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10.02.2021 | Neurology • Original Article

Prevalence of restless leg syndrome and effects on quality of life during pregnancy

verfasst von: Nazan Tuna Oran, Esma Yuksel, Sebnem Ruzgar

Erschienen in: Sleep and Breathing | Ausgabe 4/2021

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Abstract

Purpose

Restless leg syndrome (RLS) is a movement disorder which constitutes the most common and major risk group during pregnancy. The purpose of this study was to determine prevalence and severity of RLS during pregnancy and to investigate the effect of RLS on quality of life in pregnant women.

Methods

This cross-sectional study was conducted in antenatal clinics of four different public hospitals. Data collected were pregnancy assessment form, RLS diagnostic criteria form, RLS severity scale, and SF-12 quality of life scale.

Results

Among 718 pregnant women, mean age was 28.3±5.9 years (range 19 to 45). According to the diagnostic criteria of RLS, RLS prevalence was 22% (n=159). Of the 159 women with RLS, 41% had moderate severity and 40% had severe RLS. Prevalence of RLS in pregnant women increased with gestational week, working time during pregnancy, weight before pregnancy, total weight gain during pregnancy, and pre-pregnancy body mass index. Physical health scores, physical functioning scores, pain scores, emotional role difficulty scores, and social function scores were significantly lower in the pregnant women with RLS than without RLS (p <0.05).

Conclusions

Approximately one-fifth of the pregnant women had RLS, mostly in the third trimester, and the severity of RLS was predominantly moderate and severe. Pregnant women with RLS had poorer quality of life than pregnant women without RLS.

Hueston WJ, Kasik-Miller S (1998) Changes in functional health status during normal pregnancy. J Fam Pract 47:209–212PubMed

Ramírez-Vélez R (2011) Pregnancy and health-related quality of life: a cross sectional study. Colomb Med 42:476–481. https://doi.org/10.25100/cm.v42i4.948CrossRef

Pesavento F, Marconcini E, Drago D (2005) Quality of life and depression in normal and in high-risk pregnancy. Analysis of a sample of 100 women. Minerva Ginecol 57:451–460PubMed

Calou CGP, Pinheiro AKB, Castro RCMB, de Oliveira MF, de Souza Aquino P, Antezana FJ (2014) Health related quality of life of pregnant women and associated factors: an integrative review. Health (Irvine Calif) 6:2375–2387. https://doi.org/10.4236/health.2014.618273CrossRef

Biaggi A, Conroy S, Pawlby S, Pariante CM (2016) Identifying the women at risk of antenatal anxiety and depression: a systematic review. J Affect Disord 191:62–77CrossRef

Prosperetti C, Manconi M (2015) Restless legs syndrome/Willis-Ekbom disease and pregnancy. Sleep Med Clin 10:323–329CrossRef

Yeh P, Walters AS, Tsuang JW (2012) Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath 16:987–1007. https://doi.org/10.1007/s11325-011-0606-xCrossRefPubMed

Lee KA, Zaffke ME, Baratte-Beebe K (2001) Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Women’s Heal Gender-Based Med 10:335–341. https://doi.org/10.1089/152460901750269652CrossRef

Suzuki K, Ohida T, Sone T, Takemura S, Yokoyama E, Miyake T, Harano S, Motojima S, Suga M, Ibuka E (2003) The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 26:673–677. https://doi.org/10.1093/sleep/26.6.673CrossRefPubMed

10.

Manconi M, Govoni V, De Vito A et al (2004) Pregnancy as a risk factor for restless legs syndrome. Sleep Med 5:305–308. https://doi.org/10.1016/j.sleep.2004.01.013CrossRefPubMed

11.

Hensley JG (2009) Leg cramps and restless legs syndrome during pregnancy. J Midwifery Women’s Heal 54:211–218. https://doi.org/10.1016/j.jmwh.2009.01.003CrossRef

12.

Chen S-J, Shi L, Bao Y-P, Sun YK, Lin X, Que JY, Vitiello MV, Zhou YX, Wang YQ, Lu L (2018) Prevalence of restless legs syndrome during pregnancy: a systematic review and meta-analysis. Sleep Med Rev 40:43–54. https://doi.org/10.1016/j.smrv.2017.10.003CrossRefPubMed

13.

Khan M, Mobeireek N, Al-Jahdali Y et al (2018) The prevalence of restless leg syndrome among pregnant Saudi women. Avicenna J Med 8:18–23. https://doi.org/10.4103/ajm.ajm_123_17CrossRefPubMedPubMedCentral

14.

Şahin FK, Köken G, Coşar E et al (2007) Gebelerde huzursuz bacak sendromu sıklığı. Türk Jinekoloji ve Obstet Dern Derg 4:246–249

15.

Tunç T, Karadaǧ YS, Doǧulu F, Inan LE (2007) Predisposing factors of restless legs syndrome in pregnancy. Mov Disord 22:627–631. https://doi.org/10.1002/mds.21291CrossRefPubMed

16.

Ismailogullari S, Ozturk A, Mazicioglu MM et al (2010) Restless legs syndrome and pregnancy in Kayseri, Turkey: a hospital based survey. Sleep Biol Rhythms 8:137–143. https://doi.org/10.1111/j.1479-8425.2010.00437.xCrossRef

17.

Yüksel B, Seven A, Ildız Y et al (2015) Restless leg syndrome in pregnancy. Jinekoloji - Obstet Neonatoloji Tıp Derg 12:144–146

18.

Güler S, Turan FN (2015) Turkish version of the Johns Hopkins Restless Legs Syndrome Quality of Life Questionnaire (RLS-QoL): validity and reliability study. Qual Life Res 24:2789–2794CrossRef

19.

Wesström J, Nilsson S, Sundström-Poromaa I, Ulfberg J (2010) Health-related quality of life and restless legs syndrome among women in Sweden. Psychiatry Clin Neurosci 64:547–579. https://doi.org/10.1111/j.1440-1819.2010.02116.xCrossRef

20.

Minár M, Habánova H, Rusňák I et al (2013) Prevalence and impact of restless legs syndrome in pregnancy. Neuroendocrinol Lett 34:366–371PubMed

21.

Eichler J, Schmidt R, Hiemisch A, Kiess W, Hilbert A (2019) Gestational weight gain, physical activity,sleep problems, substance use, and foodintake as proximal risk factors of stress anddepressive symptoms during pregnancy. BMC Pregnancy Childbirth 19:1–14. https://doi.org/10.1186/s12884-019-2328-1CrossRef

22.

Montplaisir J, Boucher S, Poirier G, Lavigne G, Lapierre O, Lespérance P (1997) Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord 12:61–65. https://doi.org/10.1002/mds.870120111CrossRefPubMed

23.

Rijsman R, de Weerd AW (1999) Secondary periodic limb movement disorder and restless legs syndrome. Sleep Med Rev 3:147–158CrossRef

24.

Skomro RP, Ludwig S, Salamon E, Kryger MH (2001) Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Med 2:417–422. https://doi.org/10.1016/S1389-9457(01)00110-1CrossRefPubMed

25.

Ramirez JO, Cabrera SAS, Hidalgo H, Cabrera SG, Linnebank M, Bassetti CL, Kallweit U (2013) Is preeclampsia associated with restless legs syndrome? Sleep Med 14:894–896. https://doi.org/10.1016/j.sleep.2013.03.013CrossRefPubMed

26.

Nodine PM, Matthews EE (2013) Common sleep disorders: management strategies and pregnancy outcomes. J Midwifery Women’s Heal 58:368–377. https://doi.org/10.1111/jmwh.12004CrossRef

27.

Ghanei Gheshlagh R, Toloeipoor Lanjavani T, Lazari N, Moslemi B (2014) Comparison of the quality of life in pregnant women with and without restless legs syndrome. J Clin Nurs Midwifery 3:54–61

28.

Akbas P, Sözbir SY (2019) Restless legs syndrome and quality of life in pregnant women. Rev Assoc Med Bras 65:618–624. https://doi.org/10.1590/1806-9282.65.5.618CrossRefPubMed

29.

Telarovic S, Condic L, Telarovic I (2017) Restless legs syndrome in pregnancy: frequency and impact on quality of life and sleep. Mov Disord 32:111

30.

Walters AS, Aldrich MS, Allen R, Ancoli-Israel S, Buchholz D, Chokroverty S, Coccagna G, Earley C, Ehrenberg B, Feest TG, Hening W, Kavey N, Lavigne G, Lipinski J, Lugaresi E, Montagna P, Montplaisir J, Mosko SS, Oertel W, Picchietti D, Pollmächer T, Shafor R, Smith RC, Telstad W, Trenkwalder C, von Scheele C, Walters AS, Ware JC, Zucconi M (1995) Toward a better definition of the restless legs syndrome. Mov Disord 10:634–642. https://doi.org/10.1002/mds.870100517CrossRefPubMed

31.

Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J, Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institutes of Health, International Restless Legs Syndrome Study Group (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101–119. https://doi.org/10.1016/S1389-9457(03)00010-8CrossRefPubMed

32.

The International Restless Legs Syndrome Study Group (2003) Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 4:121–132CrossRef

33.

Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB, International Restless Legs Syndrome Study Group (2014) Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria-history, rationale, description, and significance. Sleep Med 15:860–873. https://doi.org/10.1016/j.sleep.2014.03.025CrossRefPubMed

34.

Bilgilisoy FM, Çakır T (2015) Güncel tani kriterleri ile huzursuz bacak sendromu. Turk Osteoporoz Derg 21:87–95. https://doi.org/10.4274/tod.71601CrossRef

35.

Koçyiğit H, Aydemir Ö, Fişek G et al (1999) Reliability and validity of the Turkish Version of Short Form-36 (SF-36). İlaç ve Tedavi Derg 12:102–106

36.

Ataoğlu S, Ankaralı H, Ankaralı S (2017) Fibromiyalji hastalarının yaşam kalitesini değerlendirmede kullanılan ölçeklerin karşılaştırılması. Anadolu Klin Tıp Bilim Derg 22:85–94. https://doi.org/10.21673/anadoluklin.285068CrossRef

37.

Alves DAG, de Carvalho LBC, de Morais JF, do Prado GF (2010) Restless legs syndrome during pregnancy in Brazilian women. Sleep Med 11:1049–1054. https://doi.org/10.1016/j.sleep.2010.06.006CrossRefPubMed

38.

Sikandar R, Khealani BA, Wasay M (2009) Predictors of restless legs syndrome in pregnancy: a hospital based cross sectional survey from Pakistan. Sleep Med 10:676–678. https://doi.org/10.1016/j.sleep.2008.06.011CrossRefPubMed

39.

Picchietti DL, Hensley JG, Bainbridge JL, Lee KA, Manconi M, McGregor J, Silver RM, Trenkwalder C, Walters AS, International Restless Legs Syndrome Study Group (IRLSSG) (2015) Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev 22:64–77. https://doi.org/10.1016/j.smrv.2014.10.009CrossRefPubMed

40.

Chen PH, Liou KC, Chen CP, Cheng SJ (2012) Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. Sleep Med 13:1153–1157. https://doi.org/10.1016/j.sleep.2012.06.008CrossRefPubMed

41.

Oyieng’O DO, Kirwa K, Tong I et al (2016) Restless legs symptoms and pregnancy and neonatal outcomes. Clin Ther 38:256–264. https://doi.org/10.1016/j.clinthera.2015.11.021CrossRefPubMed

42.

Esposito G, Odelli V, Romiti L, Chiaffarino F, di Martino M, Ricci E, Mauri PA, Bulfoni A, Parazzini F (2019) Prevalence and risk factors for restless legs syndrome during pregnancy in a Northern Italian population. J Obstet Gynaecol (Lahore) 39:480–484. https://doi.org/10.1080/01443615.2018.1525341CrossRef

43.

Liu G, Li L, Zhang J, Xue R, Zhao X, Zhu K, Wang Y, Xiao L, Shangguan J (2016) Restless legs syndrome and pregnancy or delivery complications in China: a representative survey. Sleep Med 17:158–162. https://doi.org/10.1016/j.sleep.2015.02.541CrossRefPubMed

44.

Nasir A, Khuwaja AK (2007) Restless legs syndrome: common but frequently unrecognized disorder in pregnancy. J Pak Med Assoc 57:164PubMed

45.

Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, Ferini-Strambi L (2005) Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165:1286–1292. https://doi.org/10.1001/archinte.165.11.1286CrossRefPubMed

46.

Demirci S, Şahin AT (2016) The frequency of restless legs syndrome and relationship with quality of life among university students. Cukurova Med J 41:423–428. https://doi.org/10.17826/cukmedj.200483CrossRef

47.

Güzel S, Kurtcebe ZÖ, Şencan S, Turhan N (2013) Hormonal influences on the severity of restless legs syndrome, sleep and health-related quality of life in women of reproductive age. Turk J Phys Med Rehab 59:45–51

Titel: Prevalence of restless leg syndrome and effects on quality of life during pregnancy
verfasst von: Nazan Tuna Oran
Esma Yuksel
Sebnem Ruzgar
Publikationsdatum: 10.02.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2021
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02311-5

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Prevalence of restless leg syndrome and effects on quality of life during pregnancy

Abstract

Purpose

Methods

Results

Conclusions

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