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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.07.2011 | Gonadal Physiology and Disease

Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown

verfasst von: Agnieszka Lechowska, Szczepan Bilinski, Youngsok Choi, Yonghyun Shin, Malgorzata Kloc, Aleksandar Rajkovic

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2011

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Abstract

Purpose

To understand the mechanism of premature ovarian failure (POF).

Methods

The ultrastructural (electron microscopy) analysis of primordial ovarian follicles in Nobox deficient mice.

Results

We studied, for the first time, the fate of oogonia in embryonic (prenatal) mouse ovaries and showed that the abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles.

Conclusions

These results indicate that POF syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development. In addition, the extremely unusual and abnormal presence of adherens junctions between unseparated oocytes within syncytial follicles indicates that faulty communication between somatic and germ cells is involved in, or leads to, abnormalities in the cell adhesion program.

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Titel: Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown
verfasst von: Agnieszka Lechowska
Szczepan Bilinski
Youngsok Choi
Yonghyun Shin
Malgorzata Kloc
Aleksandar Rajkovic
Publikationsdatum: 01.07.2011
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 7/2011
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9553-5

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Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown

Abstract

Purpose

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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