Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain, and fibromyalgia. A qualitative study was undertaken in Jordan, where concerns have been raised about its unprescribed availability in community pharmacies and thereby its abuse. Semi-structured interviews were conducted with all patients with a history of pregabalin use in two Jordanian addiction treatment centers. All were male patients aged 21–30 years (n = 11). The majority was poly-drug abusers and had a previous history of substance abuse (tramadol, Captagon, synthetic cannabinoids, and marijuana). Six key themes emerged from a content textual analysis which centered on pregabalin and other drugs; the pregabalin effect; poly-pharming and pregabalin intoxication; trajectories, patterns, and routes of administration; dependence and withdrawal; and sourcing of pregabalin. The study underscores the need for continued pharmacovigilance to manage and address suspected abuse, along with community pharmacist and patient education regarding abuse liability and related harms.
Albsoul-Younes, A., Wazaify, M., Yousef, A. M., & Tahaineh, L. (2010). Abuse and misuse of prescription and nonprescription drugs sold in community pharmacies in Jordan. Substance Use & Misuse, 45(9), 1319–1329. CrossRef
Babbie, E. R. (2010). The practice of social research (12th ed.p. 530). Wadsworth: Cengage Learning.
Drug Enforcement Administration, Department of Justice. (2005). Schedules of controlled substances: placement of pregabalin into schedule V. Final rule. Federal Register, 70(144), 43633.
Dum, J., Gramsch, C. H., & Herz, A. (1983). Activation of hypothalamic β-endorphin pools by reward induced by highly palatable food. Pharmacology Biochemistry and Behavior, 18(3), 443–447. CrossRef
Freynhagen, R., Backonja, M., Schug, S., Lyndon, G., Parsons, B., Watt, S., & Behar, R. (2016). Pregabalin for the treatment of drug and alcohol withdrawal symptoms: a comprehensive review. CNS Drugs, 30, 1–10. CrossRef
Grosshans, M., Lemenager, T., Vollmert, C., Kaemmerer, N., Schreiner, R., Mutschler, J., ... & Hermann, D. (2013). Pregabalin abuse among opiate addicted patients. European Journal of Clinical Pharmacology, 69(12), 2021–2025.
Hernandez, S. H., & Nelson, L. S. (2010). Prescription drug abuse: insight into the epidemic. Clinical Pharmacology & Therapeutics, 88(3), 307–317. CrossRef
Holsti, O. R. (1969). Content analysis for the social sciences and humanities. Reading: Addison-Wesley.
Hughes, G. F., McElnay, J. C., Hughes, C. M., & McKenna, P. (1999). Abuse/misuse of non-prescription drugs. Pharmacy World & Science, 21(6), 251–255. CrossRef
Husserl, E. (1970). Logical investigation. New York: Humanities Press.
Jaber, D., Bulatova, N., Suyagh, M., Yousef, A. M., & Wazaify, M. (2015). Knowledge, attitude and opinion of drug misuse and abuse by pharmacy students: a cross-sectional study in Jordan. Tropical Journal of Pharmaceutical Research, 14(8), 1501–1508. CrossRef
Jordan Food and drug Administration (JFDA). (2014). Formal statement about the restricted dispensing of pregabalin in Jordan. Can be obtained from URL: http://www.jfda.jo/EchoBusV3.0/SystemAssets/ce7e7f71-3158-4f56-92bd 5ea766cbce16.jpg. Accessed June 11th 2016.
Jordan Food and drug Administration (JFDA). (2017). Formal statement about the restricted dispensing of pregabalin in Jordan. Can be obtained from URL: http://www.jfda.jo/EchoBusV3.0/SystemAssets/2f00f42e-427b-40ba-abf4 93adfb8c2ad6.jpg. Accessed May 10th 2017.
Millar, J., Sadasivan, S., Weatherup, N., & Lutton, S. (2013). Lyrica nights—recreational pregabalin abuse in an urban emergency department. Emergency Medicine Journal, 30(10), 874–874. CrossRef
National Institute on Drug Abuse (NIDA). (2014). Commonly abused drugs charts. Retrieved from. https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs charts. Accessed May 10th 2017.
Schifano, F., D’Offizi, S., Piccione, M., Corazza, O., Deluca, P., Davey, Z., ... & Mannonen, M. (2011). Is there a recreational misuse potential for pregabalin? Analysis of anecdotal online reports in comparison with related gabapentin and clonazepam data. Psychotherapy and Psychosomatics, 80(2), 118–122.
Van Hout, M. C., & Hearne, E. (2017). User experiences of development of dependence on the synthetic cannabinoids, 5f-AKB48 and 5F-PB-22, and subsequent withdrawal syndromes. International Journal of Mental Health and Addiction, 15(3), 565–579. CrossRef
Wazaify, M., Abood, E., Tahaineh, L., & Albsoul-Younes, A. (2016). Jordanian community pharmacists’ experience regarding prescription and nonprescription drug abuse and misuse in Jordan—an update. Journal of Substance Use, 1–6.
Yazdi, K., Hemetsberger, U., & Baier, C. (2015). Pregabalin abuse of bebzodiazepine and alcohol addicted patient. Psychiatria Danubina, 27(3), 279.
- Pregabalin Misuse and Abuse in Jordan: a Qualitative Study of User Experiences
Marie Claire Van Hout
- Springer US
International Journal of Mental Health and Addiction
Print ISSN: 1557-1874
Elektronische ISSN: 1557-1882