected home characteristics as possible predictors for microbial exposure in mattress dust.
12890_2015_42_MOESM1_ESM.doc
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