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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Thyroid Research 1/2014

Prevalence of diabetes mellitus in patients with newly evaluated papillary thyroid cancer

Zeitschrift:
Thyroid Research > Ausgabe 1/2014
Autoren:
Yannis M Paulus, Elyn R Riedel, Mona M Sabra, Robert Michael Tuttle, Marcia F Kalin
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contribution

YMP, MFK, and RMT designed the initial study and prepared the final version of the manuscript. MFK supervised the conduction of the study. RMT provided the patient database. YMP reviewed the patient charts, acquired the patient data, and prepared the draft of the manuscript. ERR performed the statistical analysis and MMS assisted with analysis and interpretation of the data revised the manuscript. All of the authors critically revised, read, and approved the final manuscript for submission and agree to be accountable for all aspects relating to the accuracy and integrity of the work.

Abstract

Background

This study investigates whether diabetes mellitus is a risk factor for the development of papillary thyroid cancer, using an age-, gender-, and race-matched analysis.

Methods

We retrospectively reviewed the charts of 1559 patients with newly evaluated thyroid cancer over a 4-year period at our institution and identified 1313 patients (84%) with papillary thyroid carcinoma. Characteristics of patients with diabetes versus those without diabetes were compared with a chi-square test for categorical variables and the Wilcoxon Rank Sum test for numeric variables. The prevalence of diabetes among patients with papillary thyroid carcinoma at our institution was compared (using an age-, gender-, and race-matched analysis) with that expected based on data from the continuous National Health and Nutrition Examination Survey (NHANES) from the same time period.

Results

For patients with papillary thyroid carcinoma, the median age was 47 years; 74% were female; 83% were white; and the prevalence of diabetes was 8%. Among those with diabetes, 92% had type 2 diabetes, and 24% were treated with insulin. Risk factors for diabetes included age and race. The prevalence of diabetes among patients with papillary thyroid carcinoma of all ages versus that among patients from NHANES of all ages was not significantly different (RR 1.07, CI 0.88 - 1.28). The prevalence of diabetes among patients with papillary thyroid cancer who were 44 years of age or younger versus that among patients from NHANES who were 44 years of age or younger, however, was significantly increased (RR 2.32, CI 1.37 - 3.66). There was no significant difference when subgroup analysis was performed by gender or race.

Conclusions

We found an increased prevalence of diabetes in patients with papillary thyroid carcinoma who were 44 years of age or younger.
Literatur
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