Background
Methods
Study population
Methods
Statistical analysis
Results
Variable | Pathological Gleason score ≥ 7 | Pathological Gleason score = 6 | p value | |
---|---|---|---|---|
Number of patients | 472 | 339 | 133 | |
age (years, median, range) | 65.4 (60.28–69) | 65.7 (61.23–69.2) | 65.2 (60.03–67.4) | 0.123 |
PSA (ng/ml, median, range) | 8.04 (5.78–11.73) | 8.98 (6.53–12.06) | 7.02 (5.03–9.21) | 0.002 |
fPSA (ng/ml, median, range) | 0.91 (0.61–1.35) | 0.82 (0.52–1.08) | 1.02 (0.87–1.41) | 0.800 |
%fPSA (ratio, median, range) | 9.29 (4.76–13.35) | 7.23 (4.22–11.8) | 11.13 (8.97–14.63) | 0.023 |
p2PSA (pg/ml, median, range) | 17 (12–26) | 19 (14–29) | 14 (10–22) | 0.058 |
%p2PSA (ratio, median, range) | 19.60 (15.33–25.79) | 20.32 (19.12–26.87) | 17.8 (13.91–21.82) | 0.007 |
PHI (median, range) | 55.68 (42.24–72.82) | 59.53 (51.11–74.61) | 45.23 (38.07–59.22) | < 0.001 |
DRE; n (%) | ||||
negative | 329 (69.7) | 227 (67.0) | 102 (76.7) | |
positive | 143 (30.3) | 112 (33.0) | 31 (23.3) | < 0.005 |
Biopsy Gleason score; n (%) | ||||
6 | 296 (62.7) | 179 (52.8) | 117 (88.0) | |
7 | 141 (29.9) | 128 (37.8) | 13 (9.8) | |
> 7 | 35 (7.4) | 32 (9.4) | 3 (2.2) | 0.032 |
Pathological tumor stage; n (%) | ||||
pT2 | 340 (72.1) | 226 (66.7) | 114 (85.7) | |
pT3 | 132 (27.9) | 113 (33.3) | 19 (14.3) | < 0.003 |
Surgical margin status; n (%) | ||||
R0 | 339 (71.8) | 230 (67.8) | 109 (82.0) | |
R1 | 133 (28.2) | 109 (32.2) | 24 (18.0) | < 0.050 |
Variables | Univariable analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
OR (95% CI) | p value | Base model OR (95% CI) | p value | Base model + PHI OR (95% CI) | p value | |
Age | 1.02 (0.99–1.06) | 0.1462 | 1.02 (0.99–1.05) | 0.1660 | 1.02 (0.99–1.06) | 0.1437 |
DRE | 1.62 (1.01–2.60) | 0.0395 | 1.71 (1.06–2.76) | 0.0261 | 1.63 (1.00–2.65) | 0.0440 |
PSA | 1.07 (1.02–1.12) | 0.0025 | 1.08 (1.03–1.14) | 0.0013 | 1.05 (0.99–1.09) | 0.0531 |
fPSA | 0.98 (0.94–1.03) | 0.4477 | 0.92 (0.82–1.02) | 0.1146 | 0.96 (0.89–1.04) | 0.2925 |
p2PSA | 1.01 (0.99–1.02) | 0.1212 | ||||
%p2PSA | 1.03 (1.01–1.06) | 0.0155 | ||||
PHI | 1.02 (1.01–1.03) | < 0.0001 | 1.02 (0197–1.03) | 0.0015 |
Variables | Univariable analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
OR (95% CI) | p value | Base model OR (95% CI) | p value | Base model + PHI OR (95% CI) | p value | |
Age | 1.02 (0.98–1.05) | 0.2943 | 1.02 (0.98–1.05) | 0.3404 | 1.02 (0.98–1.06) | 0.3068 |
DRE | 1.51 (0.87–2.59) | 0.1325 | 1.61 (0.93–2.81) | 0.0855 | 1.65 (0.94–2.89) | 0.0755 |
PSA | 1.06 (1.00–1.11) | 0.0311 | 1.07 (1.01–1.13) | 0.0150 | 1.04 (0.98–1.10) | 0.1872 |
fPSA | 0.99 (0.83–1.19) | 0.9579 | 0.88 (0.69–1.12) | 0.2901 | 0.93 (0.73–1.16) | 0.4979 |
p2PSA | 0.99 (0.99–1.01) | 0.7888 | ||||
%p2PSA | 1.03 (0.99–1.06) | 0.0666 | ||||
PHI | 1.02 (1.01–1.03) | 0.0025 | 1.02 (1.00–1.03) | 0.0153 |
Variables | Univariable analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
OR (95% CI) | p value | Base model OR (95% CI) | p value | Base model + PHI OR (95% CI) | p value | |
Age | 0.99 (0.96–1.02) | 0.6902 | 0.99 (0.96–1.03) | 0.8237 | 0.99 (0.94–1.03) | 0.8436 |
DRE | 1.64 (1.06–2.54) | 0.0233 | 1.68 (1.07–2.61) | 0.0202 | 1.59 (1.01–2.49) | 0.0404 |
Biopsy GS | 1.79 (1.07–2.98) | 0.0043 | 1.78 (1.08–2.85) | 0.0135 | 1.65 (1.02–2.38) | 0.0324 |
PSA | 1.04 (1.01–1.07) | 0.0124 | 1.04 (1.00–1.07) | 0.0323 | 1.02 (0.98–1.05) | 0.3022 |
fPSA | 1.01 (0.97–1.05) | 0.5891 | 0.99 (0.93–1.05) | 0.7388 | 1.00 (0.95–1.06) | 0.8705 |
p2PSA | 1.02 (1.01–1.03) | 0.0001 | ||||
%p2PSA | 1.02 (1.01–1.05) | 0.0243 | ||||
PHI | 1.01 (1.00–1.02) | 0.0007 | 1.01 (1.00–1.02) | 0.0112 |
Variables | Univariable analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
OR (95% CI) | p value | Base model OR (95% CI) | p value | Base model + PHI OR (95% CI) | p value | |
Age | 0.99 (0.97–1.03) | 0.9808 | 1.00 (0.97–1.03) | 0.9743 | 1.00 (0.97–1.04) | 0.9514 |
DRE | 1.44 (1.06–2.86) | 0.0067 | 1.45 (1.07–2.65) | 0.0066 | 1.43 (1.02–2.58) | 0.0121 |
Biopsy GS | 1.52 (1.04–2.88) | 0.0434 | 1.51 (1.05–2.87) | 0.0355 | 1.48 (1.05–2.36) | 0.0462 |
PSA | 1.03 (0.99–1.06) | 0.0970 | 1.02 (0.98–1.06) | 0.2120 | 0.99 (0.96–1.04) | 0.8618 |
fPSA | 0.98 (0.91–1.06) | 0.6749 | 0.97 (0.84–1.11) | 0.6051 | 0.98 (0.88–1.09) | 0.6931 |
p2PSA | 1.02 (1.01–1.03) | 0.0018 | ||||
%p2PSA | 1.03 (1.01–1.06) | 0.0036 | ||||
PHI | 1.01 (1.00–1.02) | 0.0014 | 1.01 (1.00–1.02) | 0.0066 |