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Erschienen in: Breast Cancer Research 2/2010

01.10.2010 | Review

Present and future evolution of advanced breast cancer therapy

verfasst von: Ricardo H Álvarez

Erschienen in: Breast Cancer Research | Sonderheft 2/2010

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Abstract

Although the introduction of novel therapies and drug combinations has improved the prognosis of metastatic breast cancer, the disease remains incurable. Increased knowledge of the biology and the molecular alterations in breast cancer has facilitated the design of targeted therapies. These agents include receptor and nonreceptor tyrosine kinase inhibitors (epidermal growth factor receptor family), intracellular signaling pathways (phosphatidylinositol-3-kinase, AKT, mammalian target of rapamycin) angiogenesis inhibitors and agents that interfere with DNA repair (poly(ADP-ribose) polymerase inhibitors). In the present review, we present the most promising studies of these new targeted therapies and novel combinations of targeted therapies with cytotoxic agents.
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Metadaten
Titel
Present and future evolution of advanced breast cancer therapy
verfasst von
Ricardo H Álvarez
Publikationsdatum
01.10.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2572

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