Skip to main content
Erschienen in: Current Anesthesiology Reports 2/2020

08.04.2020 | Blood Management (KA Tanaka, Section Editor)

Preoperative Anemia Management: What’s New in 2020?

verfasst von: Daniel A. Rubinger, Christine Cahill, Andy Ngo, Marjorie Gloff, Majed A. Refaai

Erschienen in: Current Anesthesiology Reports | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

The purpose of this article is to review the relevant evidence regarding the clinical impact of preoperative anemia, current methods of identifying anemia in the surgical population, and the current and upcoming evidence for the treatment modalities targeting preoperative anemia.

Recent Findings

Preoperative anemia continues to be identified as a contributor to poor outcomes in the surgical population. Identifying anemia typically starts with hemoglobin and mean corpuscular volume. Recent laboratories have also started using iron studies with serum ferritin and transferrin saturation. Oral and IV iron have demonstrated efficacy in treating preoperative anemia in terms of increasing hemoglobin preoperatively and reducing allogeneic blood transfusions. However, few studies have demonstrated an impact on patient outcomes, morbidity, and mortality. Additionally, several meta-analyses have demonstrated the benefit of adding erythropoietin-stimulating agents to improve anemia.

Summary

Preoperative anemia is very common and is thought to be a contributor to poor outcomes. IV iron is currently recommended by several guidelines as the primary treatment modality for preoperative anemia. Two ongoing studies hope to provide clarity on the effect of IV iron on patient outcomes including morbidity and mortality in cardiac and non-cardiac surgical populations.
Literatur
1.
Zurück zum Zitat Goodnough LT, Nissenson AR. Anemia and its clinical consequences in patients with chronic diseases. Am J Med. 2004;116(Suppl 7A):1s–2s.PubMedCrossRef Goodnough LT, Nissenson AR. Anemia and its clinical consequences in patients with chronic diseases. Am J Med. 2004;116(Suppl 7A):1s–2s.PubMedCrossRef
2.
Zurück zum Zitat • Le CH. The prevalence of anemia and moderate-severe anemia in the US population (NHANES 2003-2012). PLoS One. 2016;11(11):e0166635. Identification of the prevalence of anemia in the general US population.PubMedPubMedCentralCrossRef • Le CH. The prevalence of anemia and moderate-severe anemia in the US population (NHANES 2003-2012). PLoS One. 2016;11(11):e0166635. Identification of the prevalence of anemia in the general US population.PubMedPubMedCentralCrossRef
3.
Zurück zum Zitat Migone De Amicis M, Poggiali E, Motta I, Minonzio F, Fabio G, Hu C, et al. Anemia in elderly hospitalized patients: prevalence and clinical impact. Intern Emerg Med. 2015;10(5):581–6.PubMedCrossRef Migone De Amicis M, Poggiali E, Motta I, Minonzio F, Fabio G, Hu C, et al. Anemia in elderly hospitalized patients: prevalence and clinical impact. Intern Emerg Med. 2015;10(5):581–6.PubMedCrossRef
4.
Zurück zum Zitat Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res. 2009;130(5):627–33.PubMed Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res. 2009;130(5):627–33.PubMed
5.
Zurück zum Zitat Marahatta R. Study of anaemia in pregnancy and its outcome in Nepal Medical College Teaching Hospital, Kathmandu, Nepal. Nepal Medical College journal : NMCJ. 2007;9(4):270–4.PubMed Marahatta R. Study of anaemia in pregnancy and its outcome in Nepal Medical College Teaching Hospital, Kathmandu, Nepal. Nepal Medical College journal : NMCJ. 2007;9(4):270–4.PubMed
6.
Zurück zum Zitat Sim YE, Wee HE, Ang AL, Ranjakunalan N, Ong BC, Abdullah HR. Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. PLoS One. 2017;12(8):e0182543.PubMedPubMedCentralCrossRef Sim YE, Wee HE, Ang AL, Ranjakunalan N, Ong BC, Abdullah HR. Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. PLoS One. 2017;12(8):e0182543.PubMedPubMedCentralCrossRef
7.
Zurück zum Zitat • Padmanabhan H, Siau K, Curtis J, Ng A, Menon S, Luckraz H, et al. Preoperative anemia and outcomes in cardiovascular surgery: systematic review and meta-analysis. Ann Thorac Surg. 2019;108(6):1840–8. Meta-analysis identifying anemia as a poor outcome in patients undergoing cardiac surgery.PubMedCrossRef • Padmanabhan H, Siau K, Curtis J, Ng A, Menon S, Luckraz H, et al. Preoperative anemia and outcomes in cardiovascular surgery: systematic review and meta-analysis. Ann Thorac Surg. 2019;108(6):1840–8. Meta-analysis identifying anemia as a poor outcome in patients undergoing cardiac surgery.PubMedCrossRef
8.
Zurück zum Zitat Klein AA, Collier TJ, Brar MS, Evans C, Hallward G, Fletcher SN, et al. The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit. Anaesthesia. 2016;71(6):627–35.PubMedCrossRef Klein AA, Collier TJ, Brar MS, Evans C, Hallward G, Fletcher SN, et al. The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit. Anaesthesia. 2016;71(6):627–35.PubMedCrossRef
9.
Zurück zum Zitat Remacha AF, Wright I, Fernandez-Jimenez MC, Toxqui L, Blanco-Rojo R, Moreno G, et al. Vitamin B12 and folate levels increase during treatment of iron deficiency anaemia in young adult woman. Int J Lab Hematol. 2015;37(5):641–8.PubMedCrossRef Remacha AF, Wright I, Fernandez-Jimenez MC, Toxqui L, Blanco-Rojo R, Moreno G, et al. Vitamin B12 and folate levels increase during treatment of iron deficiency anaemia in young adult woman. Int J Lab Hematol. 2015;37(5):641–8.PubMedCrossRef
10.
Zurück zum Zitat •• Mueller MM, Van Remoortel H, Meybohm P, Aranko K, Aubron C, Burger R, et al. Patient blood management: recommendations from the 2018 Frankfurt consensus conference. Jama. 2019;321(10):983–97. Recommendations from an internation consensus conference on patient blood management. There was general agreement that preoperative anemia should be formally evaluated and treated in surgical patients. PubMedCrossRef •• Mueller MM, Van Remoortel H, Meybohm P, Aranko K, Aubron C, Burger R, et al. Patient blood management: recommendations from the 2018 Frankfurt consensus conference. Jama. 2019;321(10):983–97. Recommendations from an internation consensus conference on patient blood management. There was general agreement that preoperative anemia should be formally evaluated and treated in surgical patients. PubMedCrossRef
11.
Zurück zum Zitat Deepak B, Balaji A, Pramod A, Sujit K, Savani F, Bapu K, et al. The prevalence and impact of preoperative anemia in patients undergoing cardiac surgery for rheumatic heart disease. J Cardiothorac Vasc Anesth. 2016;30(4):896–900.PubMedCrossRef Deepak B, Balaji A, Pramod A, Sujit K, Savani F, Bapu K, et al. The prevalence and impact of preoperative anemia in patients undergoing cardiac surgery for rheumatic heart disease. J Cardiothorac Vasc Anesth. 2016;30(4):896–900.PubMedCrossRef
12.
Zurück zum Zitat LaPar DJ, Hawkins RB, McMurry TL, Isbell JM, Rich JB, Speir AM, et al. Preoperative anemia versus blood transfusion: which is the culprit for worse outcomes in cardiac surgery? J Thorac Cardiovasc Surg. 2018;156(1):66–74.e2.PubMedPubMedCentralCrossRef LaPar DJ, Hawkins RB, McMurry TL, Isbell JM, Rich JB, Speir AM, et al. Preoperative anemia versus blood transfusion: which is the culprit for worse outcomes in cardiac surgery? J Thorac Cardiovasc Surg. 2018;156(1):66–74.e2.PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Miceli A, Romeo F, Glauber M, de Siena PM, Caputo M, Angelini GD. Preoperative anemia increases mortality and postoperative morbidity after cardiac surgery. J Cardiothorac Surg. 2014;9:137.PubMedPubMedCentralCrossRef Miceli A, Romeo F, Glauber M, de Siena PM, Caputo M, Angelini GD. Preoperative anemia increases mortality and postoperative morbidity after cardiac surgery. J Cardiothorac Surg. 2014;9:137.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Oprea AD, Del Rio JM, Cooter M, Green CL, Karhausen JA, Nailer P, et al. Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study. Can J Anaesth. 2018;65(1):46–59.PubMedCrossRef Oprea AD, Del Rio JM, Cooter M, Green CL, Karhausen JA, Nailer P, et al. Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study. Can J Anaesth. 2018;65(1):46–59.PubMedCrossRef
15.
Zurück zum Zitat Meybohm P, Westphal S, Ravn HB, Ranucci M, Agarwal S, Choorapoikayil S, et al. Perioperative anemia management as part of PBM in cardiac surgery - a narrative updated review. J Cardiothorac Vasc Anesth. 2019. Meybohm P, Westphal S, Ravn HB, Ranucci M, Agarwal S, Choorapoikayil S, et al. Perioperative anemia management as part of PBM in cardiac surgery - a narrative updated review. J Cardiothorac Vasc Anesth. 2019.
16.
Zurück zum Zitat • Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg. 2015;102(11):1314–24. Large meta-analysis showing that preoperative anemia is associated with increased mortality.PubMedCrossRef • Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg. 2015;102(11):1314–24. Large meta-analysis showing that preoperative anemia is associated with increased mortality.PubMedCrossRef
17.
Zurück zum Zitat • Karkouti K, Wijeysundera DN, Beattie WS. Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study. Circulation. 2008;117(4):478–84 Major study identifying preoperative anemia.PubMedCrossRef • Karkouti K, Wijeysundera DN, Beattie WS. Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study. Circulation. 2008;117(4):478–84 Major study identifying preoperative anemia.PubMedCrossRef
18.
Zurück zum Zitat Shavit L, Hitti S, Silberman S, Tauber R, Merin O, Lifschitz M, et al. Preoperative hemoglobin and outcomes in patients with CKD undergoing cardiac surgery. Clin J Am Soc Nephrol. 2014;9(9):1536–44.PubMedPubMedCentralCrossRef Shavit L, Hitti S, Silberman S, Tauber R, Merin O, Lifschitz M, et al. Preoperative hemoglobin and outcomes in patients with CKD undergoing cardiac surgery. Clin J Am Soc Nephrol. 2014;9(9):1536–44.PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Beattie WS, Karkouti K, Wijeysundera DN, Tait G. Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study. Anesthesiology. 2009;110(3):574–81.PubMedCrossRef Beattie WS, Karkouti K, Wijeysundera DN, Tait G. Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study. Anesthesiology. 2009;110(3):574–81.PubMedCrossRef
20.
Zurück zum Zitat Smilowitz NR, Oberweis BS, Nukala S, Rosenberg A, Zhao S, Xu J, et al. Association between anemia, bleeding, and transfusion with long-term mortality following noncardiac surgery. Am J Med. 2016;129(3):315–23.e2.PubMedCrossRef Smilowitz NR, Oberweis BS, Nukala S, Rosenberg A, Zhao S, Xu J, et al. Association between anemia, bleeding, and transfusion with long-term mortality following noncardiac surgery. Am J Med. 2016;129(3):315–23.e2.PubMedCrossRef
21.
Zurück zum Zitat Elsamadicy AA, Adogwa O, Vuong VD, Mehta AI, Vasquez RA, Cheng J, et al. Association of intraoperative blood transfusions on postoperative complications, 30-day readmission rates, and 1-year patient-reported outcomes. Spine. 2017;42(8):610–5.PubMedCrossRef Elsamadicy AA, Adogwa O, Vuong VD, Mehta AI, Vasquez RA, Cheng J, et al. Association of intraoperative blood transfusions on postoperative complications, 30-day readmission rates, and 1-year patient-reported outcomes. Spine. 2017;42(8):610–5.PubMedCrossRef
22.
Zurück zum Zitat Carson JL, Triulzi DJ, Ness PM. Indications for and adverse effects of red-cell transfusion. N Engl J Med. 2017;377(13):1261–72.PubMedCrossRef Carson JL, Triulzi DJ, Ness PM. Indications for and adverse effects of red-cell transfusion. N Engl J Med. 2017;377(13):1261–72.PubMedCrossRef
23.
Zurück zum Zitat Isbister JP, Shander A, Spahn DR, Erhard J, Farmer SL, Hofmann A. Adverse blood transfusion outcomes: establishing causation. Transfus Med Rev. 2011;25(2):89–101.PubMedCrossRef Isbister JP, Shander A, Spahn DR, Erhard J, Farmer SL, Hofmann A. Adverse blood transfusion outcomes: establishing causation. Transfus Med Rev. 2011;25(2):89–101.PubMedCrossRef
24.
Zurück zum Zitat Shander A, Knight K, Thurer R, Adamson J, Spence R. Prevalence and outcomes of anemia in surgery: a systematic review of the literature. Am J Med. 2004;116(Suppl 7A):58s–69s.PubMedCrossRef Shander A, Knight K, Thurer R, Adamson J, Spence R. Prevalence and outcomes of anemia in surgery: a systematic review of the literature. Am J Med. 2004;116(Suppl 7A):58s–69s.PubMedCrossRef
25.
Zurück zum Zitat Goodnough LT, Maniatis A, Earnshaw P, Benoni G, Beris P, Bisbe E, et al. Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J Anaesth. 2011;106(1):13–22.PubMedPubMedCentralCrossRef Goodnough LT, Maniatis A, Earnshaw P, Benoni G, Beris P, Bisbe E, et al. Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J Anaesth. 2011;106(1):13–22.PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Gupta PK, Sundaram A, Mactaggart JN, Johanning JM, Gupta H, Fang X, et al. Preoperative anemia is an independent predictor of postoperative mortality and adverse cardiac events in elderly patients undergoing elective vascular operations. Ann Surg. 2013;258(6):1096–102.PubMedCrossRef Gupta PK, Sundaram A, Mactaggart JN, Johanning JM, Gupta H, Fang X, et al. Preoperative anemia is an independent predictor of postoperative mortality and adverse cardiac events in elderly patients undergoing elective vascular operations. Ann Surg. 2013;258(6):1096–102.PubMedCrossRef
28.
Zurück zum Zitat Munoz M, Gomez-Ramirez S, Campos A, Ruiz J, Liumbruno GM. Pre-operative anaemia: prevalence, consequences and approaches to management. Blood Transfus. 2015;13(3):370–9.PubMedPubMedCentral Munoz M, Gomez-Ramirez S, Campos A, Ruiz J, Liumbruno GM. Pre-operative anaemia: prevalence, consequences and approaches to management. Blood Transfus. 2015;13(3):370–9.PubMedPubMedCentral
29.
Zurück zum Zitat Guinn NR, Guercio JR, Hopkins TJ, Grimsley A, Kurian DJ, Jimenez MI, et al. How do we develop and implement a preoperative anemia clinic designed to improve perioperative outcomes and reduce cost? Transfusion. 2016;56(2):297–303.PubMedCrossRef Guinn NR, Guercio JR, Hopkins TJ, Grimsley A, Kurian DJ, Jimenez MI, et al. How do we develop and implement a preoperative anemia clinic designed to improve perioperative outcomes and reduce cost? Transfusion. 2016;56(2):297–303.PubMedCrossRef
30.
Zurück zum Zitat Pujol-Nicolas A, Morrison R, Casson C, Khan S, Marriott A, Tiplady C, et al. Preoperative screening and intervention for mild anemia with low iron stores in elective hip and knee arthroplasty. Transfusion. 2017;57(12):3049–57.PubMedCrossRef Pujol-Nicolas A, Morrison R, Casson C, Khan S, Marriott A, Tiplady C, et al. Preoperative screening and intervention for mild anemia with low iron stores in elective hip and knee arthroplasty. Transfusion. 2017;57(12):3049–57.PubMedCrossRef
31.
Zurück zum Zitat Burton BN, A'Court AM, Brovman EY, Scott MJ, Urman RD, Gabriel RA. Optimizing preoperative anemia to improve patient outcomes. Anesthesiol Clin. 2018;36(4):701–13.PubMedCrossRef Burton BN, A'Court AM, Brovman EY, Scott MJ, Urman RD, Gabriel RA. Optimizing preoperative anemia to improve patient outcomes. Anesthesiol Clin. 2018;36(4):701–13.PubMedCrossRef
32.
Zurück zum Zitat Jin L, Kapadia TY, Von Gehr A, Rosas E, Bird JB, Ramaswamy D, et al. Feasibility of a preoperative anemia protocol in a large integrated health care system. Perm J. 2019;23. Jin L, Kapadia TY, Von Gehr A, Rosas E, Bird JB, Ramaswamy D, et al. Feasibility of a preoperative anemia protocol in a large integrated health care system. Perm J. 2019;23.
33.
Zurück zum Zitat Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 2006;107(5):1747–50.PubMedPubMedCentralCrossRef Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 2006;107(5):1747–50.PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat Short MW, Domagalski JE. Iron deficiency anemia: evaluation and management. Am Fam Physician. 2013;87(2):98–104.PubMed Short MW, Domagalski JE. Iron deficiency anemia: evaluation and management. Am Fam Physician. 2013;87(2):98–104.PubMed
35.
Zurück zum Zitat Goodnough LT, Shander A, Spivak JL, Waters JH, Friedman AJ, Carson JL, et al. Detection, evaluation, and management of anemia in the elective surgical patient. Anesth Analg. 2005;101(6):1858–61.PubMedCrossRef Goodnough LT, Shander A, Spivak JL, Waters JH, Friedman AJ, Carson JL, et al. Detection, evaluation, and management of anemia in the elective surgical patient. Anesth Analg. 2005;101(6):1858–61.PubMedCrossRef
36.
37.
Zurück zum Zitat Goodnough L, Comin-Colet J, Leal-Noval S, Ozawa S, Takere J, Henry D, et al. Management of anemia in patients with congestive heart failure. Am J Hematol. 2017;92(1):88–93.CrossRef Goodnough L, Comin-Colet J, Leal-Noval S, Ozawa S, Takere J, Henry D, et al. Management of anemia in patients with congestive heart failure. Am J Hematol. 2017;92(1):88–93.CrossRef
38.
Zurück zum Zitat Brugnara C, Zurakowski D, DiCanzio J, Boyd T, Platt O. Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA. 1999;281(23):2225–30.PubMedCrossRef Brugnara C, Zurakowski D, DiCanzio J, Boyd T, Platt O. Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA. 1999;281(23):2225–30.PubMedCrossRef
39.
Zurück zum Zitat Mateos ME, De-la-Cruz J, Lopez-Laso E, Valdes MD, Nogales A. Reticulocyte hemoglobin content for the diagnosis of iron deficiency. J Pediatr Hematol Oncol. 2008;30(7):539–42.PubMedCrossRef Mateos ME, De-la-Cruz J, Lopez-Laso E, Valdes MD, Nogales A. Reticulocyte hemoglobin content for the diagnosis of iron deficiency. J Pediatr Hematol Oncol. 2008;30(7):539–42.PubMedCrossRef
40.
Zurück zum Zitat Kuehn D, Roberts SS, Olsen CH, Harvey DN, Charnock KM, Brewer BD, et al. Reticulocyte hemoglobin content testing for iron deficiency in healthy toddlers. Mil Med. 2012;177(1):91–5.PubMedCrossRef Kuehn D, Roberts SS, Olsen CH, Harvey DN, Charnock KM, Brewer BD, et al. Reticulocyte hemoglobin content testing for iron deficiency in healthy toddlers. Mil Med. 2012;177(1):91–5.PubMedCrossRef
41.
Zurück zum Zitat Thomas C, Kirschbaum A, Boehm D, Thomas L. The diagnostic plot: a concept for identifying different states of iron deficiency and monitoring the response to epoetin therapy. Med Oncol. 2006;23(1):23–36.PubMedCrossRef Thomas C, Kirschbaum A, Boehm D, Thomas L. The diagnostic plot: a concept for identifying different states of iron deficiency and monitoring the response to epoetin therapy. Med Oncol. 2006;23(1):23–36.PubMedCrossRef
42.
Zurück zum Zitat Enko D, Wallner F, von- Goedecke A, Hirschmugl C, Auersperg V, Halwachs-Baumann G. The impact of an algorithm-guided management of preoperative anemia in perioperative hemoglobin level and transfusion of major orthopedic surgery patients. Anemia. 2013;2013:641876.PubMedPubMedCentralCrossRef Enko D, Wallner F, von- Goedecke A, Hirschmugl C, Auersperg V, Halwachs-Baumann G. The impact of an algorithm-guided management of preoperative anemia in perioperative hemoglobin level and transfusion of major orthopedic surgery patients. Anemia. 2013;2013:641876.PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Gross JB. Estimating allowable blood loss: corrected for dilution. Anesthesiology. 1983;58(3):277–80.PubMedCrossRef Gross JB. Estimating allowable blood loss: corrected for dilution. Anesthesiology. 1983;58(3):277–80.PubMedCrossRef
44.
Zurück zum Zitat Practice advisory for preanesthesia evaluation: an updated report by the American Society of Anesthesiologists Task Force on preanesthesia evaluation. Anesthesiology. 2012;116(3):522–38. Practice advisory for preanesthesia evaluation: an updated report by the American Society of Anesthesiologists Task Force on preanesthesia evaluation. Anesthesiology. 2012;116(3):522–38.
45.
Zurück zum Zitat Munoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 2017;72(2):233–47.PubMedCrossRef Munoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 2017;72(2):233–47.PubMedCrossRef
46.
Zurück zum Zitat Kotze A, Harris A, Baker C, Iqbal T, Lavies N, Richards T, et al. British committee for standards in haematology guidelines on the identification and management of pre-operative anaemia. Br J Haematol. 2015;171(3):322–31.PubMedCrossRef Kotze A, Harris A, Baker C, Iqbal T, Lavies N, Richards T, et al. British committee for standards in haematology guidelines on the identification and management of pre-operative anaemia. Br J Haematol. 2015;171(3):322–31.PubMedCrossRef
47.
Zurück zum Zitat Fischer DP, Zacharowski KD, Muller MM, Geisen C, Seifried E, Muller H, et al. Patient blood management implementation strategies and their effect on physicians’ risk perception, clinical knowledge and perioperative practice - the frankfurt experience. Transfus Med Hemother. 2015;42(2):91–7.PubMedPubMedCentralCrossRef Fischer DP, Zacharowski KD, Muller MM, Geisen C, Seifried E, Muller H, et al. Patient blood management implementation strategies and their effect on physicians’ risk perception, clinical knowledge and perioperative practice - the frankfurt experience. Transfus Med Hemother. 2015;42(2):91–7.PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Aronson S, Grocott MPW, Mythen MMG. Preoperative patient preparation, programs, and education in the United States: state of the art, state of the science, and state of affairs. Adv Anesth. 2019;37:127–43.PubMedCrossRef Aronson S, Grocott MPW, Mythen MMG. Preoperative patient preparation, programs, and education in the United States: state of the art, state of the science, and state of affairs. Adv Anesth. 2019;37:127–43.PubMedCrossRef
50.
Zurück zum Zitat Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MB. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women. Haematologica. 2019. Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MB. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women. Haematologica. 2019.
51.
Zurück zum Zitat Fernandez-Gaxiola AC, De-Regil LM. Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. Cochrane Database Syst Rev. 2019;1:Cd009218.PubMed Fernandez-Gaxiola AC, De-Regil LM. Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. Cochrane Database Syst Rev. 2019;1:Cd009218.PubMed
52.
Zurück zum Zitat Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015;126(17):1981–9.PubMedCrossRef Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015;126(17):1981–9.PubMedCrossRef
54.
Zurück zum Zitat Lidder PG, Sanders G, Whitehead E, Douie WJ, Mellor N, Lewis SJ, et al. Pre-operative oral iron supplementation reduces blood transfusion in colorectal surgery - a prospective, randomised, controlled trial. Ann R Coll Surg Engl. 2007;89(4):418–21.PubMedPubMedCentralCrossRef Lidder PG, Sanders G, Whitehead E, Douie WJ, Mellor N, Lewis SJ, et al. Pre-operative oral iron supplementation reduces blood transfusion in colorectal surgery - a prospective, randomised, controlled trial. Ann R Coll Surg Engl. 2007;89(4):418–21.PubMedPubMedCentralCrossRef
55.
Zurück zum Zitat Okuyama M, Ikeda K, Shibata T, Tsukahara Y, Kitada M, Shimano T. Preoperative iron supplementation and intraoperative transfusion during colorectal cancer surgery. Surg Today. 2005;35(1):36–40.PubMedCrossRef Okuyama M, Ikeda K, Shibata T, Tsukahara Y, Kitada M, Shimano T. Preoperative iron supplementation and intraoperative transfusion during colorectal cancer surgery. Surg Today. 2005;35(1):36–40.PubMedCrossRef
56.
Zurück zum Zitat Quinn M, Drummond RJ, Ross F, Murray J, Murphy J, Macdonald A. Short course pre-operative ferrous sulphate supplementation--is it worthwhile in patients with colorectal cancer? Ann R Coll Surg Engl. 2010;92(7):569–72.PubMedPubMedCentralCrossRef Quinn M, Drummond RJ, Ross F, Murray J, Murphy J, Macdonald A. Short course pre-operative ferrous sulphate supplementation--is it worthwhile in patients with colorectal cancer? Ann R Coll Surg Engl. 2010;92(7):569–72.PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Cuenca J, Garcia-Erce JA, Martinez F, Cardona R, Perez-Serrano L, Munoz M. Preoperative haematinics and transfusion protocol reduce the need for transfusion after total knee replacement. Int J Surg. 2007;5(2):89–94.PubMedCrossRef Cuenca J, Garcia-Erce JA, Martinez F, Cardona R, Perez-Serrano L, Munoz M. Preoperative haematinics and transfusion protocol reduce the need for transfusion after total knee replacement. Int J Surg. 2007;5(2):89–94.PubMedCrossRef
58.
Zurück zum Zitat Kotze A, Carter LA, Scally AJ. Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle. Br J Anaesth. 2012;108(6):943–52.PubMedCrossRef Kotze A, Carter LA, Scally AJ. Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle. Br J Anaesth. 2012;108(6):943–52.PubMedCrossRef
59.
Zurück zum Zitat Scardino M, Di Matteo B, Martorelli F, Tanzi D, Kon E, D'Amato T. Improved patient blood management and cost saving in hip replacement surgery through the implementation of pre-operative Sucrosomial® iron supplementation: a quality improvement assessment study. Int Orthop. 2019;43(1):39–46.PubMedCrossRef Scardino M, Di Matteo B, Martorelli F, Tanzi D, Kon E, D'Amato T. Improved patient blood management and cost saving in hip replacement surgery through the implementation of pre-operative Sucrosomial® iron supplementation: a quality improvement assessment study. Int Orthop. 2019;43(1):39–46.PubMedCrossRef
60.
Zurück zum Zitat Gomez-Ramirez S, Bisbe E, Shander A, Spahn DR, Munoz M. Management of perioperative iron deficiency anemia. Acta Haematol. 2019;142(1):21–9.PubMedCrossRef Gomez-Ramirez S, Bisbe E, Shander A, Spahn DR, Munoz M. Management of perioperative iron deficiency anemia. Acta Haematol. 2019;142(1):21–9.PubMedCrossRef
61.
Zurück zum Zitat •• Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management*. Anesthesiology. 2015;122(2):241–75. ASA guidelines on management of anemia in the surgical population. •• Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management*. Anesthesiology. 2015;122(2):241–75. ASA guidelines on management of anemia in the surgical population.
62.
Zurück zum Zitat Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood. 2000;96(3):823–33.PubMedCrossRef Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood. 2000;96(3):823–33.PubMedCrossRef
63.
Zurück zum Zitat • Banerjee S, McCormack S. CADTH rapid response reports. Intravenous iron preparations for patients undergoing elective surgery: a review of clinical effectiveness, cost-effectiveness, and guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health Copyright (c) 2019. Can Agency Drugs Technol Health. 2019; Canadian guidelines evaluating evidence for IV iron preparations in treating preoperative anemia. • Banerjee S, McCormack S. CADTH rapid response reports. Intravenous iron preparations for patients undergoing elective surgery: a review of clinical effectiveness, cost-effectiveness, and guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health Copyright (c) 2019. Can Agency Drugs Technol Health. 2019; Canadian guidelines evaluating evidence for IV iron preparations in treating preoperative anemia.
64.
Zurück zum Zitat Serrano-Trenas JA, Ugalde PF, Cabello LM, Chofles LC, Lazaro PS, Benitez PC. Role of perioperative intravenous iron therapy in elderly hip fracture patients: a single-center randomized controlled trial. Transfusion. 2011;51(1):97–104.PubMedCrossRef Serrano-Trenas JA, Ugalde PF, Cabello LM, Chofles LC, Lazaro PS, Benitez PC. Role of perioperative intravenous iron therapy in elderly hip fracture patients: a single-center randomized controlled trial. Transfusion. 2011;51(1):97–104.PubMedCrossRef
65.
Zurück zum Zitat Froessler B, Palm P, Weber I, Hodyl NA, Singh R, Murphy EM. The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial. Ann Surg. 2016;264(1):41–6.PubMedCrossRef Froessler B, Palm P, Weber I, Hodyl NA, Singh R, Murphy EM. The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial. Ann Surg. 2016;264(1):41–6.PubMedCrossRef
66.
Zurück zum Zitat Bernabeu-Wittel M, Romero M, Ollero-Baturone M, Aparicio R, Murcia-Zaragoza J, Rincon-Gomez M, et al. Ferric carboxymaltose with or without erythropoietin in anemic patients with hip fracture: a randomized clinical trial. Transfusion. 2016;56(9):2199–211.PubMedCrossRef Bernabeu-Wittel M, Romero M, Ollero-Baturone M, Aparicio R, Murcia-Zaragoza J, Rincon-Gomez M, et al. Ferric carboxymaltose with or without erythropoietin in anemic patients with hip fracture: a randomized clinical trial. Transfusion. 2016;56(9):2199–211.PubMedCrossRef
67.
Zurück zum Zitat Keeler BD, Dickson EA, Simpson JA, Ng O, Padmanabhan H, Brookes MJ, et al. The impact of pre-operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer-associated anaemia (IVICA) trial. Anaesthesia. 2019;74(6):714–25.PubMedCrossRef Keeler BD, Dickson EA, Simpson JA, Ng O, Padmanabhan H, Brookes MJ, et al. The impact of pre-operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer-associated anaemia (IVICA) trial. Anaesthesia. 2019;74(6):714–25.PubMedCrossRef
68.
Zurück zum Zitat Edwards TJ, Noble EJ, Durran A, Mellor N, Hosie KB. Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery. Br J Surg. 2009;96(10):1122–8.PubMedCrossRef Edwards TJ, Noble EJ, Durran A, Mellor N, Hosie KB. Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery. Br J Surg. 2009;96(10):1122–8.PubMedCrossRef
69.
Zurück zum Zitat Cuenca J, Garcia-Erce JA, Martinez AA, Solano VM, Molina J, Munoz M. Role of parenteral iron in the management of anaemia in the elderly patient undergoing displaced subcapital hip fracture repair: preliminary data. Arch Orthop Trauma Surg. 2005;125(5):342–7.PubMedCrossRef Cuenca J, Garcia-Erce JA, Martinez AA, Solano VM, Molina J, Munoz M. Role of parenteral iron in the management of anaemia in the elderly patient undergoing displaced subcapital hip fracture repair: preliminary data. Arch Orthop Trauma Surg. 2005;125(5):342–7.PubMedCrossRef
70.
Zurück zum Zitat Cuenca J, Garcia-Erce JA, Munoz M, Izuel M, Martinez AA, Herrera A. Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: a pilot study. Transfusion. 2004;44(10):1447–52.PubMedCrossRef Cuenca J, Garcia-Erce JA, Munoz M, Izuel M, Martinez AA, Herrera A. Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: a pilot study. Transfusion. 2004;44(10):1447–52.PubMedCrossRef
71.
Zurück zum Zitat Gonzalez-Porras JR, Colado E, Conde MP, Lopez T, Nieto MJ, Corral M. An individualized pre-operative blood saving protocol can increase pre-operative haemoglobin levels and reduce the need for transfusion in elective total hip or knee arthroplasty. Transfus Med. 2009;19(1):35–42.PubMedCrossRef Gonzalez-Porras JR, Colado E, Conde MP, Lopez T, Nieto MJ, Corral M. An individualized pre-operative blood saving protocol can increase pre-operative haemoglobin levels and reduce the need for transfusion in elective total hip or knee arthroplasty. Transfus Med. 2009;19(1):35–42.PubMedCrossRef
72.
Zurück zum Zitat Blanco Rubio N, Llorens Eizaguerri M, Seral Garcia B, Burillo Fuertes P, Ranera Garcia M, Albareda Albareda J. Preoperative intravenous iron as a strategy for blood saving in surgery for hip fracture. Med Clin (Barc). 2013;141(9):371–5.CrossRef Blanco Rubio N, Llorens Eizaguerri M, Seral Garcia B, Burillo Fuertes P, Ranera Garcia M, Albareda Albareda J. Preoperative intravenous iron as a strategy for blood saving in surgery for hip fracture. Med Clin (Barc). 2013;141(9):371–5.CrossRef
73.
Zurück zum Zitat Theusinger OM, Leyvraz PF, Schanz U, Seifert B, Spahn DR. Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. Anesthesiology. 2007;107(6):923–7.PubMedCrossRef Theusinger OM, Leyvraz PF, Schanz U, Seifert B, Spahn DR. Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. Anesthesiology. 2007;107(6):923–7.PubMedCrossRef
74.
Zurück zum Zitat Heschl M, Gombotz H, Haslinger-Eisterer B, Hofmann A, Bohler N, Meier J. The efficacy of pre-operative preparation with intravenous iron and/or erythropoietin in anaemic patients undergoing orthopaedic surgery: an observational study. Eur J Anaesthesiol. 2018;35(4):289–97.PubMedCrossRef Heschl M, Gombotz H, Haslinger-Eisterer B, Hofmann A, Bohler N, Meier J. The efficacy of pre-operative preparation with intravenous iron and/or erythropoietin in anaemic patients undergoing orthopaedic surgery: an observational study. Eur J Anaesthesiol. 2018;35(4):289–97.PubMedCrossRef
75.
Zurück zum Zitat Calleja JL, Delgado S, del Val A, Hervas A, Larraona JL, Teran A, et al. Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia. Int J Color Dis. 2016;31(3):543–51.CrossRef Calleja JL, Delgado S, del Val A, Hervas A, Larraona JL, Teran A, et al. Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia. Int J Color Dis. 2016;31(3):543–51.CrossRef
76.
Zurück zum Zitat Laso-Morales M, Jerico C, Gomez-Ramirez S, Castellvi J, Viso L, Roig-Martinez I, et al. Preoperative management of colorectal cancer-induced iron deficiency anemia in clinical practice: data from a large observational cohort. Transfusion. 2017;57(12):3040–8.PubMedCrossRef Laso-Morales M, Jerico C, Gomez-Ramirez S, Castellvi J, Viso L, Roig-Martinez I, et al. Preoperative management of colorectal cancer-induced iron deficiency anemia in clinical practice: data from a large observational cohort. Transfusion. 2017;57(12):3040–8.PubMedCrossRef
77.
Zurück zum Zitat Wilson MJ, Dekker JW, Bruns E, Borstlap W, Jeekel J, Zwaginga JJ, et al. Short-term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study. Transfusion. 2018;58(3):795–803.PubMedCrossRef Wilson MJ, Dekker JW, Bruns E, Borstlap W, Jeekel J, Zwaginga JJ, et al. Short-term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study. Transfusion. 2018;58(3):795–803.PubMedCrossRef
78.
Zurück zum Zitat Yoo YC, Shim JK, Kim JC, Jo YY, Lee JH, Kwak YL. Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. Anesthesiology. 2011;115(5):929–37.PubMedCrossRef Yoo YC, Shim JK, Kim JC, Jo YY, Lee JH, Kwak YL. Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. Anesthesiology. 2011;115(5):929–37.PubMedCrossRef
79.
Zurück zum Zitat Munoz M, Gomez-Ramirez S, Cuenca J, Garcia-Erce JA, Iglesias-Aparicio D, Haman-Alcober S, et al. Very-short-term perioperative intravenous iron administration and postoperative outcome in major orthopedic surgery: a pooled analysis of observational data from 2547 patients. Transfusion. 2014;54(2):289–99.PubMed Munoz M, Gomez-Ramirez S, Cuenca J, Garcia-Erce JA, Iglesias-Aparicio D, Haman-Alcober S, et al. Very-short-term perioperative intravenous iron administration and postoperative outcome in major orthopedic surgery: a pooled analysis of observational data from 2547 patients. Transfusion. 2014;54(2):289–99.PubMed
80.
Zurück zum Zitat • Ng O, Keeler BD, Mishra A, Simpson JA, Neal K, Al-Hassi HO, et al. Iron therapy for preoperative anaemia. Cochrane Database Syst Rev. 2019;12:Cd011588. Updated Cochrane systematic review analyzing evidence for iron in preoperative anemia.PubMed • Ng O, Keeler BD, Mishra A, Simpson JA, Neal K, Al-Hassi HO, et al. Iron therapy for preoperative anaemia. Cochrane Database Syst Rev. 2019;12:Cd011588. Updated Cochrane systematic review analyzing evidence for iron in preoperative anemia.PubMed
81.
Zurück zum Zitat Richards T, Clevenger B, Keidan J, Collier T, Klein AA, Anker SD, et al. PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial. Trials. 2015;16:254.PubMedPubMedCentralCrossRef Richards T, Clevenger B, Keidan J, Collier T, Klein AA, Anker SD, et al. PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial. Trials. 2015;16:254.PubMedPubMedCentralCrossRef
82.
Zurück zum Zitat Girelli D, Ugolini S, Busti F, Marchi G, Castagna A. Modern iron replacement therapy: clinical and pathophysiological insights. Int J Hematol. 2018;107(1):16–30.PubMedCrossRef Girelli D, Ugolini S, Busti F, Marchi G, Castagna A. Modern iron replacement therapy: clinical and pathophysiological insights. Int J Hematol. 2018;107(1):16–30.PubMedCrossRef
83.
Zurück zum Zitat Ishida JH, Johansen KL. Iron and infection in hemodialysis patients. Semin Dial. 2014;27(1):26–36.PubMedCrossRef Ishida JH, Johansen KL. Iron and infection in hemodialysis patients. Semin Dial. 2014;27(1):26–36.PubMedCrossRef
84.
Zurück zum Zitat Avni T, Bieber A, Grossman A, Green H, Leibovici L, Gafter-Gvili A. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin Proc. 2015;90(1):12–23.PubMedCrossRef Avni T, Bieber A, Grossman A, Green H, Leibovici L, Gafter-Gvili A. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin Proc. 2015;90(1):12–23.PubMedCrossRef
85.
Zurück zum Zitat Shin HW, Park JJ, Kim HJ, You HS, Choi SU, Lee MJ. Efficacy of perioperative intravenous iron therapy for transfusion in orthopedic surgery: a systematic review and meta-analysis. PLoS One. 2019;14(5):e0215427.PubMedPubMedCentralCrossRef Shin HW, Park JJ, Kim HJ, You HS, Choi SU, Lee MJ. Efficacy of perioperative intravenous iron therapy for transfusion in orthopedic surgery: a systematic review and meta-analysis. PLoS One. 2019;14(5):e0215427.PubMedPubMedCentralCrossRef
86.
Zurück zum Zitat Gomez-Ramirez S, Shander A, Spahn DR, Auerbach M, Liumbruno GM, Vaglio S, et al. Prevention and management of acute reactions to intravenous iron in surgical patients. Blood Transfus. 2019;17(2):137–45.PubMed Gomez-Ramirez S, Shander A, Spahn DR, Auerbach M, Liumbruno GM, Vaglio S, et al. Prevention and management of acute reactions to intravenous iron in surgical patients. Blood Transfus. 2019;17(2):137–45.PubMed
87.
Zurück zum Zitat Li Y, Yin P, Lv H, Meng Y, Zhang L, Tang P. A meta-analysis and systematic review evaluating the use of erythropoietin in total hip and knee arthroplasty. Ther Clin Risk Manag. 2018;14:1191–204.PubMedPubMedCentralCrossRef Li Y, Yin P, Lv H, Meng Y, Zhang L, Tang P. A meta-analysis and systematic review evaluating the use of erythropoietin in total hip and knee arthroplasty. Ther Clin Risk Manag. 2018;14:1191–204.PubMedPubMedCentralCrossRef
88.
Zurück zum Zitat Cho BC, Serini J, Zorrilla-Vaca A, Scott MJ, Gehrie EA, Frank SM, et al. Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis. Anesth Analg. 2019;128(5):981–92.PubMedCrossRef Cho BC, Serini J, Zorrilla-Vaca A, Scott MJ, Gehrie EA, Frank SM, et al. Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis. Anesth Analg. 2019;128(5):981–92.PubMedCrossRef
89.
Zurück zum Zitat Kei T, Mistry N, Curley G, Pavenski K, Shehata N, Tanzini RM, et al. Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta-analysis. Can J Anaesth. 2019;66(6):716–31.PubMedCrossRef Kei T, Mistry N, Curley G, Pavenski K, Shehata N, Tanzini RM, et al. Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta-analysis. Can J Anaesth. 2019;66(6):716–31.PubMedCrossRef
90.
Zurück zum Zitat Mazzeffi M, Chow JH, Tanaka K. Preoperative erythropoietin in cardiac surgery: evolving standard of care or aggregation of marginal gain? Anesth Analg. 2019;129(3):e110–e1.PubMedCrossRef Mazzeffi M, Chow JH, Tanaka K. Preoperative erythropoietin in cardiac surgery: evolving standard of care or aggregation of marginal gain? Anesth Analg. 2019;129(3):e110–e1.PubMedCrossRef
91.
Zurück zum Zitat Spahn DR, Schoenrath F, Spahn GH, Seifert B, Stein P, Theusinger OM, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. Lancet. 2019;393(10187):2201–12.PubMedCrossRef Spahn DR, Schoenrath F, Spahn GH, Seifert B, Stein P, Theusinger OM, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. Lancet. 2019;393(10187):2201–12.PubMedCrossRef
92.
Zurück zum Zitat Theusinger OM, Kind SL, Seifert B, Borgeat L, Gerber C, Spahn DR. Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood loss from 2008 to 2011 at the Balgrist University Hospital in Zurich, Switzerland. Blood Transfus. 2014;12(2):195–203.PubMedPubMedCentral Theusinger OM, Kind SL, Seifert B, Borgeat L, Gerber C, Spahn DR. Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood loss from 2008 to 2011 at the Balgrist University Hospital in Zurich, Switzerland. Blood Transfus. 2014;12(2):195–203.PubMedPubMedCentral
93.
Zurück zum Zitat Klein AA, Bailey CR, Charlton A, Lawson C, Nimmo AF, Payne S, et al. Association of Anaesthetists: anaesthesia and peri-operative care for Jehovah’s Witnesses and patients who refuse blood. Anaesthesia. 2019;74(1):74–82.PubMedCrossRef Klein AA, Bailey CR, Charlton A, Lawson C, Nimmo AF, Payne S, et al. Association of Anaesthetists: anaesthesia and peri-operative care for Jehovah’s Witnesses and patients who refuse blood. Anaesthesia. 2019;74(1):74–82.PubMedCrossRef
94.
Zurück zum Zitat Althoff FC, Neb H, Herrmann E, Trentino KM, Vernich L, Fullenbach C, et al. Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis. Ann Surg. 2019;269(5):794–804.PubMedCrossRef Althoff FC, Neb H, Herrmann E, Trentino KM, Vernich L, Fullenbach C, et al. Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis. Ann Surg. 2019;269(5):794–804.PubMedCrossRef
Metadaten
Titel
Preoperative Anemia Management: What’s New in 2020?
verfasst von
Daniel A. Rubinger
Christine Cahill
Andy Ngo
Marjorie Gloff
Majed A. Refaai
Publikationsdatum
08.04.2020
Verlag
Springer US
Erschienen in
Current Anesthesiology Reports / Ausgabe 2/2020
Elektronische ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-020-00385-7

Weitere Artikel der Ausgabe 2/2020

Current Anesthesiology Reports 2/2020 Zur Ausgabe

Anesthesia for Trauma (TE Grissom, Section Editor)

Regional Anesthesia in the Burn Trauma Patient

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.