nach oben

Pediatric Surgery International

Erschienen in:

30.04.2018 | Review Article

Prenatal intervention for the management of congenital diaphragmatic hernia

verfasst von: Mariatu A. Verla, Candace C. Style, Oluyinka O. Olutoye

Erschienen in: Pediatric Surgery International | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

Congenital diaphragmatic hernia (CDH) is the result of incomplete formation of the diaphragm that occurs during embryogenesis. The defect in the diaphragm permits the herniation of abdominal organs into the thoracic cavity contributing to the impairment of normal growth and development of the fetal lung. In addition to the hypoplastic lung, anomalies of the pulmonary arterioles worsen the pulmonary hypertension that can have detrimental effects in severe cases. Most cases of CDH can be effectively managed postnatally. Advances in neonatal and surgical care have resulted in improved outcomes over the years. When available, extracorporeal membrane oxygenation can provide temporary cardiorespiratory support for those not effectively supported by mechanical ventilation. In spite of these advances, very severe cases of CDH still carry a very high mortality and morbidity rate. Advances in imaging and evaluation now allow for early and accurate prenatal diagnosis of CDH, thereby identifying those at greatest risk who may benefit from prenatal intervention. This review article discusses some of the surgical and non-surgical prenatal interventions in the management of isolated severe congenital diaphragmatic hernia.

Butler N, Claireaux AE (1962) Congenital diaphragmatic hernia as a cause of perinatal mortality. Lancet 1(7231):659–663CrossRefPubMed

Harrison MR et al (1994) A prospective study of the outcome for fetuses with diaphragmatic hernia. Jama 271(5):382–384CrossRefPubMed

Mah VK et al (2009) Absolute vs relative improvements in congenital diaphragmatic hernia survival: what happened to “hidden mortality”. J Pediatr Surg 44(5):877–882CrossRefPubMed

Allan DW, Greer JJ (1997) Pathogenesis of nitrofen-induced congenital diaphragmatic hernia in fetal rats. J Appl Physiol 83(2):338–347CrossRefPubMed

Adzick NS et al (1985) Correction of congenital diaphragmatic hernia in utero. IV. An early gestational fetal lamb model for pulmonary vascular morphometric analysis. J Pediatr Surg 20(6):673–680CrossRefPubMed

Harrison MR et al (1980) Correction of congenital diaphragmatic hernia in utero. II. Simulated correction permits fetal lung growth with survival at birth. Surgery 88(2):260–268PubMed

Harrison MR, Jester JA, Ross NA (1980) Correction of congenital diaphragmatic hernia in utero. I. The model: intrathoracic balloon produces fatal pulmonary hypoplasia. Surgery 88(1):174–182PubMed

Harrison MR et al (1990) Correction of congenital diaphragmatic hernia in utero, V. Initial clinical experience. J Pediatr Surg 25(1):47–55 (discussion 56–7)CrossRefPubMed

Harrison MR, Ross NA, de Lorimier AA (1981) Correction of congenital diaphragmatic hernia in utero. III. Development of a successful surgical technique using abdominoplasty to avoid compromise of umbilical blood flow. J Pediatr Surg 16(6):934–942CrossRefPubMed

10.

Haricharan RN et al (2009) Identifying neonates at a very high risk for mortality among children with congenital diaphragmatic hernia managed with extracorporeal membrane oxygenation. J Pediatr Surg 44(1):87–93CrossRefPubMed

11.

Kays DW et al (2014) Extracorporeal life support in patients with congenital diaphragmatic hernia: how long should we treat? J Am Coll Surg 218(4):808–817CrossRefPubMedPubMedCentral

12.

Seetharamaiah R et al (2009) Factors associated with survival in infants with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation: a report from the Congenital Diaphragmatic Hernia Study Group. J Pediatr Surg 44(7):1315–1321CrossRefPubMed

13.

Deprest J et al (2006) Current consequences of prenatal diagnosis of congenital diaphragmatic hernia. J Pediatr Surg 41(2):423–430CrossRefPubMed

14.

Fauza DO, Wilson JM (1994) Congenital diaphragmatic hernia and associated anomalies: their incidence, identification, and impact on prognosis. J Pediatr Surg 29(8):1113–1117CrossRefPubMed

15.

Akinkuotu AC et al (2016) An evaluation of the role of concomitant anomalies on the outcomes of fetuses with congenital diaphragmatic hernia. J Pediatr Surg 51(5):714–717CrossRefPubMed

16.

Beals DA et al (1992) Pulmonary growth and remodeling in infants with high-risk congenital diaphragmatic hernia. J Pediatr Surg 27(8):997–1001 (discussion 1001–2)CrossRefPubMed

17.

Mesas Burgos C et al (2016) Differences in outcomes in prenatally diagnosed congenital diaphragmatic hernia compared to postnatal detection: a single-center experience. Fetal Diagn Ther 39(4):241–247CrossRefPubMed

18.

Mehollin-Ray AR et al (2012) Fetal MR imaging of congenital diaphragmatic hernia. Radiographics 32(4):1067–1084CrossRefPubMed

19.

Jani J et al (2007) Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia. Ultrasound Obstet Gynecol 30(1):67–71CrossRefPubMed

20.

Akinkuotu AC et al (2016) Risk-stratification of severity for infants with CDH: prenatal versus postnatal predictors of outcome. J Pediatr Surg 51(1):44–48CrossRefPubMed

21.

Zamora IJ et al (2014) Prenatal MRI fetal lung volumes and percent liver herniation predict pulmonary morbidity in congenital diaphragmatic hernia (CDH). J Pediatr Surg 49(5):688–693CrossRefPubMed

22.

Haller JA Jr et al (1976) Pulmonary and ductal hemodynamics in studies of simulated diaphragmatic hernia of fetal and newborn lambs. J Pediatr Surg 11(5):675–680CrossRefPubMed

23.

Starrett RW, de Lorimier AA (1975) Congenital diaphragmatic hernia in lambs: hemodynamic and ventilatory changes with breathing. J Pediatr Surg 10(5):575–582CrossRefPubMed

24.

Luks FI et al (1996) Endoscopic tracheal obstruction with an expanding device in a fetal lamb model: preliminary considerations. Fetal Diagn Ther 11(1):67–71CrossRefPubMed

25.

De Lorimier AA (1967) Hypoplastic lungs in fetal lambs with surgically produced congenital diaphragmatic hernia. Surgery 62:12–17

26.

Olivet RT et al (1978) Hemodynamics of congenital diaphragmatic hernia in lambs. J Pediatr Surg 13(3):231–235CrossRefPubMed

27.

Kent GM et al (1972) Hemodynamic and pulmonary changes following surgical creation of a diaphragmatic hernia in fetal lambs. Surgery 72(3):427–433PubMed

28.

Harrison MR et al (1993) Correction of congenital diaphragmatic hernia in utero: VI. Hard-earned lessons. J Pediatr Surg 28(10):1411–1417 (discussion 1417–8)CrossRefPubMed

29.

Harrison MR et al (1997) Correction of congenital diaphragmatic hernia in utero VII: a prospective trial. J Pediatr Surg 32(11):1637–1642CrossRefPubMed

30.

Carmel JA, Friedman F, Adams FH (1965) Fetal tracheal ligation and lung development. Am J Dis Child 109:452–456PubMed

31.

Wilson JM, DiFiore JW, Peters CA (1993) Experimental fetal tracheal ligation prevents the pulmonary hypoplasia associated with fetal nephrectomy: possible application for congenital diaphragmatic hernia. J Pediatr Surg 28(11):1433–1439 (discussion 1439–40)CrossRefPubMed

32.

Alcorn D et al (1977) Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung. J Anat 123(Pt 3):649–660PubMedPubMedCentral

33.

Beierle EA, Langham MR Jr, Cassin S (1996) In utero lung growth of fetal sheep with diaphragmatic hernia and tracheal stenosis. J Pediatr Surg 31(1):141–146 (discussion 146–7)CrossRefPubMed

34.

Bealer JF et al (1995) The ‘PLUG’ odyssey: adventures in experimental fetal tracheal occlusion. J Pediatr Surg 30(2):361–364 (discussion 364–5)CrossRefPubMed

35.

DiFiore JW et al (1994) Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia. J Pediatr Surg 29(2):248–256 (discussion 256–7)CrossRef

36.

Hedrick MH et al (1994) Plug the lung until it grows (PLUG): a new method to treat congenital diaphragmatic hernia in utero. J Pediatr Surg 29(5):612–617CrossRefPubMed

37.

Harrison MR et al (1996) Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg 31(10):1339–1348CrossRefPubMed

38.

Mychaliska GB et al (1997) Operating on placental support: the ex utero intrapartum treatment procedure. J Pediatr Surg 32(2):227–230 (discussion 230–1)CrossRef

39.

Harrison MR et al (2003) Fetoscopic temporary tracheal occlusion for congenital diaphragmatic hernia: prelude to a randomized, controlled trial. J Pediatr Surg 38(7):1012–1020CrossRefPubMed

40.

Harrison MR et al (2001) Fetoscopic temporary tracheal occlusion by means of detachable balloon for congenital diaphragmatic hernia. Am J Obstet Gynecol 185(3):730–733CrossRefPubMed

41.

Chiba T et al (2000) Balloon tracheal occlusion for congenital diaphragmatic hernia: experimental studies. J Pediatr Surg 35(11):1566–1570CrossRefPubMed

42.

Longaker MT et al (1991) Maternal outcome after open fetal surgery. A review of the first 17 human cases. Jama 265(6):737–741CrossRefPubMed

43.

Skarsgard ED et al (1996) Fetal endoscopic tracheal occlusion (‘Fetendo-PLUG’) for congenital diaphragmatic hernia. J Pediatr Surg 31(10):1335–1338CrossRefPubMed

44.

Estes JM et al (1992) Fetoscopic surgery for the treatment of congenital anomalies. J Pediatr Surg 27(8):950–954CrossRefPubMed

45.

VanderWall KJ et al (1997) Fetendo-clip: a fetal endoscopic tracheal clip procedure in a human fetus. J Pediatr Surg 32(7):970–972CrossRefPubMed

46.

Deprest J, Gratacos E, Nicolaides KH (2004) Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: evolution of a technique and preliminary results. Ultrasound Obstet Gynecol 24(2):121–126CrossRefPubMed

47.

Harrison MR et al (1998) Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis (liver herniation and low lung-to-head ratio) can be saved by fetoscopic temporary tracheal occlusion. J Pediatr Surg 33(7):1017–1022 (discussion 1022–3)CrossRefPubMed

48.

Flake AW et al (2000) Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases. Am J Obstet Gynecol 183(5):1059–1066CrossRefPubMed

49.

Harrison MR et al (2003) A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med 349(20):1916–1924CrossRefPubMed

50.

De Lia JE, Cruikshank DP, Keye WR Jr (1990) Fetoscopic neodymium: YAG laser occlusion of placental vessels in severe twin–twin transfusion syndrome. Obstet Gynecol 75(6):1046–1053PubMed

51.

Ville Y et al (1995) Preliminary experience with endoscopic laser surgery for severe twin–twin transfusion syndrome. N Engl J Med 332(4):224–227CrossRefPubMed

52.

Deprest J et al (2005) Fetal intervention for congenital diaphragmatic hernia: the European experience. Semin Perinatol 29(2):94–103CrossRefPubMed

53.

Jani JC et al (2009) Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion. Ultrasound Obstet Gynecol 34(3):304–310CrossRefPubMed

54.

Ruano R et al (2012) A randomized controlled trial of fetal endoscopic tracheal occlusion versus postnatal management of severe isolated congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 39(1):20–27CrossRefPubMed

55.

Ruano R et al (2011) Comparison between fetal endoscopic tracheal occlusion using a 1.0-mm fetoscope and prenatal expectant management in severe congenital diaphragmatic hernia. Fetal Diagn Ther 29(1):64–70CrossRefPubMed

56.

Peralta CF et al (2011) Fetoscopic endotracheal occlusion for severe isolated diaphragmatic hernia: initial experience from a single clinic in Brazil. Fetal Diagn Ther 29(1):71–77CrossRefPubMed

57.

Belfort MA et al (2017) Feasibility and outcomes of fetoscopic tracheal occlusion for severe left diaphragmatic hernia. Obstet Gynecol 129(1):20–29CrossRefPubMed

58.

Kutasy B et al (2016) Antenatal retinoic acid administration increases trophoblastic retinol-binding protein dependent retinol transport in the nitrofen model of congenital diaphragmatic hernia. Pediatr Res 79(4):614–620CrossRefPubMed

59.

Montedonico S et al (2008) Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg 43(3):500–507CrossRefPubMed

60.

Baptista MJ et al (2005) Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia. J Pediatr Surg 40(4):658–665CrossRefPubMed

61.

Oshiro T et al (2005) Differential effects of vitamin A on fetal lung growth and diaphragmatic formation in nitrofen-induced rat model. Pulm Pharmacol Ther 18(3):155–164CrossRefPubMed

62.

Schmidt AF et al (2012) Prenatal retinoic acid improves lung vascularization and VEGF expression in CDH rat. Am J Obstet Gynecol 207(1):76-e25CrossRef

63.

Thebaud B et al (1999) Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am J Physiol 277(2 Pt 1):L423–L429

64.

Gallot D et al (2008) Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model. Pediatr Pulmonol 43(6):594–603CrossRefPubMed

65.

Lewis NA et al (2011) Late administration of antenatal vitamin A promotes pulmonary structural maturation and improves ventilation in the lamb model of congenital diaphragmatic hernia. Pediatr Surg Int 27(2):119–124CrossRefPubMed

66.

Eastwood MP et al (2015) Medical interventions to reverse pulmonary hypoplasia in the animal model of congenital diaphragmatic hernia: a systematic review. Pediatr Pulmonol 50(8):820–838CrossRefPubMed

67.

Tzimas G, Nau H (2001) The role of metabolism and toxicokinetics in retinoid teratogenesis. Curr Pharm Des 7(9):803–831CrossRefPubMed

68.

Losty PD et al (1995) Prenatal hormonal therapy improves pulmonary compliance in the nitrofen-induced CDH rat model. J Pediatr Surg 30(3):420–426CrossRefPubMed

69.

Davey MG et al (2006) Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion. Pediatr Res 60(2):131–135CrossRefPubMed

70.

Davey M et al (2007) Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy. Am J Obstet Gynecol 197(4):381-e1CrossRef

71.

Grivell RM, Andersen C, Dodd JM (2015) Prenatal interventions for congenital diaphragmatic hernia for improving outcomes. Cochrane Database Syst Rev (11)

72.

Lally KP et al (2006) Corticosteroids for fetuses with congenital diaphragmatic hernia: can we show benefit? J Pediatr Surg 41(4):668–674 (discussion 668–74)CrossRef

73.

Luong C et al (2011) Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 123(19):2120–2131CrossRefPubMed

74.

Burgos CM et al (2016) Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr Res 80(4):577–585CrossRefPubMed

75.

Mous DS et al (2016) Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 311(4):L734–L742CrossRef

76.

Russo FM et al (2016) Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia. Thorax 71(6):517–525CrossRefPubMed

77.

Russo FM et al (2017) Current and future antenatal management of isolated congenital diaphragmatic hernia. Semin Fetal Neonatal Med 22(6):383–390CrossRefPubMed

Titel: Prenatal intervention for the management of congenital diaphragmatic hernia
verfasst von: Mariatu A. Verla
Candace C. Style
Oluyinka O. Olutoye
Publikationsdatum: 30.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 6/2018
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4270-0

Neu im Fachgebiet Pädiatrie

16.04.2024 | Störungen der Geschlechtsidentität | Nachrichten

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Prenatal intervention for the management of congenital diaphragmatic hernia

Abstract

Neu im Fachgebiet Pädiatrie

Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Komplexes Krankheitsbild zwischen Haut und Lunge – und das mit 13 Jahren

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Pädiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2018

Accuracy and impact of prenatal diagnosis in infants with omphalocele

Weekend vs. weekday appendectomy for complicated appendicitis, effects on outcomes and operative approach

Implications of non-accidental trauma on resource utilization and outcomes

Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review

Harnessing medical student power in global surgery research

Segmental reversal of distal small intestine in short bowel syndrome: a study on the influence on postoperative weight and intestinal topography in piglets

Neu im Fachgebiet Pädiatrie

Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Komplexes Krankheitsbild zwischen Haut und Lunge – und das mit 13 Jahren

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Pädiatrie