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11.10.2016 | Original Article | Ausgabe 3/2017

Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease

Zeitschrift:: Irish Journal of Medical Science (1971 -) > Ausgabe 3/2017

Autoren:: H. Gutiérrez-Leonard, E. Martínez-Lara, A. E. Fierro-Macías, V. M. Mena-Burciaga, M. D. Ronquillo-Sánchez, E. Floriano-Sánchez, N. Cárdenas-Rodríguez

Abstract

Background

Cardiovascular disease is the leading cause of death in the Western world, and a major cause of this disease is atherosclerosis. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage.

Aim

The aim of this work was to investigate the correlation between PAPP-A concentrations in coronary and peripheral blood and certain clinicopathological factors and antioxidant enzyme activities in patients diagnosed with coronary artery disease.

Methods

For 65 patients, arterial blood was obtained by puncturing the femoral or radial artery, and coronary blood was obtained via percutaneous coronary intervention. PAPP-A, catalase (CAT), superoxide dismutase-1 (SOD-1), and superoxide dismutase-2 (SOD-2) levels were measured using spectrometric methods.

Results

Coronary PAPP-A levels were slightly higher than peripheral PAPP-A levels (81.25 ± 2.34 and 62 ± 3 ng/mL, respectively, P < 0.0001); these levels were correlated with each other (r = 0.6629, P < 0.001) but not with clinicopathological factors (P > 0.05). Coronary PAPP-A levels were significantly elevated among patients at risk for cardiovascular disease (P < 0.05). Antioxidant enzyme activities were significantly higher in coronary samples than in peripheral samples from subjects with ischemic cardiopathy secondary to atherosclerosis (P < 0.001). Neither coronary nor peripheral PAPP-A levels were correlated with antioxidant enzyme activities in patients with cardiopathy secondary to atherosclerosis (P > 0.05).

Conclusions

PAPP-A levels could be used as biomarkers to identify patients at risk of coronary artery disease.

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Clark LT (1986) Cholesterol and heart disease: current concepts in pathogenesis and treatment. J Natl Med Assoc 78:743–745 PubMedPubMedCentral

Tsutsumi A (2015) Prevention and management of work-related cardiovascular disorders. Int J Occup Med Environ Health 28:4–7. doi: 10.2478/s13382-014-0319-z PubMed

Thom T, Haase N, Rosamond W (2006) Heart disease and stroke statistics—2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113:e85–e151. doi: 10.1161/CIRCULATIONAHA.105.171600 CrossRefPubMed

Rugg SS, Bailey AL, Browning SR (2008) Preventing cardiovascular disease in Kentucky: epidemiology, trends, and strategies for the future. J Ky Med Assoc 106:149–161 PubMed

Libby P (2002) Inflammation in atherosclerosis. Nature 420:868–874. doi: 10.1038/nature01323 CrossRef

Delafontaine P (1995) Insulin-like growth factor I and its binding proteins in the cardiovascular system. Cardiovasc Res 30:825–834 CrossRefPubMed

Bayes-Genis A, Conover CA, Schwartz RS (2000) The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ Res 86:125–130. doi: 10.1161/01.RES.86.2.125 CrossRefPubMed

Bach LA (2004) The insulin-like growth factor system: towards clinical applications. Clin Biochem Rev 25:155–164 PubMedPubMedCentral

Mahmoudabady M, Mathieu M, Touihri K et al (2009) Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy. BMC Cardiovasc Disord 9:49. doi: 10.1186/1471-2261-9-49 CrossRefPubMedPubMedCentral

10.

Lin T, Halbert SP, Kiefer D et al (1974) Characterization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol 118:223–236. doi: 10.1016/0002-9378(74)90553-5 CrossRefPubMed

11.

Lawrence JB, Oxvig C, Overgaard MT et al (1999) The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci USA 96:3149–3153. doi: 10.1073/pnas.96.6.3149 CrossRefPubMedPubMedCentral

12.

Boldt HB, Conover CA (2007) Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm IGF Res 17:10–18. doi: 10.1016/j.ghir.2006.11.003 CrossRefPubMed

13.

Bayes-Genis A, Conover CA, Overgaard MT et al (2001) Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 345:1022–1029. doi: 10.1056/NEJMoa003147 CrossRefPubMed

14.

Lund J, Qin QP, Ilva T et al (2003) Circulating pregnancy-associated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation 108:1924–1926. doi: 10.1161/01.CIR.0000096054.18485.07 CrossRefPubMed

15.

Heeschen C, Dimmeler S, Hamm CW et al (2005) Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol 45:229–237. doi: 10.1016/j.jacc.2004.09.060 CrossRefPubMed

16.

Khosravi J, Diamandi A, Krishna RG et al (2002) Pregnancy associated plasma protein-A: ultrasensitive immunoassay and determination in coronary heart disease. Clin Biochem 35:531–538. doi: 10.1016/S0009-9120(02)00359-4 CrossRefPubMed

17.

Laterza OF, Cameron SJ, Chappell D et al (2004) Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients. Clin Chim Acta 348:163–169. doi: 10.1016/j.cccn.2004.05.022 CrossRefPubMed

18.

Conti E, Volpe M, Carrozza C et al (2005) Pregnancy-associated plasma protein-A and acute coronary syndromes: cause or consequence? J Am Coll Cardiol 46:1583–1584. doi: 10.1016/j.jacc.2005.07.033 CrossRefPubMed

19.

Li XP, Zhou SH, Tang JZ et al (2007) Changes of plasma CD40L and PAPP-A in patients with acute coronary syndrome after the PCI operation. Zhong Nan da Xue Xue Bao Yi Xue Ban 32:1098–1101 PubMed

20.

Elesber AA, Lerman A, Denktas AE et al (2007) Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department. Int J Cardiol 117:365–369. doi: 10.1016/j.ijcard.2006.05.021 CrossRefPubMed

21.

Miedema MD, Conover CA, MacDonald H et al (2008) Pregnancy-associated plasma protein-A elevation in patients with acute coronary syndrome and subsequent atorvastatin therapy. Am J Cardiol 101:35–39. doi: 10.1016/j.amjcard.2007.07.045 CrossRefPubMed

22.

Liu ZY, Zhang JY, Sun TW et al (2008) Levels of pregnancy-associated plasma protein A in patients with coronary artery disease. Clin Invest Med 31:E85–E89 CrossRefPubMed

23.

Hájek P, Macek M, Hladíková M et al (2008) Pregnancy-associated plasma protein A and proform eosinophilic major basic protein in the detection of different types of coronary artery disease. Physiol Res 57:23–32 PubMed

24.

Iversen KK, Dalsgaard M, Teisner AS et al (2009) Usefulness of pregnancy-associated plasma protein A in patients with acute coronary syndrome. Am J Cardiol 104:1465–1471. doi: 10.1016/j.amjcard.2009.07.017 CrossRefPubMed

25.

Iversen KK, Teisner AS, Teisner B et al (2009) Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome. Clin Biochem 42:828–834. doi: 10.1016/j.clinbiochem.2009.01.011 CrossRefPubMed

26.

Schoos M, Iversen K, Teisner A et al (2009) Release patterns of pregnancy-associated plasma protein A in patients with acute coronary syndromes assessed by an optimized monoclonal antibody assay. Scand J Clin Lab Invest 69:121–127. doi: 10.1080/00365510802439080 CrossRefPubMed

27.

Lund J, Wittfooth S, Qin QP et al (2010) Free vs total pregnancy-associated plasma protein A (PAPP-A) as a predictor of 1-year outcome in patients presenting with non-ST-elevation acute coronary syndrome. Clin Chem 56:1158–1165. doi: 10.1373/clinchem.2009.136960 CrossRefPubMed

28.

Liu P, Yan J, Gong J et al (2011) Positive correlation between pregnancy-associated plasma protein-A level and OX40 ligand expression in patients with acute coronary syndromes. Biomed Pharmacother 65:193–197. doi: 10.1016/j.biopha.2010.10.011 CrossRefPubMed

29.

Mei WY, Du ZM, Zhao Q et al (2011) Pregnancy-associated plasma protein predicts outcomes of percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome. Heart Lung 40:e78–e83. doi: 10.1016/j.hrtlng.2010.06.006 CrossRefPubMed

30.

Lodh M, Goswami B, Parida A et al (2012) Assessment of serum leptin, pregnancy-associated plasma protein A and CRP levels as indicators of plaque vulnerability in patients with acute coronary syndrome. Cardiovasc J Afr 23:330–335. doi: 10.5830/CVJA-2012-008 CrossRefPubMedPubMedCentral

31.

Hájek P, Macek M, Pešková M et al (2012) High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naïve patients. J Thromb Thrombolysis 34:99–105. doi: 10.1007/s11239-012-0679-9 CrossRefPubMed

32.

Von Haehling S, Doehner W, Jankowska EA et al (2013) Value of serum pregnancy-associated plasma protein A for predicting cardiovascular events among patients presenting with cardiac chest pain. CMAJ 185:E295–E303. doi: 10.1503/cmaj.110647 CrossRef

33.

Iversen KK, Dalsgaard M, Teisner AS et al (2010) Pregnancy-associated plasma protein-A, a marker for outcome in patients suspected for acute coronary syndrome. Clin Biochem 43:851–857. doi: 10.1016/j.clinbiochem.2010.03.018 CrossRefPubMed

34.

Fong SW, Few LL, See Too WC et al (2015) Systemic and coronary levels of CRP, MPO, sCD40L and PlGF in patients with coronary artery disease. BMC Res Notes 8:679. doi: 10.1186/s13104-015-1677-8 CrossRefPubMedPubMedCentral

35.

Leite WF, Ramires JA, Moreira LF et al (2015) Correlation between C-reactive protein in peripheral vein and coronary sinus in stable and unstable angina. Arq Bras Cardiol 104:202–208. doi: 10.5935/abc.20140188 PubMedPubMedCentral

36.

Wang G, Zhang A, Han X et al (2013) Effect of routine heparins treatment in acute coronary syndrome on serum pregnancy-associated plasma protein a concentration. Ann Clin Lab Sci 43:274–277 PubMed

37.

Hjortebjerg R, Lindberg S, Hoffmann S et al (2015) PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI. Clin Biochem 48:322–328. doi: 10.1016/j.clinbiochem.2014.11.022 CrossRefPubMed

38.

Zengin E, Sinning C, Zeller T et al (2015) The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease. Biomark Med 9:731–741. doi: 10.2217/BMM.15.41 CrossRefPubMed

39.

Wu XF, Yang M, Qu AJ et al (2016) Level of pregnancy-associated plasma protein-A correlates with coronary thin-cap Fibroatheroma burden in patients with coronary artery disease: novel findings from 3-vessel virtual histology intravascular ultrasound assessment. Medicine (Baltimore) 95:e2563. doi: 10.1097/MD.0000000000002563 CrossRef

40.

Cosin-Sales J, Christiansen M, Kaminski P et al (2004) Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris. Circulation 109:1724–1728. doi: 10.1161/01.CIR.0000124716.67921.D2 CrossRefPubMed

41.

Mueller T, Dieplinger B, Poelz W et al (2006) Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study. Clin Chem 52:1096–1103. doi: 10.1373/clinchem.2005.065763 CrossRefPubMed

42.

Cosin-Sales J, Kaski JC, Christiansen M et al (2005) Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris. Eur Heart J 26:2093–2098. doi: 10.1093/eurheartj/ehi433 CrossRefPubMed

43.

Elesber AA, Conover CA, Denktas AE et al (2006) Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. Eur Heart J 27:1678–1684. doi: 10.1093/eurheartj/ehl042 CrossRefPubMed

44.

Stulc T, Malbohan I, Malík J et al (2003) Increased levels of pregnancy-associated plasma protein-A in patients with hypercholesterolemia: the effect of atorvastatin treatment. Am Heart J 146:E21. doi: 10.1016/S0002-8703(03)00446-0 CrossRefPubMed

45.

Aso Y, Okumura K, Wakabayashi S et al (2004) Elevated pregnancy-associated plasma protein-A in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index. J Clin Endocrinol Metab 89:5713–5717. doi: 10.1210/jc.2004-0787 CrossRefPubMed

46.

Bonaca MP, Scirica BM, Sabatine MS et al (2012) Prospective evaluation of pregnancy-associated plasma protein-a and outcomes in patients with acute coronary syndromes. J Am Coll Cardiol 60:332–338. doi: 10.1016/j.jacc.2012.04.023 CrossRefPubMed

47.

Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 285:2486–2497 CrossRef

48.

Heider P, Pfäffle N, Pelisek J et al (2010) Is serum pregnancy-associated plasma protein A really a potential marker of atherosclerotic carotid plaque stability? Eur J Vasc Endovasc Surg 39:668–675. doi: 10.1016/j.ejvs.2010.03.012 CrossRefPubMed

49.

Antoniades C, Tousoulis D, Tentolouris C et al (2003) Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice. Herz 28:628–638. doi: 10.1007/s00059-003-2417-8 CrossRefPubMed

50.

Stocker R, Keaney JF Jr (2004) Role of oxidative modifications in atherosclerosis. Physiol Rev 84:1381–1478. doi: 10.1152/physrev.00047.2003 CrossRefPubMed

51.

Sheu MJ, Hsieh YY, Lai CH et al (2013) Antihyperlipidemic and antioxidant effects of C-phycocyanin in golden Syrian hamsters fed with a hypercholesterolemic diet. J Tradit Compl Med 3:41–47. doi: 10.4103/2225-4110.106545 CrossRef

52.

Gupta S, Sodhi S, Mahajan V (2009) Correlation of antioxidants with lipid peroxidation and lipid profile in patients suffering from coronary artery disease. Expert Opin Ther Targets 13:889–894. doi: 10.1517/14728220903099668 CrossRefPubMed

53.

Li H, Horke S, Förstermann U (2014) Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 237:208–219. doi: 10.1016/j.atherosclerosis.2014.09.001 CrossRefPubMed

54.

Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia-Gonzalez M et al (2005) Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction. Clin Biochem 38:180–182. doi: 10.1016/j.clinbiochem.2004.10.015 CrossRefPubMed

55.

The Joint European Society of Cardiology/Am College of Cardiology Committee (2001) Myocardial infarction redefined—a consensus document of the Joint European Society of Cardiology/Am College of Cardiology committee for the redefinition of myocardial infarction (Special report). Clin Chem 47:382–392

56.

Apple FS, Wu AH, Mair J et al (2005) Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem 51:810–824. doi: 10.1373/clinchem.2004.046292 CrossRefPubMed

57.

Lubrano V, Balzan S (2015) Consolidated and emerging inflammatory markers in coronary artery disease. World J Exp Med 5:21–32. doi: 10.5493/wjem.v5.i1.21 CrossRefPubMedPubMedCentral

Titel: Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease
Autoren:: H. Gutiérrez-Leonard
E. Martínez-Lara
A. E. Fierro-Macías
V. M. Mena-Burciaga
M. D. Ronquillo-Sánchez
E. Floriano-Sánchez
N. Cárdenas-Rodríguez
Publikationsdatum: 11.10.2016
DOI: https://doi.org/10.1007/s11845-016-1515-6
Verlag: Springer London
Zeitschrift: Irish Journal of Medical Science (1971 -)
Ausgabe 3/2017
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362

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Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease

Abstract

Background

Aim

Methods

Results

Conclusions

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Abstract

Background

Aim

Methods

Results

Conclusions

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