PrEP: Profitieren Frauen weniger?

Zurück zum Zitat Van Damme L, Corneli A, Ahmed K, Agot K, Lombaard J, Kapiga S, Malahleha M, Owino F, Manongi R, Onyango J, Temu L, Monedi MC, Mak’Oketch P, Makanda M, Reblin I, Makatu SE, Saylor L, Kiernan H, Kirkendale S, Wong C, Grant R, Kashuba A, Nanda K, Mandala J, Fransen K, Deese J, Crucitti T, Mastro TD, Taylor D; FEM-PrEP Study Group. Preexposureprophylaxis for HIV infection among African women. N Engl J Med 2012; 367:411–22.CrossRefPubMedPubMedCentral Van Damme L, Corneli A, Ahmed K, Agot K, Lombaard J, Kapiga S, Malahleha M, Owino F, Manongi R, Onyango J, Temu L, Monedi MC, Mak’Oketch P, Makanda M, Reblin I, Makatu SE, Saylor L, Kiernan H, Kirkendale S, Wong C, Grant R, Kashuba A, Nanda K, Mandala J, Fransen K, Deese J, Crucitti T, Mastro TD, Taylor D; FEM-PrEP Study Group. Preexposureprophylaxis for HIV infection among African women. N Engl J Med 2012; 367:411–22.CrossRefPubMedPubMedCentral

Zurück zum Zitat Marrazzo JM, Ramjee G, Richardson BA, Gomez K, Mgodi N, Nair G, Palanee T, Nakabiito C, van der Straten A, Noguchi L, Hendrix CW, Dai JY, Ganesh S,Mkhize B, Taljaard M, Parikh UM, Piper J, Mâsse B, Grossman C, Rooney J, Schwartz JL, Watts H, Marzinke MA, Hillier SL, McGowan IM, Chirenje ZM; VOICE Study Team. Tenofovir-based preexposure prophylaxis for HIV infection among African women. N Engl J Med. 2015; 372: 509–18.CrossRefPubMedPubMedCentral Marrazzo JM, Ramjee G, Richardson BA, Gomez K, Mgodi N, Nair G, Palanee T, Nakabiito C, van der Straten A, Noguchi L, Hendrix CW, Dai JY, Ganesh S,Mkhize B, Taljaard M, Parikh UM, Piper J, Mâsse B, Grossman C, Rooney J, Schwartz JL, Watts H, Marzinke MA, Hillier SL, McGowan IM, Chirenje ZM; VOICE Study Team. Tenofovir-based preexposure prophylaxis for HIV infection among African women. N Engl J Med. 2015; 372: 509–18.CrossRefPubMedPubMedCentral

Zurück zum Zitat Patterson KB, Prince HA, Kraft E, Jenkins AJ, Shaheen NJ, Rooney JF, Cohen MS, Kashuba AD. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med 2011;3: 112re4.CrossRefPubMedPubMedCentral Patterson KB, Prince HA, Kraft E, Jenkins AJ, Shaheen NJ, Rooney JF, Cohen MS, Kashuba AD. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med 2011;3: 112re4.CrossRefPubMedPubMedCentral

Zurück zum Zitat Hillier SL, Meyn LA, Bunge K, et al.Impact of vaginal microbiota on genital tissue and plasma concentrations of tenofovir. Presented at: CROI 2017. Seattle, WA; February 13-16, 2017. Abstract 86LB. Hillier SL, Meyn LA, Bunge K, et al.Impact of vaginal microbiota on genital tissue and plasma concentrations of tenofovir. Presented at: CROI 2017. Seattle, WA; February 13-16, 2017. Abstract 86LB.

Zurück zum Zitat Baeten JM, Palanee-Phillips T, Brown ER, Schwartz K, Soto-Torres LE, Govender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker LG, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, Pather A, Naidoo L, Husnik M, Richardson BA, Parikh UM, Mellors JW, Marzinke MA, Hendrix CW, van der Straten A, Ramjee G, Chirenje ZM, Nakabiito C, Taha TE, Jones J, Mayo A, Scheckter R, Berthiaume J, Livant E, Jacobson C, Ndase P, White R, Patterson K, Germuga D, Galaska B, Bunge K, Singh D, Szydlo DW, Montgomery ET, Mensch BS, Torjesen K, Grossman CI, Chakhtoura N, Nel A, Rosenberg Z, McGowan I, Hillier S; MTN-020-ASPIRE Study Team. Use of a Vaginal Ring ContainingDapivirine for HIV-1 Prevention in Women. N Engl J Med. 2016 Feb 22. [Epub ahead of print] Baeten JM, Palanee-Phillips T, Brown ER, Schwartz K, Soto-Torres LE, Govender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker LG, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, Pather A, Naidoo L, Husnik M, Richardson BA, Parikh UM, Mellors JW, Marzinke MA, Hendrix CW, van der Straten A, Ramjee G, Chirenje ZM, Nakabiito C, Taha TE, Jones J, Mayo A, Scheckter R, Berthiaume J, Livant E, Jacobson C, Ndase P, White R, Patterson K, Germuga D, Galaska B, Bunge K, Singh D, Szydlo DW, Montgomery ET, Mensch BS, Torjesen K, Grossman CI, Chakhtoura N, Nel A, Rosenberg Z, McGowan I, Hillier S; MTN-020-ASPIRE Study Team. Use of a Vaginal Ring ContainingDapivirine for HIV-1 Prevention in Women. N Engl J Med. 2016 Feb 22. [Epub ahead of print]

Zurück zum Zitat Annalene Nel, M.B., Ch.B., Ph.D., Neliëtte van Niekerk, M.Com., Saidi Kapiga, M.D., Sc.D., M.P.H., Linda-Gail Bekker, M.B., Ch.B., Ph.D., Cynthia Gama, M.B., Ch.B., Katherine Gill, M.B., Ch.B., Anatoli Kamali, M.B., Ch.B., Ph.D., Philip Kotze, M.B., Ch.B., M.Med., Cheryl Louw, M.B., Ch.B., Zonke Mabude, M.A., Nokuthula Miti, M.B., Ch.B., Sylvia Kusemererwa, M.B., Ch.B., M.P.H., Hugo Tempelman, M.D., Hannelie Carstens, Ph.D., Brid Devlin, Ph.D., Michelle Isaacs, B.Pharm., B.Sc., Mariëtte Malherbe, B.Sc., Winel Mans, M.B., Ch.B., Jeremy Nuttall, M.Sc., Marisa Russell, B.Sc., Smangaliso Ntshele, Dip.G.N.M., Marlie Smit, B.Diet., Leonard Solai, M.B.A., Patrick Spence, Ph.D., John Steytler, M.B., Ch.B., Kathleen Windle, B.Sc., Maarten Borremans, M.Sc., Sophie Resseler, M.Sc., Jens Van Roey, M.D., Wim Parys, M.D., Tony Vangeneugden, Ph.D., Ben Van Baelen, M.Sc., and Zeda Rosenberg, Sc.D., for the Ring Study Team Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women N Engl J Med 2016; 375:2133-2143December 1, 2016DOI: 10.1056/NEJMoa1602046 Annalene Nel, M.B., Ch.B., Ph.D., Neliëtte van Niekerk, M.Com., Saidi Kapiga, M.D., Sc.D., M.P.H., Linda-Gail Bekker, M.B., Ch.B., Ph.D., Cynthia Gama, M.B., Ch.B., Katherine Gill, M.B., Ch.B., Anatoli Kamali, M.B., Ch.B., Ph.D., Philip Kotze, M.B., Ch.B., M.Med., Cheryl Louw, M.B., Ch.B., Zonke Mabude, M.A., Nokuthula Miti, M.B., Ch.B., Sylvia Kusemererwa, M.B., Ch.B., M.P.H., Hugo Tempelman, M.D., Hannelie Carstens, Ph.D., Brid Devlin, Ph.D., Michelle Isaacs, B.Pharm., B.Sc., Mariëtte Malherbe, B.Sc., Winel Mans, M.B., Ch.B., Jeremy Nuttall, M.Sc., Marisa Russell, B.Sc., Smangaliso Ntshele, Dip.G.N.M., Marlie Smit, B.Diet., Leonard Solai, M.B.A., Patrick Spence, Ph.D., John Steytler, M.B., Ch.B., Kathleen Windle, B.Sc., Maarten Borremans, M.Sc., Sophie Resseler, M.Sc., Jens Van Roey, M.D., Wim Parys, M.D., Tony Vangeneugden, Ph.D., Ben Van Baelen, M.Sc., and Zeda Rosenberg, Sc.D., for the Ring Study Team Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women N Engl J Med 2016; 375:2133-2143December 1, 2016DOI: 10.1056/NEJMoa1602046

Zurück zum Zitat Riddler S, Balkus J, Mellors J, Parikh U, Akello C, Dadabhai S, Mhlanga F, O’Rourke C, Baeten J NNRTI-containing ART is effective for dapivirine ring breakthrough HIV-1 infection. Presented at CROI 2017. Seattle, WA; February 13-16, 2017. Abstract 952. Riddler S, Balkus J, Mellors J, Parikh U, Akello C, Dadabhai S, Mhlanga F, O’Rourke C, Baeten J NNRTI-containing ART is effective for dapivirine ring breakthrough HIV-1 infection. Presented at CROI 2017. Seattle, WA; February 13-16, 2017. Abstract 952.

Zurück zum Zitat Gulick R, Wilkin T, Chen Y, et al. HPTN 069/ACTG A5305: phase II study of maraviroc-containing regimens for HIV PrEP in United States (U.S.) women. Presented at: 21st International AIDS Conference (AIDS 2016). July 18-22, 2016. Durban, South Africa. Abstract TUAC0102. Gulick R, Wilkin T, Chen Y, et al. HPTN 069/ACTG A5305: phase II study of maraviroc-containing regimens for HIV PrEP in United States (U.S.) women. Presented at: 21st International AIDS Conference (AIDS 2016). July 18-22, 2016. Durban, South Africa. Abstract TUAC0102.