Quality of life may predict survival. In addition to clinical variables, it may be influenced by psychological factors, some of which may be accessible for intervention. The primary objective of this study was to investigate the association of intrusive thoughts and the patients’ sense of coherence with pretreatment quality of life in patients with newly diagnosed rectal cancer.
Patients were prospectively included in 16 hospitals in Sweden and Denmark. They answered an extensive questionnaire after receiving their treatment plan. Clinical data were retrieved from national quality registries for rectal cancer.
Of 1248 included patients, a total of 1085 were evaluable. Pretreatment global health-related and overall quality of life was lower in patients planned for palliative compared with curative treatment (median 53 vs. 80 on the EuroQoL visual analogue scale, p < 0.001 and odds ratio 0.56, 95% confidence interval 0.36–0.88, respectively). Quality of life was associated with intrusive thoughts (odds ratio 0.33, 95% confidence interval 0.24–0.45) and sense of coherence (odds ratio 0.44, 95% confidence interval 0.37–0.52) irrespective of the treatment plan.
Pretreatment quality of life was influenced by the intent of treatment as well as by intrusive thoughts and the patients’ sense of coherence. Interventions could modify these psychological factors, and future studies should focus on initiatives to improve quality of life for this group of patients.
Antonovsky A (1993) The structure and properties of the sense of coherence scale. Social Sci Med (1982) 36:725–733 CrossRef
Asplund D, Heath J, Gonzalez E et al (2014) Self-reported quality of life and functional outcome in patients with rectal cancer—QoLiRECT. Dan Med J 61:A4841 PubMed
Asplund D, Prytz M, Bock D et al (2015) Persistent perineal morbidity is common following abdominoperineal excision for rectal cancer. Int J Color Dis 30:1563–1570 CrossRef
Brooks R (1996) EuroQol: the current state of play. Health Policy (Amsterdam, Netherlands) 37:53–72 CrossRef
Efficace F, Innominato PF, Bjarnason G et al (2008) Validation of patient’s self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer. J Clin Oncol Off J Am Soc Clin Oncol 26:2020–2026 CrossRef
Iversen LH, Green A, Ingeholm P et al (2016) Improved survival of colorectal cancer in Denmark during 2001–2012—the efforts of several national initiatives. Acta Oncol (Stockholm, Sweden) 55(Suppl 2):10–23 CrossRef
Jim HS, Jacobsen PB (2008) Posttraumatic stress and posttraumatic growth in cancer survivorship: a review. Cancer J (Sudbury, Mass) 14:414–419 CrossRef
Kodeda K, Johansson R, Zar N et al (2015) Time trends, improvements and national auditing of rectal cancer management over an 18-year period. Color Dis: Offl J Assocf Coloproctol Great Br Irel 17:O168–O179 CrossRef
Marinez AC, Gonzalez E, Holm K et al (2016) Stoma-related symptoms in patients operated for rectal cancer with abdominoperineal excision. Int J Color Dis 31:635–641 CrossRef
Mcculllagh P, Nelder J (1989) A generalized linear models. Chapman & Hall
Mittelmark M, Sagy S, Eriksson M et al. (2016) The handbook of salutogenesis. Springer http://link.springer.com/book/10.1007/978-3-319-04600-6
Peppercorn JM, Smith TJ, Helft PR et al (2011) American society of clinical oncology statement: toward individualized care for patients with advanced cancer. J Clin Oncol Off J Am Soc Clin Oncol 29:755–760 CrossRef
Skoogh J, Ylitalo N, Larsson Omerov P et al (2010) ‘A no means no’—measuring depression using a single-item question versus Hospital Anxiety and Depression Scale (HADS-D). Ann Oncol: Off J Eur Soc Med Oncol/ESMO 21:1905–1909 CrossRef
Valentini V, Glimelius B, Haustermans K et al (2014) EURECCA consensus conference highlights about rectal cancer clinical management: the radiation oncologist’s expert review. Radiother Oncol: J Eur Soc Ther Radiol Oncol 110:195–198 CrossRef
- Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence
Marina Åkerblom Sörensson
- Springer Berlin Heidelberg
Neu im Fachgebiet Chirurgie
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