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11.10.2016 | Original Article | Ausgabe 3/2017

Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease

Zeitschrift:: Irish Journal of Medical Science (1971 -) > Ausgabe 3/2017

Autoren:: H. Gutiérrez-Leonard, E. Martínez-Lara, A. E. Fierro-Macías, V. M. Mena-Burciaga, M. D. Ronquillo-Sánchez, E. Floriano-Sánchez, N. Cárdenas-Rodríguez

Abstract

Background

Cardiovascular disease is the leading cause of death in the Western world, and a major cause of this disease is atherosclerosis. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage.

Aim

The aim of this work was to investigate the correlation between PAPP-A concentrations in coronary and peripheral blood and certain clinicopathological factors and antioxidant enzyme activities in patients diagnosed with coronary artery disease.

Methods

For 65 patients, arterial blood was obtained by puncturing the femoral or radial artery, and coronary blood was obtained via percutaneous coronary intervention. PAPP-A, catalase (CAT), superoxide dismutase-1 (SOD-1), and superoxide dismutase-2 (SOD-2) levels were measured using spectrometric methods.

Results

Coronary PAPP-A levels were slightly higher than peripheral PAPP-A levels (81.25 ± 2.34 and 62 ± 3 ng/mL, respectively, P < 0.0001); these levels were correlated with each other (r = 0.6629, P < 0.001) but not with clinicopathological factors (P > 0.05). Coronary PAPP-A levels were significantly elevated among patients at risk for cardiovascular disease (P < 0.05). Antioxidant enzyme activities were significantly higher in coronary samples than in peripheral samples from subjects with ischemic cardiopathy secondary to atherosclerosis (P < 0.001). Neither coronary nor peripheral PAPP-A levels were correlated with antioxidant enzyme activities in patients with cardiopathy secondary to atherosclerosis (P > 0.05).

Conclusions

PAPP-A levels could be used as biomarkers to identify patients at risk of coronary artery disease.

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Titel: Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease
Autoren:: H. Gutiérrez-Leonard
E. Martínez-Lara
A. E. Fierro-Macías
V. M. Mena-Burciaga
M. D. Ronquillo-Sánchez
E. Floriano-Sánchez
N. Cárdenas-Rodríguez
Publikationsdatum: 11.10.2016
DOI: https://doi.org/10.1007/s11845-016-1515-6
Verlag: Springer London
Zeitschrift: Irish Journal of Medical Science (1971 -)
Ausgabe 3/2017
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362

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Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease

Abstract

Background

Aim

Methods

Results

Conclusions

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Abstract

Background

Aim

Methods

Results

Conclusions

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