Lower limb amputation is correlated with considerable impairments in health-related quality of life (HRQOL) in veterans. The aim of this study is to determine the prevalence of metabolic syndrome (MetS) in veterans with bilateral lower limb amputation and to identify its association with HRQOL.
This cross-sectional study was conducted on 235 Iranian male veterans with bilateral lower limb amputation. Demographics, anthropometrics, and biochemical measurements were assessed and MetS was defined by National Cholesterol Education Program Adult Treatment Panel III definition. HRQOL was assessed using the 36-item Short Form Health Survey (SF-36) questionnaire which measures eight health-related domains. The scores were compared between two groups of bilateral lower limb Amputees who have diagnosed with and without MetS.
The response rate was 40.7% and the mean age of the amputees was 52.05 years. 62.1% of participants were suffering from MetS (95% CI: 55.9%–68.4%). Patients with MetS were observed to have higher weight, waist and hip circumferences, FBS, TG, LDL and liver enzymes concentrations (P < 0.05). Although scores on all 8 subscales of SF-36 were low, no significant difference was observed in HRQOL scores between amputees with and without MetS. Moreover, the risk of MetS was not significantly different across subjects in the highest compared to the lowest quartile category of HRQOL scores.
Prevalence of MetS in veterans with bilateral lower limb amputation was higher and their HRQOL was lower compared to general population. Some strategies are needed to reduce the risk of cardiovascular diseases among this susceptible population.
Babiæ-Banaszak A, Kovaèiæ L, Kovaèeviæ L, Vuletiæ G, Mujkiæ A, Ebling Z. Impact of war on health related quality of life in Croatia: population study. Croat Med J. 2002;43(4):396–402.
Soroush A, Falahati F, Zargar M, Soroush M, Khateri S, Khaji A. Amputations due to landmine and unexploded ordnances in post-war Iran. Arch Iran Med. 2008;11(6):595–7. PubMed
Rahimi A, Masoumi M, Soroush M, Mousavi B. Orthopedic complications in bilateral lower limb amputation. IJOS. 2009;7(2):58–63.
Rose H, Schweitzer P, Charoenkul V, Schwartz E. Cardiovascular disease risk factors in combat veterans after traumatic leg amputations. Arch Phys Med Rehabil. 1987;68(1):20–3. PubMed
Kurdibaylo SF. Obesity and metabolic disorders in adults with lower limb amputation. J Rehabil Res Dev. 1996;33(4):387. PubMed
Program NCE. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) fi-nal report. Circulation. 2002;106(25):3143-421..
Fazizi F, Esmaillzadeh A, Mirmiran FP. Obesity and cardiovascular disease risk factors in Tehran adults: a population-based study. East Mediterr Health J. 2004;10(6):887–97. PubMed
Azizi F, Hadaegh F, Khalili D, Esteghamati A, Hosseinpanah F, Delavari A, et al. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian National Committee of Obesity. Arch Iran Med. 2010;13(5):426–8. PubMed
Maleki F, Sayehmiri K, Sayehmiri F, Kiani F, Nasiri S, Mohhammadi H, Emraii M. Metabolic syndrome prevalence in Iran: a systematic review and meta-analysis. J Kermanshah Univ Med Sci. 2014;18:242–50.
Magalhães P, Capingana DP, Silva AB, Capunge IR, Gonçalves MA. Arterial stiffness in lower limb amputees. Clin Med Insights Circ Respir Pulm Med. 2011;5:49-56.
Ejtahed HS, Bahadoran Z, Mirmiran P, Azizi F. Sugar-Sweetened Beverage Consumption Is Associated with Metabolic Syndrome in Iranian Adults: Tehran Lipid and Glucose Study. Endocrinol Metab (Seoul). 2015;30(3):334–42. CrossRef
Fallah MS, Sedaghatikhayat B, Guity K, Akbari F, Azizi F, Daneshpour MS. The Relation between Metabolic Syndrome Risk Factors and Genetic Variations of Apolipoprotein V in Relation with Serum Triglyceride and HDL-C Level. Arch Iran Med. 2016;19(1):46–50. PubMed
Lopez-Garcia E, Guallar-Castillon P, Garcia-Esquinas E, Rodriguez-Artalejo F. Metabolically healthy obesity and health-related quality of life: A prospective cohort study. Clin Nutr. 2016. doi: 10.1016/j.clnu.2016.04.028.
- Prevalence of metabolic syndrome and health-related quality of life in war-related bilateral lower limb amputees
- BioMed Central
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