Preoperative Weight Loss Program for Hepatocellular Carcinoma Patients with High Body Mass Index in Hepatectomy
- 15.10.2023
- Original Scientific Report
Erschienen in:
- Verfasst von
- Yu Saito
- Yuji Morine
- Tetsuya Ikemoto
- Shinichiro Yamada
- Hiroki Teraoku
- Sonoko Yasui-Yamada
- Maki Nishi
- Hiroshi Sakaue
- Motomu Kamada
- Tetsuya Matsuura
- Mitsuo Shimada
- Erschienen in
- World Journal of Surgery | Ausgabe 12/2023
Abstract
Background
This study aimed to investigate the usefulness of a weight-loss program (WLP) in patients with a high body mass index (BMI) prior to liver resection (Hx) for hepatocellular carcinoma (HCC).
Methods
Among 445 patients with HCC who underwent initial Hx between 2000 and 2020, 19 with a high BMI (≥25.0) were enrolled in our WLP since 2014. For calorie restriction, the amount of energy consumed was calculated as the standard body weight (SBW) kg × 20–25 kcal/day. Protein mass was calculated as SBW kg × 1.0–1.2 g/day to maintain skeletal muscle mass. Patients also performed both aerobic and resistance exercises. The before-and-after changes were compared, and the effect of WLP on the short- and long-term results was investigated.
Results
The average length of WLP was 21 days, and weight loss was successfully achieved in all patients. Body fat mass was reduced during the program, while skeletal muscle mass was maintained. WLP led to improvements in liver function and fibrotic markers, without tumor progression. There were no postoperative complications (≥Clavien–Dindo [CD] III). A retrospective comparison between with and without WLP using propensity score-matching analysis revealed that WLP group showed better NLR value, however, there were no significant differences in both short and long-term outcomes after Hx based on participation in the WLP.
Conclusions
WLP with multidisciplinary intervention improved immune-nutrition status and liver function of obese patients. WLP had not affected both short and long-term outcomes after Hx.
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- Titel
- Preoperative Weight Loss Program for Hepatocellular Carcinoma Patients with High Body Mass Index in Hepatectomy
- Verfasst von
-
Yu Saito
Yuji Morine
Tetsuya Ikemoto
Shinichiro Yamada
Hiroki Teraoku
Sonoko Yasui-Yamada
Maki Nishi
Hiroshi Sakaue
Motomu Kamada
Tetsuya Matsuura
Mitsuo Shimada
- Publikationsdatum
- 15.10.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
World Journal of Surgery / Ausgabe 12/2023
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323 - DOI
- https://doi.org/10.1007/s00268-023-07220-0
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