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Internal and Emergency Medicine
Erschienen in:

02.05.2023 | IM - ORIGINAL

Prehospital stratification and prioritisation of non-ST-segment elevation acute coronary syndrome patients (NSTEACS): the MARIACHI scale

verfasst von: Silvia Solà-Muñoz, Morales Jorge, Xavier Jiménez-Fàbrega, Sonia Jiménez-Delgado, Youcef Azeli, J. Ramon Marsal, Sara Jordán, Josepa Mauri, Javier Jacob

Erschienen in: Internal and Emergency Medicine | Ausgabe 5/2023

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Abstract

Objective

The objective of this study was to develop and validate a risk scale (MARIACHI) for patients classified as non-ST-segment elevation acute coronary syndrome (NSTEACS) in a prehospital setting with the ability to identify patients at an increased risk of mortality at an early stage.

Methods

A retrospective observational study conducted in Catalonia over two periods: 2015–2017 (development and internal validation cohort) and Aug 2018–Jan 2019 (external validation cohort). We included patients classified as prehospital NSTEACS, assisted by an advanced life support unit and requiring hospital admission. The primary outcome was in-hospital mortality. Cohorts were compared using logistic regression and a predictive model was created using bootstrapping techniques.

Results

The development and internal validation cohort included 519 patients. The model is composed of five variables associated with hospital mortality: age, systolic blood pressure, heart rate > 95 bpm, Killip-Kimball III–IV and ST depression ≥ 0.5 mm. The model showed good overall performance (Brier = 0.043) and consistency in discrimination (AUC 0.88, 95% CI 0.83–0.92) and calibration (slope = 0.91; 95% CI 0.89–0.93). We included 1316 patients for the external validation sample. There was no difference in discrimination (AUC 0.83, 95% CI 0.78–0.87; DeLong Test p = 0.071), but there was in calibration (p < 0.001), so it was recalibrated. The finally model obtained was stratified and scored into three groups according to the predicted risk of patient in-hospital mortality: low risk: < 1% (-8 to 0 points), moderate risk: 1–5% (+ 1 to + 5 points) and high risk: > 5% (6–12 points).

Conclusion

The MARIACHI scale showed correct discrimination and calibration to predict high-risk NSTEACS. Identification of high-risk patients may help with treatment and low referral decisions at the prehospital level.
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Metadaten
Titel
Prehospital stratification and prioritisation of non-ST-segment elevation acute coronary syndrome patients (NSTEACS): the MARIACHI scale
verfasst von
Silvia Solà-Muñoz
Morales Jorge
Xavier Jiménez-Fàbrega
Sonia Jiménez-Delgado
Youcef Azeli
J. Ramon Marsal
Sara Jordán
Josepa Mauri
Javier Jacob
Publikationsdatum
02.05.2023
Verlag
Springer International Publishing
Erschienen in
Internal and Emergency Medicine / Ausgabe 5/2023
Print ISSN: 1828-0447
Elektronische ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-023-03274-z

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