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01.12.2018 | Original investigation | Ausgabe 1/2018 Open Access

Cardiovascular Diabetology 1/2018

Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2018
Autoren:
Selma Bouthoorn, Aisha Gohar, Gideon Valstar, Hester M. den Ruijter, J. B. Reitsma, Arno W. Hoes, Frans H. Rutten, the Queen of Hearts Consortium
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12933-018-0690-3) contains supplementary material, which is available to authorized users.
Selma Bouthoorn and Aisha Gohar contributed equally to this work

Abstract

Background

Type 2 diabetes mellitus (T2D) is associated with the development of left ventricular systolic dysfunction (LVSD) and heart failure with reduced ejection fraction (HFrEF). T2D patients with LVSD are at higher risk of mortality and morbidity than patients without LVSD, while progression of LVSD can be delayed or halted by the use of proven therapies. As estimates of the prevalence are scarce and vary considerably, the aim of this study was to retrieve summary estimates of the prevalence of LVSD/HFrEF in T2D and to see if there were any sex differences.

Methods

A systematic search of Medline and Embase was performed to extract the prevalence of LVSD/HFrEF in T2D (17 studies, mean age 50.1 ± 6.3 to 71.5 ± 7.5), which were pooled using random-effects meta-analysis.

Results

The pooled prevalence of LVSD was higher in hospital populations (13 studies, n = 5835, 18% [95% CI 17–19%]), than in the general population (4 studies, n = 1707, 2% [95% CI 2–3%]). Seven studies in total reported sex-stratified prevalence estimates (men: 7% [95% CI 5–8%] vs. women: 1.3% [95% CI 0.0.2.2%]). The prevalence of HFrEF was available in one general population study (5.8% [95% CI 3.7.6%], men: 6.8% vs. women: 3.0%).

Conclusions

The summary prevalence of LVSD is higher among T2D patients from a hospital setting compared with from the general population, with a higher prevalence in men than in women in both settings. The prevalence of HFrEF among T2D in the population was only assessed in a single study and again was higher among men than women.
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