Skip to main content
Erschienen in: Indian Journal of Gastroenterology 3/2018

13.06.2018 | Original Article

Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet

verfasst von: Ashish Joshi, Sushil Falodia, Naveen Kumar, Pawan Gupta, P. C. Khatri

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

Liver involvement in celiac disease (CD) is classified into autoimmune and cryptogenic. The association between CD and autoimmune liver diseases like autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis is well-established; however, the data on patients with cryptogenic cirrhosis, particularly from India, are scanty. So we did this study to find the prevalence of CD in patients with cryptogenic cirrhosis.

Methods

This was a prospective observational study, involving children of less than 18 years old attending Pediatric and Gastroenterology clinic with a diagnosis of cryptogenic cirrhosis. The patients were evaluated for CD and divided into two groups: chronic liver disease (CLD) with CD, and CLD without CD. Both the groups were followed up for 6 months. CLD with CD group was treated with gluten-free-diet (GFD) and CLD without CD group was followed up without any specific intervention except standard care of CLD.

Results

Out of 84 patients, 11 (13.1%) were diagnosed as CLD with CD. There was an improvement in hemoglobin levels, liver function tests, and Child-Pugh score after initiation of GFD in CLD with CD group.

Conclusion

The prevalence of CD in cryptogenic cirrhosis was 13.1%. Screening for CD is recommended for cryptogenic cirrhosis. Hepatic functions improve with a GFD in CD patients with cirrhosis.
Literatur
2.
Zurück zum Zitat Makharia GK, Verma AK, Amarchand R, et al. Prevalence of celiac disease in the northern part of India: a community based study. J Gastroenterol Hepatol. 2011;26:894–900.CrossRefPubMed Makharia GK, Verma AK, Amarchand R, et al. Prevalence of celiac disease in the northern part of India: a community based study. J Gastroenterol Hepatol. 2011;26:894–900.CrossRefPubMed
3.
Zurück zum Zitat Sood A, Midha V, Sood N, et al. Prevalence of celiac disease among school going children in Punjab, North India. J Gastroenterol Hepatol. 2006;21:1622–5.CrossRefPubMed Sood A, Midha V, Sood N, et al. Prevalence of celiac disease among school going children in Punjab, North India. J Gastroenterol Hepatol. 2006;21:1622–5.CrossRefPubMed
4.
Zurück zum Zitat Hu WT, Murray JA, Greenway MC, et al. Cognitive impairment and celiac disease. Arch Neurol. 2006;63:1440–6.CrossRefPubMed Hu WT, Murray JA, Greenway MC, et al. Cognitive impairment and celiac disease. Arch Neurol. 2006;63:1440–6.CrossRefPubMed
5.
6.
Zurück zum Zitat Frustaci A, Cuoco L, Chimenti C, et al. Celiac disease associated with autoimmune myocarditis. Circulation. 2002;105:2611–8.CrossRefPubMed Frustaci A, Cuoco L, Chimenti C, et al. Celiac disease associated with autoimmune myocarditis. Circulation. 2002;105:2611–8.CrossRefPubMed
7.
Zurück zum Zitat Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology. 2006;131:1981–2002.CrossRefPubMed Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology. 2006;131:1981–2002.CrossRefPubMed
8.
Zurück zum Zitat Maggiore G, Caprai S. Liver involvement in celiac disease. Indian J Pediatr. 2006;73:809–11.CrossRefPubMed Maggiore G, Caprai S. Liver involvement in celiac disease. Indian J Pediatr. 2006;73:809–11.CrossRefPubMed
9.
Zurück zum Zitat De Franceschi L, Volta U, Molinaro N, et al. Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci. 1998;43:2190–5.CrossRefPubMed De Franceschi L, Volta U, Molinaro N, et al. Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci. 1998;43:2190–5.CrossRefPubMed
10.
Zurück zum Zitat Mounajjed T, Oxentenko A, Shmidt E, et al. The liver in celiac disease: clinical manifestations, histologic features, and response to gluten-free diet in 30 patients. Am J Clin Pathol. 2011;136:128–37.CrossRefPubMed Mounajjed T, Oxentenko A, Shmidt E, et al. The liver in celiac disease: clinical manifestations, histologic features, and response to gluten-free diet in 30 patients. Am J Clin Pathol. 2011;136:128–37.CrossRefPubMed
11.
Zurück zum Zitat Philips AC, Sahney A. Oesophageal and gastric varices: historical aspects, classification and grading: everything in one place. Gastroenterol Rep (Oxf). 2016;4:186–95. Philips AC, Sahney A. Oesophageal and gastric varices: historical aspects, classification and grading: everything in one place. Gastroenterol Rep (Oxf). 2016;4:186–95.
12.
13.
Zurück zum Zitat Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for celiac disease and related terms. Gut. 2013;62:43–52.CrossRefPubMed Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for celiac disease and related terms. Gut. 2013;62:43–52.CrossRefPubMed
14.
Zurück zum Zitat Ghany MG, Hoofnagle JH. Approach to the patient with liver disease. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, Eds. Harrison’s Principles of Internal Medicine. 19th ed. New York: Mc Graw Hill;2015:1989–95. Ghany MG, Hoofnagle JH. Approach to the patient with liver disease. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, Eds. Harrison’s Principles of Internal Medicine. 19th ed. New York: Mc Graw Hill;2015:1989–95.
15.
Zurück zum Zitat Maiwall R, Goel A, Pulimood AB, et al. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014;33:517–23.CrossRefPubMed Maiwall R, Goel A, Pulimood AB, et al. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014;33:517–23.CrossRefPubMed
16.
Zurück zum Zitat Lindgren S, Sjoberg K, Eriksson S. Unsuspected celiac disease in chronic cryptogenic liver disease. Scand J Gastroenterol. 1994;29:661–4.CrossRefPubMed Lindgren S, Sjoberg K, Eriksson S. Unsuspected celiac disease in chronic cryptogenic liver disease. Scand J Gastroenterol. 1994;29:661–4.CrossRefPubMed
17.
Zurück zum Zitat Stevens FM, McLoughlin RM. Celiac disease is potentially treatable cause of liver failure. Eur J Gastroenterol Hepatol. 2005;17:1015–7.CrossRefPubMed Stevens FM, McLoughlin RM. Celiac disease is potentially treatable cause of liver failure. Eur J Gastroenterol Hepatol. 2005;17:1015–7.CrossRefPubMed
18.
Zurück zum Zitat Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology. 2002;122:881–8.CrossRefPubMed Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology. 2002;122:881–8.CrossRefPubMed
19.
Zurück zum Zitat Korponay-Szabó IR, Halttunen T, Szalai Z, et al. In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut. 2004;53:641–8.CrossRefPubMedPubMedCentral Korponay-Szabó IR, Halttunen T, Szalai Z, et al. In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut. 2004;53:641–8.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Bardella MT, Vecchi M, Conte D, et al. Chronic unexplained hypertransaminasemia may be caused by occult celiac disease. Hepatology. 1999;29:654–7.CrossRefPubMed Bardella MT, Vecchi M, Conte D, et al. Chronic unexplained hypertransaminasemia may be caused by occult celiac disease. Hepatology. 1999;29:654–7.CrossRefPubMed
22.
Zurück zum Zitat Bonamico M, Pitzalis G, Culasso F, et al. Hepatic damage during celiac disease in childhood. Minerva Pediatr. 1986;38:959–63.PubMed Bonamico M, Pitzalis G, Culasso F, et al. Hepatic damage during celiac disease in childhood. Minerva Pediatr. 1986;38:959–63.PubMed
23.
Zurück zum Zitat Volta U, De Franceschi L, Lari F, et al. Celiac disease hidden by cryptogenic hypertransaminasemia. Lancet. 1998;352:26–9.CrossRefPubMed Volta U, De Franceschi L, Lari F, et al. Celiac disease hidden by cryptogenic hypertransaminasemia. Lancet. 1998;352:26–9.CrossRefPubMed
24.
Zurück zum Zitat Ozkan M, Trandafir L, Bozomitu L, et al. Liver involvement in celiac disease in children. Rev Med Chir Soc Med Nat Iasi. 2011;115:1030–4.PubMed Ozkan M, Trandafir L, Bozomitu L, et al. Liver involvement in celiac disease in children. Rev Med Chir Soc Med Nat Iasi. 2011;115:1030–4.PubMed
25.
Zurück zum Zitat Singh P, Agnihotri A, Jindal G, et al. Celiac disease and chronic liver disease: is there a relationship? Indian J Gastroenterol. 2013;32:404–8.CrossRefPubMed Singh P, Agnihotri A, Jindal G, et al. Celiac disease and chronic liver disease: is there a relationship? Indian J Gastroenterol. 2013;32:404–8.CrossRefPubMed
26.
Zurück zum Zitat Das P, Makharia GK. Gut-liver axis and disease infidelity: a subject worth exploring. Indian J Gastroenterol. 2014;33:503–6.CrossRefPubMed Das P, Makharia GK. Gut-liver axis and disease infidelity: a subject worth exploring. Indian J Gastroenterol. 2014;33:503–6.CrossRefPubMed
27.
Zurück zum Zitat Yasutake K, Kohjima M, Nakashima M, Kotoh K, Nakamuta M, Enjoji M. Nutrition therapy for liver diseases based on the status of nutritional intake. Gastroenterol Res Pract. 2012;2012:85WE9697.CrossRef Yasutake K, Kohjima M, Nakashima M, Kotoh K, Nakamuta M, Enjoji M. Nutrition therapy for liver diseases based on the status of nutritional intake. Gastroenterol Res Pract. 2012;2012:85WE9697.CrossRef
Metadaten
Titel
Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet
verfasst von
Ashish Joshi
Sushil Falodia
Naveen Kumar
Pawan Gupta
P. C. Khatri
Publikationsdatum
13.06.2018
Verlag
Springer India
Erschienen in
Indian Journal of Gastroenterology / Ausgabe 3/2018
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-018-0857-6

Weitere Artikel der Ausgabe 3/2018

Indian Journal of Gastroenterology 3/2018 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.