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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 1/2021

11.08.2020 | Retinal Disorders

Preoperative central macular thickness as a risk factor for pseudophakic macular edema

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 1/2021

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Abstract

Purpose

This study aims to determine whether elevated central macular thickness (CMT) before uncomplicated cataract surgery may be a risk factor for developing cystic macular edema (CMEs) as measured by Cirrus-OCT and defined as the presence of macular intraretinal cysts.

Methods

A prospective study in Hospital Universitario Poniente, Almeria, Spain, where 379 patients were included for optical coherence tomography (OCT) before cataract surgery, the following day, at 1 month and at 3 months and the presence of macular intraretinal cysts assessed by OCT. Patients with known risk factors for developing CME and patients who developed major surgical complications were excluded.

Results

One hundred seventy-nine patients completed the study. The pre-surgical CMT was 257.75 (20.60) μm measured by Cirrus-OCT. After 1 month, there was an average increase in CMT of 277.86 (45.29) μm, and this increase in thickness decreased after 3 months to an average value of 267.86 (20.17) μm. There were 10.34% of patients with cysts in some of the controls after surgery. This study proposes a binary logistic model to predict the presence of CME depending on the pre-surgery CMT. The cut-off point was 260.5 μm.

Conclusion

Patients with pre-surgical macular thickness > 260.5 μm measured by Cirrus- OCT before cataract surgery, no known risk factors for developing CME and no major surgical complications presented 9.08 times more probability to develop macular intraretinal cysts after uncomplicated cataract surgery.
Literatur
1.
Zurück zum Zitat Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. Br J Ophthalmol 96(5):614–618PubMed Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. Br J Ophthalmol 96(5):614–618PubMed
2.
Zurück zum Zitat Degenring RF, Vey S, Kamppeter B, Budde WM, Jonas JB, Sauder G (2007) Effect of uncomplicated phacoemulsification on the central retina in diabetic and non-diabetic subjects. Graefes Arch Clin Exp Ophthalmol 245(1):18–23PubMed Degenring RF, Vey S, Kamppeter B, Budde WM, Jonas JB, Sauder G (2007) Effect of uncomplicated phacoemulsification on the central retina in diabetic and non-diabetic subjects. Graefes Arch Clin Exp Ophthalmol 245(1):18–23PubMed
3.
Zurück zum Zitat Grzybowski A, Sikorski BL, Ascaso FJ, Huerva V (2016) Pseudophakic cystoid macular edema: update. Clin Interv Aging 11:1221–1122PubMedPubMedCentral Grzybowski A, Sikorski BL, Ascaso FJ, Huerva V (2016) Pseudophakic cystoid macular edema: update. Clin Interv Aging 11:1221–1122PubMedPubMedCentral
4.
Zurück zum Zitat Glatz W, Steinwender G, Tarmann L, Malle EM, Schörkhuber M, Wackernagel W, Petrovski G, Wedrich A, Ivastinovic D (2017) Vitreous hyper-reflective dots in pseudophakic cystoid macular edema assessed with optical coherence tomography. PLoS One 12(12):e0189194PubMedPubMedCentral Glatz W, Steinwender G, Tarmann L, Malle EM, Schörkhuber M, Wackernagel W, Petrovski G, Wedrich A, Ivastinovic D (2017) Vitreous hyper-reflective dots in pseudophakic cystoid macular edema assessed with optical coherence tomography. PLoS One 12(12):e0189194PubMedPubMedCentral
5.
Zurück zum Zitat Fleissig E, Cohen S, Iglicki M, Goldstein M, Zur D (2018) Changes in choroidal thickness in clinically significant pseudophakic cystoid macular edema. Retina 38(8):1629–1635PubMed Fleissig E, Cohen S, Iglicki M, Goldstein M, Zur D (2018) Changes in choroidal thickness in clinically significant pseudophakic cystoid macular edema. Retina 38(8):1629–1635PubMed
6.
Zurück zum Zitat Han JV, Patel DV, Squirrell D, McGhee CN (2019) Cystoid macular oedema following cataract surgery: a review. Clin Exp Ophthalmol 47(3):346–356PubMed Han JV, Patel DV, Squirrell D, McGhee CN (2019) Cystoid macular oedema following cataract surgery: a review. Clin Exp Ophthalmol 47(3):346–356PubMed
7.
Zurück zum Zitat Lobo CL, Faria PM, Soares MA, Bernardes RC, Cunha-Vaz JG (2004) Macular alterations after small-incision cataract surgery. J Cataract Refract Surg 30(4):752–760PubMed Lobo CL, Faria PM, Soares MA, Bernardes RC, Cunha-Vaz JG (2004) Macular alterations after small-incision cataract surgery. J Cataract Refract Surg 30(4):752–760PubMed
8.
Zurück zum Zitat Vukicevic M, Gin T, Al-Qureshi S (2012) Prevalence of optical coherence tomography-diagnosed postoperative cystoid macular oedema in patients following uncomplicated phaco-emulsification cataract surgery. Clin Exp Ophthalmol 40(3):282–287PubMed Vukicevic M, Gin T, Al-Qureshi S (2012) Prevalence of optical coherence tomography-diagnosed postoperative cystoid macular oedema in patients following uncomplicated phaco-emulsification cataract surgery. Clin Exp Ophthalmol 40(3):282–287PubMed
9.
Zurück zum Zitat Danni R, Taipale C, Ilveskoski L, Tuuminen R (2019) Diabetes alone does not impair recovery from uneventful cataract surgery. Am J Ophthalmol 198:37–44PubMed Danni R, Taipale C, Ilveskoski L, Tuuminen R (2019) Diabetes alone does not impair recovery from uneventful cataract surgery. Am J Ophthalmol 198:37–44PubMed
10.
Zurück zum Zitat Biro Z, Balla Z, Kovacs B (2008) Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation. Eye (Lond) 22(1):8–12 Biro Z, Balla Z, Kovacs B (2008) Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation. Eye (Lond) 22(1):8–12
11.
Zurück zum Zitat Von Jagow B, Ohrloff C, Kohnen T (2007) Macular thickness after uneventful cataract surgery determined by optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 245(12):1765–1771 Von Jagow B, Ohrloff C, Kohnen T (2007) Macular thickness after uneventful cataract surgery determined by optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 245(12):1765–1771
12.
Zurück zum Zitat Flach AJ (1998) The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery. Trans Am Ophthalmol Soc 96:557–634PubMedPubMedCentral Flach AJ (1998) The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery. Trans Am Ophthalmol Soc 96:557–634PubMedPubMedCentral
13.
Zurück zum Zitat Sacconi R, Corbelli E, Carnevali A, Mercuri S, Rabiolo A, Querques L, Marchini G, Bandello F, Querques G (2018) Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature. Br J Ophthalmol 102(12):1684–1169PubMed Sacconi R, Corbelli E, Carnevali A, Mercuri S, Rabiolo A, Querques L, Marchini G, Bandello F, Querques G (2018) Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature. Br J Ophthalmol 102(12):1684–1169PubMed
14.
Zurück zum Zitat Yang J, Cai L, Sun Z, Ye H, Fan Q, Zhang K, Lu W, Lu Y (2017) Risk factors for and diagnosis of pseudophakic cystoid macular edema after cataract surgery in diabetic patients. J Cataract Refract Surg 43(2):207–214PubMed Yang J, Cai L, Sun Z, Ye H, Fan Q, Zhang K, Lu W, Lu Y (2017) Risk factors for and diagnosis of pseudophakic cystoid macular edema after cataract surgery in diabetic patients. J Cataract Refract Surg 43(2):207–214PubMed
15.
Zurück zum Zitat Chu CJ, Johnston RL, Buscombe C, Sallam AB, Mohamed Q, Yang YC, United Kingdom Pseudophakic Macular Edema Study Group (2016) Risk factors and incidence of macular edema after cataract surgery: a database study of 81984 eyes. Ophthalmology 123(2):316–323PubMed Chu CJ, Johnston RL, Buscombe C, Sallam AB, Mohamed Q, Yang YC, United Kingdom Pseudophakic Macular Edema Study Group (2016) Risk factors and incidence of macular edema after cataract surgery: a database study of 81984 eyes. Ophthalmology 123(2):316–323PubMed
16.
Zurück zum Zitat Liu J, Jones RE, Zhao J, Zhang J, Zhang F (2015) Influence of uncomplicated phacoemulsification on central macular thickness in diabetic patients: a meta-analysis. PLoS One 10(5):e0126343PubMedPubMedCentral Liu J, Jones RE, Zhao J, Zhang J, Zhang F (2015) Influence of uncomplicated phacoemulsification on central macular thickness in diabetic patients: a meta-analysis. PLoS One 10(5):e0126343PubMedPubMedCentral
17.
Zurück zum Zitat Henderson BA, Kim JY, Ament CS, Ferrufino-Ponce ZK, Grabowska A, Cremers SL (2007) Clinical pseudophakic cystoid macular edema. Risk factors for development and duration after treatment. J Cataract Refract Surg 33(9):1550–1558PubMed Henderson BA, Kim JY, Ament CS, Ferrufino-Ponce ZK, Grabowska A, Cremers SL (2007) Clinical pseudophakic cystoid macular edema. Risk factors for development and duration after treatment. J Cataract Refract Surg 33(9):1550–1558PubMed
18.
Zurück zum Zitat Schaub F, Adler W, Enders P, Koenig MC, Koch KR, Cursiefen C, Kirchhof B, Heindl LM (2018) Preexisting epiretinal membrane is associated with pseudophakic cystoid macular edema. Graefes Arch Clin Exp Ophthalmol 256(5):909–917PubMed Schaub F, Adler W, Enders P, Koenig MC, Koch KR, Cursiefen C, Kirchhof B, Heindl LM (2018) Preexisting epiretinal membrane is associated with pseudophakic cystoid macular edema. Graefes Arch Clin Exp Ophthalmol 256(5):909–917PubMed
19.
Zurück zum Zitat Lee KM, Lee EJ, Kim TW, Kim H (2017) Pseudophakic macular edema in primary open-angle glaucoma: a prospective study using spectral-domain optical coherence tomography. Am J Ophthalmol 179:97–109PubMed Lee KM, Lee EJ, Kim TW, Kim H (2017) Pseudophakic macular edema in primary open-angle glaucoma: a prospective study using spectral-domain optical coherence tomography. Am J Ophthalmol 179:97–109PubMed
20.
Zurück zum Zitat Wendel C, Zakrzewski H, Carleton B, Etminan M, Mikelberg FS (2018) Association of postoperative topical prostaglandin analog or beta-blocker use and incidence of pseudophakic cystoid macular edema. J Glaucoma 27(5):402–406PubMed Wendel C, Zakrzewski H, Carleton B, Etminan M, Mikelberg FS (2018) Association of postoperative topical prostaglandin analog or beta-blocker use and incidence of pseudophakic cystoid macular edema. J Glaucoma 27(5):402–406PubMed
21.
Zurück zum Zitat Razeghinejad MR (2019) The effect of latanoprost on intraocular inflammation and macular edema. Ocul Immunol Inflamm 27(2):181–188PubMed Razeghinejad MR (2019) The effect of latanoprost on intraocular inflammation and macular edema. Ocul Immunol Inflamm 27(2):181–188PubMed
22.
Zurück zum Zitat Nicholas S, Riley A, Patel H, Neveldson B, Purdie G, Wells AP (2006) Correlations between optical coherence tomography measurement of macular thickness and visual acuity after cataract extraction. Clin Exp Ophthalmol 34(2):124–129PubMed Nicholas S, Riley A, Patel H, Neveldson B, Purdie G, Wells AP (2006) Correlations between optical coherence tomography measurement of macular thickness and visual acuity after cataract extraction. Clin Exp Ophthalmol 34(2):124–129PubMed
23.
Zurück zum Zitat Perente I, Utine CA, Ozturker C, Cakir M, Kaya V, Eren H, Kapran Z, Yilmaz O (2007) Evaluation of macular changes after uncomplicated phacoemulsification surgery by optical coherence tomography. Curr Eye Res 32(3):241–247PubMed Perente I, Utine CA, Ozturker C, Cakir M, Kaya V, Eren H, Kapran Z, Yilmaz O (2007) Evaluation of macular changes after uncomplicated phacoemulsification surgery by optical coherence tomography. Curr Eye Res 32(3):241–247PubMed
24.
Zurück zum Zitat Kusbeci T, Eryigit L, Yavas G, Inan UU (2012) Evaluation of cystoid macular edema using optical coherence tomography and fundus fluorescein angiography after uncomplicated phacoemulsification surgery. Curr Eye Res 37(4):327–333PubMed Kusbeci T, Eryigit L, Yavas G, Inan UU (2012) Evaluation of cystoid macular edema using optical coherence tomography and fundus fluorescein angiography after uncomplicated phacoemulsification surgery. Curr Eye Res 37(4):327–333PubMed
25.
Zurück zum Zitat Chaudhary C, Bahadhur H, Gupta N (2015) Study of cystoid macular edema by optical coherent tomography following uneventful cataract surgery. Int Ophthalmol 35(5):685–691PubMed Chaudhary C, Bahadhur H, Gupta N (2015) Study of cystoid macular edema by optical coherent tomography following uneventful cataract surgery. Int Ophthalmol 35(5):685–691PubMed
26.
Zurück zum Zitat Yoon DH, Kang DJ, Kim MJ, Kim HK (2018) New observation of microcystic macular edema as a mild form of cystoid macular lesions after standard phacoemulsification: prevalence and risk factors. Medicine (Baltimore) 97(15):e0355 Yoon DH, Kang DJ, Kim MJ, Kim HK (2018) New observation of microcystic macular edema as a mild form of cystoid macular lesions after standard phacoemulsification: prevalence and risk factors. Medicine (Baltimore) 97(15):e0355
27.
Zurück zum Zitat Burggraaff MC, Trieu J, de Vries-Knoppert WA, Balk L, Petzold A (2014) The clinical spectrum of microcystic macular edema. Invest Ophthalmol Vis Sci 55(2):952–961PubMed Burggraaff MC, Trieu J, de Vries-Knoppert WA, Balk L, Petzold A (2014) The clinical spectrum of microcystic macular edema. Invest Ophthalmol Vis Sci 55(2):952–961PubMed
28.
Zurück zum Zitat Ylinen P, Laine I, Lindholm JM, Tuuminen (2017) Poor glycemic control as a risk factor for pseudophakic cystoid macular edema in patients with diabetes. J Cataract Refract Surg 43(11):1376–1382PubMed Ylinen P, Laine I, Lindholm JM, Tuuminen (2017) Poor glycemic control as a risk factor for pseudophakic cystoid macular edema in patients with diabetes. J Cataract Refract Surg 43(11):1376–1382PubMed
29.
Zurück zum Zitat Ching HY, Wong AC, Wong CC, Woo DC, Chan CW (2006) Cystoid macular oedema and changes in retinal thickness after phacoemulsification with optical coherence tomography. Eye (Lond) 20(3):297–303 Ching HY, Wong AC, Wong CC, Woo DC, Chan CW (2006) Cystoid macular oedema and changes in retinal thickness after phacoemulsification with optical coherence tomography. Eye (Lond) 20(3):297–303
Metadaten
Titel
Preoperative central macular thickness as a risk factor for pseudophakic macular edema
Publikationsdatum
11.08.2020
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 1/2021
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-020-04862-x

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