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Erschienen in: General Thoracic and Cardiovascular Surgery 3/2024

07.09.2023 | Original Article

Predictors of residual simultaneous multiple ground-glass nodule progression after dominant lesion resection

verfasst von: Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Keiju Aokage, Masahiro Tsuboi

Erschienen in: General Thoracic and Cardiovascular Surgery | Ausgabe 3/2024

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Abstract

Objective

This study aimed to identify the predictive factors for the progression of residual simultaneous multifocal ground-glass nodules (SMGGNs) after resection of the dominant lesion.

Methods

Patients (n = 3420) with primary lung cancer who underwent lung resections at our hospital between 2006 and 2016 were screened, and the data from 82 patients who had residual SMGGNs after undergoing surgery for the dominant lesion (pathologically stage 0-IIA) were retrospectively analyzed. Clinicopathological factors that predicted the growth of residual second dominant GGNs were identified.

Results

Median total tumor and solid component sizes of the residual second dominant GGNs were 1.3 cm (interquartile range [IQR]: 0.6–2.0) and 0 cm (IQR: 0–0.7), respectively. During a median follow-up period of 54 months (IQR: 37–78 months), 35 (43%) lesions progressed. Logistic regression analysis revealed that age younger than 70 (OR: 10.54, 95% CI: 1.71–65.11), a dominant lesion with pure solid appearance (reference: GGN, OR: 18.16, 95% CI: 1.66–198.60), a second dominant GGN total size larger than 1.0 cm (OR: 12.27, 95% CI: 1.85–81.17), and a second dominant GGN solid component size larger than 0.5 cm (OR: 17.59, 95% CI: 3.58–86.47) were significant predictive factors for the progression of residual GGNs (all p values < 0.03). Based on an analysis of growth patterns, rapid growth was higher in second dominant GGNs with a part-solid appearance.

Conclusions

If the resected dominant lesion or the residual second dominant GGN exhibits high-risk factors, the second dominant GGN should be meticulously observed.
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Metadaten
Titel
Predictors of residual simultaneous multiple ground-glass nodule progression after dominant lesion resection
verfasst von
Tomohiro Miyoshi
Kenta Tane
Joji Samejima
Keiju Aokage
Masahiro Tsuboi
Publikationsdatum
07.09.2023
Verlag
Springer Nature Singapore
Erschienen in
General Thoracic and Cardiovascular Surgery / Ausgabe 3/2024
Print ISSN: 1863-6705
Elektronische ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-023-01968-x

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