Anemia is the most common hematological abnormality in Human immunodeficiency virus (HIV) positive patients and a significant predictor of its progression to AIDS or death. This study was aimed to assess the prevalence of anemia before and after initiation of antiretroviral therapy (ART) among HIV positive patients attending Black Lion Specialized Hospital, Addis Ababa, Ethiopia.
A cross sectional study was conducted from January to April, 2017 in Black Lion Specialized Hospital, Addis Ababa, Ethiopia. A total of 255 patients on ART were selected using simple random sampling techniques. Socio-demographic and clinical characteristics of the study subjects were collected using structured questionnaire. Measurements of complete blood cell counts and CD4 + T cell counts were made using Sysmex XT 2000i hematology analyzer and BD FACS Count CD4 analyzer, respectively. Statistical analysis of the data (Chi-square, paired T-test, logistic regression) was done using SPSS version 20. A p-value < 0.05 was considered as significant.
Prevalence of anemia before and after ART initiation was 41.9 and 11.4% respectively. There are a significance differences in CD4 + T cell count, RBC count, hemoglobin values and RBC indices in HIV patients before and after ART initiation (p-value < 0.05). WHO clinical stages and CD4+ T cell counts were found to be associated with the prevalence of anemia before ART initiation. Among the total number of anemic cases, normocytic normochromic anemia was present in 71% of the cases before ART and in 58.6% of the cases after ART. The prevalence of macrocytic normochromic anemia before and after ART initiation was 4.7 and 27.6% respectively.
It is evident from this study that there is a remarkable reduction in the prevalence of anemia after ART initiation. However, a significant proportion of HIV patients remained anemic after 6 months of ART initiation suggesting the need for routine screening and proper treatment of anemia to mitigate its adverse effects.
Erhabor O, Ejele OA, Nwauche CA, Buseri FI. Some haematological parameters in human immunodeficiency virus (HIV) infected Africans: the Nigerian perspective. Niger J Med. 2005;14(1):33–8. PubMed
Alamdo AG, Fiseha T, Tesfay A, Deber MK, Tirfe ZM, Tilahun T. Anemia and its associated risk factors at the time of antiretroviral therapy initiation in public health facilities of Arba Minch town, Southern Ethiopia. Health. 2015;7(12):1657–64. CrossRef
Volberding P. The impact of anemia on quality of life in human immunodeficiency virus–infected patients. J Infect Dis. 2002;185:110–4. CrossRef
Moyle G. Anemia in persons with HIV infection: prognostic marker and contributor to morbidity. AIDS Rev. 2002;4(1):13–20. PubMed
WHO. Hemoglobin concentrations for the diagnosis of anemia and assessment of severity. Vitamin and mineral nutrition information system. Geneva: World Health Organization; 2011.
Daka D, Lelissa D, Amsalu A. Prevalence of anemia before and after the initiation of antiretroviral therapy at ART center of Hawassa University Referral Hospital, Hawassa, South Ethiopia. Sch J Med. 2013;3(1):1–6.
Denu BA, Kida IM, Hammagabdo A, Dayar A, Sahabi MA. Prevalence of anemia and immunological markers in HIV-infected patients on highly active antiretroviral therapy in Northeastern Nigeria. Infect Dis. 2013;6:25–33.
Omoregie R, Omokaro EU, Palmer O, Ogefere HO, Egbeobauwaye A, Adeghe JE, Osakue SI, Ihemeje V. Prevalence of anaemia among HIV-infected patients in Benin City, Nigeria. Tanzan J of Health Res. 2009;11(1):1–4. CrossRef
Adane A, Desta K, Bezabih A, Gashaye A, Kassa D. HIV-associated anemia before and after initiation of antiretroviral therapy at ART Centre of Minilik II Hospital, Addis Ababa, Ethiopia. Ethiop Med J. 2012;50(1):13–21. PubMed
Tesfaye Z, Enawgaw B. Prevalence of anemia before and after initiation of highly active antiretroviral therapy among HIV positive patients in Northwest Ethiopia: a retrospective study. BMC Res Notes. 2014;7(1):1–5. CrossRef
Enawgaw B, Alem M, Addis Z, Melku M. Determination of hematological and immunological parameters among HIV positive patients taking HAART and treatment naïve in the antiretroviral therapy clinic of Gondar University Hospital, Gondar, Northwest Ethiopia: a comparative cross-sectional study. BMC Hematol. 2014;14:8. CrossRefPubMedPubMedCentral
Owiredu WK, Quaye L, Amidu N, Addai-Mensah O. Prevalence of anemia and immunological markers among Ghanaian HAART-naive HIV-patients and those on HAART. Afri Health Sci. 2011;11(1):2–15.
- Prevalence of anemia before and after initiation of antiretroviral therapy among HIV infected patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a cross sectional study
Gashaw Garedew Woldeamanuel
Diresibachew Haile Wondimu
- BioMed Central
Neu im Fachgebiet Onkologie
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