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European Archives of Oto-Rhino-Laryngology

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24.06.2016 | Head and Neck

Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

verfasst von: Tania Rodríguez-Santamarta, Juan Pablo Rodrigo, Juana M. García-Pedrero, Saúl Álvarez-Teijeiro, M. Ángeles Villaronga, Laura Suárez-Fernández, Marta E. Alvarez-Argüelles, Aurora Astudillo, Juan Carlos de Vicente

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 12/2016

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Abstract

The aim of this study was to analyze the prevalence of high-risk HPV in oral squamous cell carcinoma (OSCC) in a northern Spanish population, as well as to ascertain the prognostic role of p16^INK4a expression. The examination samples were collected from paraffin tissue blocks, from 125 patients surgically treated between 1996 and 2007. All cases were histologically evaluated, and the presence of HPV was assessed by p16 and p53immunohistochemistry followed by DNA detection by in situ hybridization (ISH) and polymerase chain reaction (PCR) amplification using the combination of consensus primers MY11/GP6 + . Fourteen cases (11 %) were p16-immunopositive, and p53 was scored positive in 73 cases (58 %). Five cases (4 %) showed a simultaneous p16-positive and p53-negative immunostaining. ISH was negative in all the cases. Among the p16INK4a-immunopositive cases, PCR amplification failed to reveal HPV DNA in any tumor samples. There were no statistically significant differences in any clinical or pathological characteristics of the patients regarding p16^INK4a expression. T classification, neck-node metastasis, and clinical stage showed outcome relevance. However, no significant differences in cause-specific survival based on p16INK4a were observed. We did not find any high-risk HPV types in our patients, thus, are unlikely that HPV has an important role in the etiology of OSCC. p16INK4a protein was neither an accurate marker of HPV infection nor a prognosis marker in OSCC.

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Titel: Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain
verfasst von: Tania Rodríguez-Santamarta
Juan Pablo Rodrigo
Juana M. García-Pedrero
Saúl Álvarez-Teijeiro
M. Ángeles Villaronga
Laura Suárez-Fernández
Marta E. Alvarez-Argüelles
Aurora Astudillo
Juan Carlos de Vicente
Publikationsdatum: 24.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 12/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4152-9

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Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

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