nach oben

Journal of Cancer Research and Clinical Oncology

Erschienen in:

12.03.2018 | Original Article – Cancer Research

Predictors of recurrence and survival of pathological T1N0M0 invasive adenocarcinoma following lobectomy

verfasst von: Yiyang Wang, Difan Zheng, Jiajie Zheng, Qingyuan Huang, Baohui Han, Jie Zhang, Heng Zhao, Haiquan Chen

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

This retrospective research was designed to investigate the relationship between pT1N0M0 invasive adenocarcinoma (IADC) harboring solid (SOL) and/or micropapillary (MIP) components and its prognosis following lobectomy.

Methods

Clinical data of pT1N0M0 IADC patients were retrospectively collected from Shanghai Chest Hospital. Survival curves were plotted by Kaplan–Meier methods. Multivariable cox regressions were conducted to discover the independent risk factors of recurrence-free survival (RFS) and overall survival (OS), through which nomograms were performed to visualize the risk of recurrences and outcomes in personalized information.

Results

Totally, 1965 patients were enrolled, including 248 harboring SOL/MIP and 1717 not. IADC demonstrated worse 5-year RFS (81.9 vs. 92.2%, p < 0.001) and OS (85.7 vs. 94.4%, p < 0.001) when harboring SOL and/or MIP components. And this status became an independent factor associated with poorer RFS (HR 2.445, 95% CI 1.565–3.821, p < 0.001) and OS (HR 2.139, 95% CI 1.180–3.878, p = 0.012) instead of novel classification of IADC predominant patterns. No difference existed between SOL/MIP predominant and minor patterns. In addition, age > 60, smoking, post-chemotherapy and T1b were all indicating poorer RFS and smoking was also related with worse OS. The c-indexes of nomograms were 0.723 for RFS (95% CI, 0.662–0.784) and 0.703 for OS (95% CI, 0.629–0.777) respectively.

Conclusions

Once the pT1N0M0 IADC harboring SOL/MIP, it strongly indicated the worse clinical recurrence and survival outcome, no matter whether the SOL and/or MIP was predominant. Smoking was correlated with worse prognosis for those patients. Age > 60 and stage T1b also indicated poorer RFS. Whether post-chemotherapy was harmful to pT1N0M0 IADC patients needed further research.

Nur mit Berechtigung zugänglich

Cao Y, Zhu LZ, Jiang MJ et al (2016) Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review. Onco Targets Ther 9:149–158PubMed

Chen Z, Fillmore CM, Hammerman PS et al (2014) Non small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer 14(8):535–534CrossRefPubMedCentralPubMed

Chen W, Zheng R, Baade PD et al (2016) Cancer statistics in China, 2015. CA Cancer J Clin 66(2):115–32CrossRefPubMed

Dai C, Shen J, Ren Y et al (2016) Choice of surgical procedure for patients with NSCLC ≤ 1 cm or 1 to 2 cm among lobectomy, segmentectomy, and wedge resection: a population-based study. J Clin Oncol 34(26):3175–3182CrossRefPubMed

Duan F, Fagerstrom RM et al (2013) Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med 368(21):1980–1991CrossRefPubMed

Eng L, Su J, Qiu X et al (2014) Second-hand smoke as a predictor of smoking cessation among lung cancer survivors. J Clin Oncol 32(6):564–570CrossRefPubMed

Ginsberg RJ, Rubinstein LV (1995) Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 60:615–622 (discussion 622–613)CrossRefPubMed

Goldstraw P, Crowley J, Chansky K, International Association for the Study of Lung Cancer International Staging Committee, Participating Institutions et al (2007) The IASLC lung cancer staging project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2:706–714CrossRefPubMed

Harrell FE Jr (2001) Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis (Springer series in statistics). Springer, New YorkCrossRef

Hung JJ, Wu YC, Chou TY et al (2016) Adjuvant chemotherapy improves the probability of freedom from recurrence in patients with resected stage IB lung adenocarcinoma. Ann Thorac Surg 101(4):1346–1353CrossRefPubMed

Jared D, Christensen CC (2015) Low-dose computed tomographic screening for lung cancer. Clin Chest Med 36:147–160CrossRef

Little AG, Rusch VW, Bonner JA et al (2005) Patterns of surgical care of lung cancer patients. Ann Thorac Surg 80:2051–2056 (discussion 2056)CrossRefPubMed

Ludwig MS, Goodman M, Miller DL et al (2005) Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer. Chest 128(3):1545–1550CrossRefPubMed

Maurichi A, Miceli R, Camerini T et al (2014) Prediction of survival in patients with thin melanoma: results from a multi-institution study. J Clin Oncol 32(23):2479–2485CrossRefPubMed

Mollberg NM, Bennette C et al (2014) Lymphovascular invasion as a prognostic indicator in stage I non-small cell lung cancer: a systemic review and meta-analysis. Ann Thorac Surg 97(3):965–971CrossRefPubMed

Morales-Oyarvide V, Mino-Kenudson M (2014) High-grade lung adenocarcinomas with micropapillary and/or solid patterns: a review. Curr Opin Pulm Med 20(4):317–323CrossRefPubMed

Naoki Yanagawa S, Shiono M, Abiko et al (2016) The clinical impact of solid and micropapillary patterns in resected lung adenocarcinoma. J Thorac Oncol 11(11):1976–1983CrossRefPubMed

Nitadori J, Bograd AJ, Kadota K et al (2013) Impact of micropapillary histologic subtype in selecting limited resection vs lobectomy for lung adenocarcinoma of 2 cm or smaller. J Natl Cancer Inst 105(16):1212–1220CrossRefPubMedCentralPubMed

Rami-Porta R, Ball D, Crowley J et al (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2:593–602CrossRefPubMed

Russell PA, Wainer Z, Wright GM et al (2011) Does lung adenocarcinoma subtype predict patient survival? A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung adenocarcinoma classification. J Thorac Oncol 6(9):1496–1504CrossRefPubMed

Sica G, Yoshizawa A, Sima CS et al (2010) A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors. Am J Surg Pathol 34(8):1155–1162CrossRefPubMed

Siegel R, Naishadham D, Jemal A (2013) Cancer statistics. CA Cancer J Clin 63:11–30CrossRefPubMed

Travis WD, Garg K, Franklin WA et al (2005) Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol 23:3279–3287CrossRefPubMed

Travis WD, Brambilla E, Noguchi M et al (2011) International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6(2):244–285CrossRefPubMedCentralPubMed

Travis WD, Brambilla E, Nicholson AG et al (2015a) The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol 10:1243–1260CrossRefPubMed

Travis WD, Brambilla E, Nicholson AG et al (2015b) The 2015 World Health Organization Classification of Lung Tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol 10(9):1243–1260CrossRefPubMed

Travis WD, Asamura H, Bankier AA et al (2016) The IASLC lung cancer staging project: proposals for coding T categories for subsolid nodules and assessment of tumor size in part-solid tumors in the forthcoming eighth edition of the TNM classification of lung cancer. J Thorac Oncol 11(8):1204–1223CrossRefPubMed

Tsao MS, Marguet S, Le Teuff G et al (2015) Subtype classification of lung adenocarcinoma predicts benefit from adjuvant chemotherapy in patients undergoing complete resection. J Clin Oncol 33(30):3439–3446CrossRefPubMedCentralPubMed

Waller LL, Weaver KE, Petty WJ et al (2010) Effects of continued tobacco use during treatment of lung cancer. Expert Rev Anticancer Ther 10(10):1569–1575CrossRefPubMed

Yeh YC, Kadota K, Nitadori JI et al (2016) International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification predicts occult lymph node metastasis in clinically mediastinal node-negative lung adenocarcinoma. Eur J Cardiothorac Surg 49(1):e9–e15CrossRefPubMed

Yoshiya T, Mimae T, Tsutani Y et al (2016) Prognostic role of subtype classification in small-sized pathologic N0 invasive lung adenocarcinoma. Ann Thorac Surg 102(5):1668–1673CrossRefPubMed

Zhang J, Wu J, Tan Q et al (2013) Why do pathological stage IA lung adenocarcinomas vary from prognosis? A clinicopathologic study of 176 patients with pathological stage IA lung adenocarcinoma based on the IASLC/ATS/ERS classification. J Thorac Oncol 8(9):1196–1202CrossRefPubMed

Zhang Y, Li J, Wang R et al (2014) The prognostic and predictive value of solid subtype in invasive lung adenocarcinoma. Sci Rep 24(4):7163

Zhao Y, Wang R, Shen X et al (2016) Minor components of micropapillary and solid subtypes in lung adenocarcinoma are predictors of lymph node metastasis and poor prognosis. Ann Surg Oncol 23(6):2099–2105CrossRefPubMedCentralPubMed

Titel: Predictors of recurrence and survival of pathological T1N0M0 invasive adenocarcinoma following lobectomy
verfasst von: Yiyang Wang
Difan Zheng
Jiajie Zheng
Qingyuan Huang
Baohui Han
Jie Zhang
Heng Zhao
Haiquan Chen
Publikationsdatum: 12.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 6/2018
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2622-8

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Predictors of recurrence and survival of pathological T1N0M0 invasive adenocarcinoma following lobectomy

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2018

Role of natural killer cells in lung cancer

Whole-exome sequencing identifies key mutated genes in T790M wildtype/cMET-unamplified lung adenocarcinoma with acquired resistance to first-generation EGFR tyrosine kinase inhibitors

Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival

Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway

Impact of peri-operative blood transfusion on post-operative infections after radical gastrectomy for gastric cancer: a propensity score matching analysis focusing on the timing, amount of transfusion and role of leukocyte depletion

Trabectedin plus pegylated liposomal doxorubicin (PLD) for patients with platinum-sensitive recurrent ovarian cancer: a prospective, observational, multicenter study

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie