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Erschienen in: Journal of Clinical Immunology 6/2020

27.06.2020 | Original Article

Prevalence of Immunological Defects in a Cohort of 97 Rubinstein–Taybi Syndrome Patients

verfasst von: Francesco Saettini, Richard Herriot, Elisabetta Prada, Mathilde Nizon, Daniele Zama, Antonio Marzollo, Igor Romaniouk, Vassilios Lougaris, Manuela Cortesi, Alessia Morreale, Rika Kosaki, Fabio Cardinale, Silvia Ricci, Elena Domínguez-Garrido, Davide Montin, Marie Vincent, Donatella Milani, Andrea Biondi, Cristina Gervasini, Raffaele Badolato

Erschienen in: Journal of Clinical Immunology | Ausgabe 6/2020

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Abstract

Although recurrent infections in Rubinstein–Taybi syndrome (RSTS) are common, and probably multifactorial, immunological abnormalities have not been extensively described with only isolated cases or small case series of immune deficiency and dysregulation having been reported. The objective of this study was to investigate primary immunodeficiency (PID) and immune dysregulation in an international cohort of patients with RSTS. All published cases of RSTS were identified. The corresponding authors and researchers involved in the diagnosis of inborn errors of immunity or genetic syndromes were contacted to obtain up-to-date clinical and immunological information. Ninety-seven RSTS patients were identified. For 45 patients, we retrieved data from the published reports while for 52 patients, a clinical update was provided. Recurrent or severe infections, autoimmune/autoinflammatory complications, and lymphoproliferation were observed in 72.1%, 12.3%, and 8.2% of patients. Syndromic immunodeficiency was diagnosed in 46.4% of individuals. Despite the broad heterogeneity of immunodeficiency disorders, antibody defects were observed in 11.3% of subjects. In particular, these patients presented hypogammaglobulinemia associated with low B cell counts and reduction of switched memory B cell numbers. Immunoglobulin replacement therapy, antibiotic prophylaxis, and immunosuppressive treatment were employed in 16.4%, 8.2%, and 9.8% of patients, respectively. Manifestations of immune dysfunctions, affecting mostly B cells, are more common than previously recognized in patients with RSTS. Full immunological assessment is warranted in these patients, who may require detailed investigation and specific supportive treatment.
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Metadaten
Titel
Prevalence of Immunological Defects in a Cohort of 97 Rubinstein–Taybi Syndrome Patients
verfasst von
Francesco Saettini
Richard Herriot
Elisabetta Prada
Mathilde Nizon
Daniele Zama
Antonio Marzollo
Igor Romaniouk
Vassilios Lougaris
Manuela Cortesi
Alessia Morreale
Rika Kosaki
Fabio Cardinale
Silvia Ricci
Elena Domínguez-Garrido
Davide Montin
Marie Vincent
Donatella Milani
Andrea Biondi
Cristina Gervasini
Raffaele Badolato
Publikationsdatum
27.06.2020
Verlag
Springer US
Erschienen in
Journal of Clinical Immunology / Ausgabe 6/2020
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-020-00808-4

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