The online version of this article (doi:10.1186/1477-7819-10-185) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interest.
RT, YY, TY, YM, KA, RT and HM treated the two patients as a team and reviewed the literature. RT drafted the manuscript, and YY, TY, YM, KA, RT and HM also helped to draft the manuscript. All authors read and approved the final manuscript.
Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.
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- Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
- BioMed Central
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