Introduction
Methods
Data source
Ethics statement
HPV genotyping
Statistical analysis
Results
Characteristics of the study participants
HPV subtype | Positive, n(%) | Single-type infection, n(%) | Multiple-type infection, n (%) |
---|---|---|---|
HPV52 | 2130 (3.58) | 1226 (2.06) | 904 (1.52) |
HPV16 | 1695 (2.85) | 1008 (1.69) | 687 (1.15) |
HPV58 | 1571 (2.64) | 822 (1.38) | 749 (1.26) |
HPV81 | 1155 (1.94) | 603 (1.01) | 552 (0.93) |
HPV53 | 1080 (1.81) | 551 (0.93) | 529 (0.89) |
HPV39 | 871 (1.46) | 448 (0.75) | 423 (0.71) |
HPV51 | 863 (1.45) | 448 (0.75) | 415 (0.7) |
HPV33 | 762 (1.28) | 333 (0.56) | 429 (0.72) |
HPV6 | 636 (1.07) | 293 (0.49) | 343 (0.58) |
HPV18 | 603 (1.01) | 302 (0.51) | 301 (0.51) |
HPV68 | 590 (0.99) | 305 (0.51) | 285 (0.48) |
HPV31 | 575 (0.97) | 275 (0.46) | 300 (0.5) |
HPV11 | 542 (0.91) | 249 (0.42) | 293 (0.49) |
HPV66 | 494 (0.83) | 220 (0.37) | 274 (0.46) |
HPV56 | 340 (0.57) | 161 (0.27) | 179 (0.3) |
HPV59 | 238 (0.4) | 99 (0.17) | 139 (0.23) |
HPV44 | 207 (0.35) | 107 (0.18) | 100 (0.17) |
HPV35 | 173 (0.29) | 80 (0.13) | 93 (0.16) |
HPV45 | 173 (0.29) | 85 (0.14) | 88 (0.15) |
HPV42 | 137 (0.23) | 76 (0.13) | 61 (0.1) |
HPV43 | 66 (0.11) | 26 (0.04) | 40 (0.07) |
Trends of different HPV subtype infection rates
HPV subtype | 2011,n(%) | 2012,n(%) | 2013,n(%) | 2014,n(%) | 2015,n(%) | 2016,n(%) | 2017,n(%) | 2018,n(%) | 2019,n(%) | P value for trend |
---|---|---|---|---|---|---|---|---|---|---|
HPV16 | 58 (17.52) | 107 (13.21) | 181 (14.62) | 216 (10.34) | 240 (10.95) | 251 (10.87) | 378 (10.99) | 263 (10.59) | 1 (11.11) | 0.002 |
HPV52 | 57 (17.22) | 118 (14.57) | 178 (14.38) | 296 (14.18) | 317 (14.46) | 286 (12.38) | 482 (14.01) | 393 (15.83) | 3 (33.33) | 0.0029 |
HPV58 | 29 (8.76) | 110 (13.58) | 114 (9.21) | 228 (10.92) | 202 (9.22) | 258 (11.17) | 343 (9.97) | 286 (11.52) | 1 (11.11) | 0.003 |
HPV81 | 23 (6.95) | 58 (7.16) | 97 (7.84) | 177 (8.48) | 203 (9.26) | 225 (9.74) | 234 (6.8) | 137 (5.52) | 1 (11.11) | 0.0033 |
HPV53 | 21 (6.34) | 58 (7.16) | 75 (6.06) | 139 (6.66) | 164 (7.48) | 181 (7.84) | 243 (7.06) | 199 (8.01) | 0 (0) | 0.0012 |
HPV11 | 21 (6.34) | 39 (4.81) | 64 (5.17) | 77 (3.69) | 82 (3.74) | 67 (2.9) | 112 (3.26) | 80 (3.22) | 0 (0) | 0.0037 |
HPV18 | 19 (5.74) | 40 (4.94) | 54 (4.36) | 79 (3.78) | 96 (4.38) | 77 (3.33) | 133 (3.87) | 105 (4.23) | 0 (0) | 0.0022 |
HPV6 | 17 (5.14) | 44 (5.43) | 52 (4.2) | 105 (5.03) | 105 (4.79) | 104 (4.5) | 118 (3.43) | 91 (3.66) | 0 (0) | 0.002 |
HPV31 | 15 (4.53) | 38 (4.69) | 68 (5.49) | 101 (4.84) | 72 (3.28) | 93 (4.03) | 122 (3.55) | 66 (2.66) | 0 (0) | 0.0022 |
HPV33 | 15 (4.53) | 68 (8.4) | 67 (5.41) | 139 (6.66) | 108 (4.93) | 117 (5.06) | 148 (4.3) | 100 (4.03) | 0 (0) | 0.0019 |
HPV66 | 13 (3.93) | 18 (2.22) | 37 (2.99) | 54 (2.59) | 76 (3.47) | 82 (3.55) | 118 (3.43) | 96 (3.87) | 0 (0) | 0.0047 |
HPV68 | 12 (3.63) | 26 (3.21) | 70 (5.65) | 89 (4.26) | 77 (3.51) | 81 (3.51) | 133 (3.87) | 102 (4.11) | 0 (0) | 0.0031 |
HPV39 | 7 (2.11) | 26 (3.21) | 41 (3.31) | 112 (5.36) | 151 (6.89) | 166 (7.19) | 212 (6.16) | 156 (6.28) | 0 (0) | 0.0076 |
HPV45 | 5 (1.51) | 7 (0.86) | 20 (1.62) | 29 (1.39) | 17 (0.78) | 30 (1.3) | 43 (1.25) | 20 (0.81) | 2 (22.22) | 0.0033 |
HPV56 | 5 (1.51) | 20 (2.47) | 36 (2.91) | 41 (1.96) | 44 (2.01) | 37 (1.6) | 98 (2.85) | 59 (2.38) | 0 (0) | 0.0056 |
HPV51 | 4 (1.21) | 7 (0.86) | 18 (1.45) | 105 (5.03) | 155 (7.07) | 151 (6.54) | 257 (7.47) | 166 (6.69) | 0 (0) | 0.016 |
HPV59 | 4 (1.21) | 10 (1.23) | 24 (1.94) | 31 (1.48) | 33 (1.51) | 38 (1.65) | 53 (1.54) | 45 (1.81) | 0 (0) | 0.0032 |
HPV35 | 3 (0.91) | 11 (1.36) | 12 (0.97) | 31 (1.48) | 20 (0.91) | 20 (0.87) | 44 (1.28) | 32 (1.29) | 0 (0) | 0.0047 |
HPV44 | 2 (0.6) | 2 (0.25) | 14 (1.13) | 26 (1.25) | 19 (0.87) | 28 (1.21) | 69 (2.01) | 47 (1.89) | 0 (0) | 0.0182 |
HPV42 | 1 (0.3) | 2 (0.25) | 14 (1.13) | 9 (0.43) | 10 (0.46) | 10 (0.43) | 62 (1.8) | 29 (1.17) | 0 (0) | 0.0488 |
HPV43 | 0 (0) | 1 (0.12) | 2 (0.16) | 4 (0.19) | 1 (0.05) | 8 (0.35) | 38 (1.1) | 11 (0.44) | 1 (11.11) | 0.0868 |
Total | 331 | 810 | 1238 | 2088 | 2192 | 2310 | 3440 | 2483 | 9 |
Trends of single-type and multiple-type HPV infection rates
Number (HPV subtype) | Infection | Infection Rate(%) |
---|---|---|
1 HPV subtype | 7717 | 72.32 |
2 HPV subtypes | 2065 | 19.35 |
3 HPV subtypes | 610 | 5.72 |
4 HPV subtypes | 203 | 1.9 |
5 HPV subtypes | 51 | 0.48 |
6 HPV subtypes | 13 | 0.12 |
7 HPV subtypes | 9 | 0.08 |
8 HPV subtypes | 1 | 0.01 |
9 HPV subtypes | 1 | 0.01 |
Number of (HPV infection subtypes) | 2011,n(%) | 2012,n(%) | 2013,n(%) | 2014,n(%) | 2015,n(%) | 2016,n(%) | 2017,n(%) | 2018,n(%) | 2019,n(%) | P value for trend |
---|---|---|---|---|---|---|---|---|---|---|
1 HPV subtypes | 160 (69.87) | 417 (71.28) | 600 (70.18) | 1040 (70.51) | 1119 (71.78) | 1235 (73.91) | 1737 (71.48) | 1400 (75.39) | 9 (100) | 0.0034 |
2 HPV subtypes | 46 (20.09) | 128 (21.88) | 173 (20.23) | 309 (20.95) | 312 (20.01) | 291 (17.41) | 478 (19.67) | 328 (17.66) | 0 (0) | 0.0029 |
3 HPV subtypes | 14 (6.11) | 29 (4.96) | 53 (6.2) | 92 (6.24) | 82 (5.26) | 96 (5.75) | 146 (6.01) | 98 (5.28) | 0 (0) | 0.0036 |
4 HPV subtypes | 8 (3.49) | 6 (1.03) | 19 (2.22) | 22 (1.49) | 32 (2.05) | 42 (2.51) | 50 (2.06) | 24 (1.29) | 0 (0) | 0.0048 |
5 HPV subtypes | 0 (0) | 4 (0.68) | 6 (0.7) | 8 (0.54) | 11 (0.71) | 6 (0.36) | 10 (0.41) | 6 (0.32) | 0 (0) | 0.0033 |
6 HPV subtypes | 1 (0.44) | 1 (0.17) | 2 (0.23) | 2 (0.14) | 1 (0.06) | 0 (0) | 6 (0.25) | 0 (0) | 0 (0) | 0.0512 |
7 HPV subtypes | 0 (0) | 0 (0) | 1 (0.12) | 2 (0.14) | 2 (0.13) | 1 (0.06) | 2 (0.08) | 1 (0.05) | 0 (0) | 0.01 |
8 HPV subtypes | 0 (0) | 0 (0) | 1 (0.12) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0.3434 |
9 HPV subtypes | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (0.04) | 0 (0) | 0 (0) | 0.3434 |
Total | 462 | 1214 | 1794 | 2976 | 3218 | 3450 | 4928 | 3796 | 19 | 0 |
Trend analysis stratified by 5-year age groups from 2011 to 2019
Age (years) | 2011,n(%) | 2012,n(%) | 2013,n(%) | 2014,n(%) | 2015,n(%) | 2016,n(%) | 2017,n(%) | 2018,n(%) | 2019,n(%) | P value for trend |
---|---|---|---|---|---|---|---|---|---|---|
< 20 | 5 (1.08) | 9 (0.74) | 14 (0.78) | 17 (0.57) | 28 (0.87) | 32 (0.93) | 41 (0.83) | 31 (0.82) | 0 (0) | 0.0029 |
20–24 | 31 (6.71) | 64 (5.27) | 96 (5.35) | 156 (5.24) | 174 (5.41) | 192 (5.57) | 278 (5.64) | 249 (6.56) | 2 (11.11) | 0.0026 |
25–29 | 51 (11.04) | 93 (7.66) | 151 (8.42) | 268 (9.01) | 301 (9.35) | 352 (10.2) | 546 (11.08) | 384 (10.12) | 1 (5.56) | 0.0039 |
30–34 | 34 (7.36) | 101 (8.32) | 145 (8.08) | 201 (6.75) | 285 (8.86) | 313 (9.07) | 422 (8.56) | 329 (8.67) | 2 (11.11) | 0.0028 |
35–39 | 28 (6.06) | 69 (5.68) | 116 (6.47) | 176 (5.91) | 189 (5.87) | 198 (5.74) | 320 (6.49) | 211 (5.56) | 1 (5.56) | 0.0026 |
40–44 | 28 (6.06) | 78 (6.43) | 112 (6.24) | 165 (5.54) | 184 (5.72) | 183 (5.3) | 245 (4.97) | 171 (4.5) | 1 (5.56) | 0.0013 |
45–49 | 26 (5.63) | 69 (5.68) | 92 (5.13) | 157 (5.28) | 141 (4.38) | 143 (4.14) | 215 (4.36) | 169 (4.45) | 0 (0) | 0.0014 |
50–54+ | 16 (3.46) | 52 (4.28) | 76 (4.24) | 138 (4.64) | 136 (4.23) | 132 (3.83) | 187 (3.79) | 126 (3.32) | 1 (5.56) | 0.0018 |
55–59 | 9 (1.95) | 34 (2.8) | 47 (2.62) | 85 (2.86) | 88 (2.73) | 91 (2.64) | 95 (1.93) | 105 (2.77) | 1 (5.56) | 0.0016 |
60–64 | 2 (0.43) | 28 (2.31) | 27 (1.51) | 79 (2.65) | 52 (1.62) | 59 (1.71) | 66 (1.34) | 67 (1.77) | 0 (0) | 0.0024 |
65–69 | 1 (0.22) | 6 (0.49) | 13 (0.72) | 33 (1.11) | 22 (0.68) | 23 (0.67) | 38 (0.77) | 35 (0.92) | 0 (0) | 0.0047 |
70–74 | 0 (0) | 2 (0.16) | 6 (0.33) | 9 (0.3) | 5 (0.16) | 6 (0.17) | 6 (0.12) | 16 (0.42) | 0 (0) | 0.0099 |
75–79 | 0 (0) | 1 (0.08) | 2 (0.11) | 4 (0.13) | 4 (0.12) | 1 (0.03) | 3 (0.06) | 4 (0.11) | 0 (0) | 0.0057 |
80–84 | 0 (0) | 1 (0.08) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (0.02) | 1 (0.03) | 0 (0) | 0.0805 |
≥85 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (0.02) | 0 (0) | 0 (0) | 0.3466 |
Total | 462 | 1214 | 1794 | 2976 | 3218 | 3450 | 4928 | 3796 | 18 | 0 |