Preferences Regarding Shared Decision-Making in Japanese Inflammatory Bowel Disease Patients

Several recent studies indicate that patients in the US prefer to be involved in decisions concerning their treatment, and patient participation in these decisions improves compliance with the treatment regimen and the patient’s overall condition [1‐5]. Other studies in Europe have shown similar results [6‐9].

Shared decision-making (SDM) is defined as the process of interaction between patients who wish to be involved in making treatment decisions and their healthcare providers. Usually, the responsibility of informing and recommending treatment to patients lies with their healthcare providers, and it is only the process of deciding how to act on this information that is shared with the patients. With SDM, the goal is to enhance patient involvement, and, on the basis of the available evidence, facilitate “evidence-based patient choice” [10, 11]. SDM can therefore be used to educate patients about the utmost importance of adherence to medication and the necessity to commit and follow through on their treatment [12]. SDM has become even more important in inflammatory bowel disease (IBD) as new medications are developed, new side effects become known, and the risk-versus-benefit ratio becomes more difficult to interpret. IBD, which includes both Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory condition of the intestinal tract. There is no cure for either CD or UC, and these patients face numerous decisions regarding treatment of their disease [13]. Several therapeutic strategies, including the wide use of immunosuppressants, have been advocated in the treatment of CD and UC, each with its own risks and benefits [9, 14].

Given the variety of issues facing IBD patients and their providers, a number of studies have used survey methods to obtain information on a range of issues [14]. However, we have been unable to find any research work on SDM among Japanese IBD patients. Accordingly, it is unknown to what extent Japanese IBD patients actually want to be involved in decision-making regarding the most appropriate therapeutic strategy for their disease. Comprehending the situation of IBD patients’ preferences with regard to their involvement in the decision of treatment choices is of great importance in deciding on an appropriate treatment regimen.

The current study investigated the interest of Japanese IBD patients to have input in the selection of their course of treatment and compared how that interest varied based on patient characteristics.

This is the first large survey to demonstrate that Japanese IBD patients prefer to be involved in the decision-making process regarding their treatment. Japanese patients have traditionally allowed their physician to have absolute authority over their treatment [1]. However, the internet has provided Japanese patients easier access to medical information and medical education. Such internet access has been shown to allow patients to play a greater role in decision-making concerning treatment in other countries [5, 6, 16]. The current study referred to and applied a questionnaire developed for a study in The Netherlands. This study found that the majority of Dutch IBD patients wanted to play an active role in the decisions regarding their treatment [9]. The current study evaluated the importance of SDM to Japanese IBD patients; the results indicate that a majority of these patients felt that it is very important that they share in the determination of their treatment modality. Furthermore, an analysis of the importance of these preferences shows that they are strongly associated with certain disease comorbidities, surgical history, and the patients’ current treatment, along with their disease state.

A previous study among eight Asian countries excluding Japan suggested that surgical history is associated with severe UC disease stage, although this is not the case in CD where disease progression is non-linear [17]. However, the association between surgical history and the preference regarding SDM in the total study population for this current study might be driven by the UC patients’ preference, since a significant proportion of the patients sampled in this study had UC (77%). The results of the sensitivity analysis support this hypothesis (data not shown).

In addition, many patients from this survey have other comorbidities such as dyslipidemia and COPD/asthma. Keely et al. reported pulmonary intestinal cross-talk between mucosal inflammatory diseases and IBD. They discussed the possibility of common risk factors, such as smoking and genetics, as well as epithelial barrier dysfunction and inflammation, as common characteristics of both conditions [18].

Further, Koutroumpakis et al. reported an association between long-term lipid profiles and IBD disease severity [19]. Dyslipidemia is a well-established risk factor for cardiovascular disease; however, their large cohort study suggested IBD patients had less frequent incidence of high total cholesterol and high LDL cholesterol and more frequent incidence of low HDL and high triglycerides in comparison to the general population. This is consistent with the current survey results and the association with disease severity.

Multimorbidity is associated with a significantly worse quality of life in the general population. The current survey results find that patients with dyslipidemia or COPD/asthma with moderate IBD favor SDM. Furthermore, there is a strong association between the importance of SDM and patients treated at university hospitals. Since physicians at university hospitals tend to be the leading experts in their field, the increased importance of SDM among patients being treated at university hospitals might be related to greater severity of the disease in such patients as well as for the stronger need to control comorbidities. The current survey results also show a difference between CD and UC patients regarding SDM. There are fewer factors associated with SDM in CD patients than in UC patients. The majority of CD patients have a surgical history and a lengthy time since diagnosis, have used or are currently using biologics agents, and are being treated at university hospitals, suggesting that they might spend more time communicating with their physician about the treatment compared to UC patients.

The use of biologic agents to treat IBD is also associated with the severity of the disease state [20]. Another finding is the proportion of patients in current treatment with relatively severe disease. This survey’s results suggest that the majority of CD patients have severe disease. Furthermore, a review of current treatment approaches of patients in this study provides insights into the severity of the disease and suggests that patients with more severe disease in this study might be the majority in CD patients, which, in turn, might be a factor in the difference between CD and UC patients regarding SDM.

These findings are not consistent with those from some previous studies. A recent study of young patients from Japan and the US found that both populations favored patient-centered care for less serious disease conditions [1]. Additional research suggests that Japanese patients prefer not to be involved in decision-making if it involves a life-threatening condition, such as cancer [21, 22].

Married patients also show a strong preference for SDM in comparison to unmarried patients. This is not consistent with a study by Dronkers et al. that found unmarried head-and-neck cancer patients also favored an active role in their treatment [23]. However, Forsythe et al. found married long-term cancer patients were more likely to want to participate in the decision-making regarding treatment [24]. These differences might be associated with the role of family support or participation in the decision-making process. Thus, for married IBD patients, the spouse and family members might play an important role in the decision-making process in regard to treatment.

The results from current study of Japanese patients with IBD indicate that the majority of patients want to have an active role in their treatment plan. There is no association between the patients’ preference for SDM and their age, gender, education level, or socioeconomic status. Instead, the importance of SDM appears to be associated with their marital status, treatment at university hospitals, their general health condition, and comorbidities. In addition, patients with a surgical history and those treated with biologic agents also favor SDM.

Based on the findings of the Baars et al. study, patients in The Netherlands appear to play a more aggressive role in the decision-making than that played by Japanese patients in the current study [9]. This might be due to differences in the physicians’ availability for consultation in the two countries, as consultation time with Japanese physicians tends to be quite limited.

The difference might also be due to the broader availability of biologic agents in The Netherlands. The first biologic agent was approved for use for CD in Japan in the early 2000s and after 2010 for UC, and for several years, use of biologics was confined to a limited number of leading hospitals. The current study shows that Japanese patients treated at university hospitals want to be more involved in their treatment decisions in comparison to patients who visited clinics or general hospitals. As well as the possible impact of disease severity, current treatment regimens that include biologics might be an underlying factor in this regard.

Results from the present study found that the majority of IBD patients in Japan want a role in their treatment plan. The results also indicate that the patient’s preference in regard to SDM is driven by their perception of the severity or progression of their disease. The results of our study also showed that preferences in regard to SDM in Japanese IBD patients were similar to Dutch IBD patients.