Prevalence and Detection of Sexually Transmitted Cases of Laryngeal Carcinoma
- 07.03.2020
- Original Paper
Erschienen in:
- Verfasst von
- Mohammad Abdulhameed Al-Qudah
- Ala’a Fuad Al-Shaikh
- Husam Kamel Haddad
- Mohammad Abdelatif Elhassan
- Osman Basheir Elhassan
- Melad Nabeel Dababneh
- Anas Wasef Zaitoun
- Nawwaf Saleh Al ghamdi
- Bara’a Yousef Al-Najjar
- Erschienen in
- Head and Neck Pathology | Ausgabe 4/2020
Abstract
Introduction
Human papillomavirus (HPV) is among the reported etiologies of laryngeal squamous cell carcinoma (LSCC). Understanding the impact of HPV on LSCC may help reduce its incidence. This study investigates the association between HPV and LSCC as well as the roles for different immunohistochemical stains in HPV detection.
Methods
A total of fifty-two formalin-fixed, paraffin-embedded tissue samples of LSCC, diagnosed between 2005 and 2015, were obtained from the archives of the Pathology Department. The samples were stained and processed to evaluate the relationship of HPV to LSCC.
Results
Patients had a mean age of 65.02 ± 14.341 years. By polymerase chain reaction (PCR), high-risk strains of HPV were detected in 15.4% of tissue samples. HPV-16 was found in 75% of the positive samples for an overall prevalence of 13.5%. P16 immunostaining was positive in 15.4% of cases while cyclin B and cyclin E were positive in 65.4% and 76.9%, respectively. Over half of the cases were histologically graded as moderately-differentiated, 28.8% as well-differentiated, and 15.4% as poorly-differentiated.
Discussion
The prevalence of HPV-positive LSCC was lower than previously stated in the literature. HPV-16 was the most commonly detected subtype, in concordance with the findings of multiple other studies. HPV-positive LSCC trended with higher histologic grade. P16 and cyclin E immunohistochemical stains were of limited use in identifying HPV in LSCC. In contrast, cyclin B had a high sensitivity which could be used to rule out HPV in LSCC.
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- Titel
- Prevalence and Detection of Sexually Transmitted Cases of Laryngeal Carcinoma
- Verfasst von
-
Mohammad Abdulhameed Al-Qudah
Ala’a Fuad Al-Shaikh
Husam Kamel Haddad
Mohammad Abdelatif Elhassan
Osman Basheir Elhassan
Melad Nabeel Dababneh
Anas Wasef Zaitoun
Nawwaf Saleh Al ghamdi
Bara’a Yousef Al-Najjar
- Publikationsdatum
- 07.03.2020
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 4/2020
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-020-01150-2
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