nach oben

06.09.2024 | Review

Prevalence of thiamine deficiency in anorexia nervosa: a systematic review and narrative synthesis

verfasst von: Michael O’Brien, Rachael Quirke, Roisin Gowan, Fiona McNicholas

Erschienen in: European Child & Adolescent Psychiatry

Einloggen, um Zugang zu erhalten

Abstract

Thiamine is an essential vitamin that plays a crucial role in many biochemical processes in the body. Anorexia nervosa (AN) is one potential cause of a state of deficiency which can result in grave medical sequelae. There is limited available evidence of the prevalence of thiamine deficiency in patients who suffer from AN. The current study aimed to systematically review all available evidence on the prevalence of thiamine deficiency in cohorts with AN. Studies were included where thiamine status in a group of participants with AN was measured, either through self-reporting or objective measurement. Eight databases (Scopus, CINAHL complete, Medline complete, EMBASE, WEB OF SCIENCE, PROSPERO, COCHRANE DATABASE OF SYSTEMATIC REVIEWS and Cochrane Central Register of Controlled Trials (CENTRAL) were searched. PRISMA guidelines were followed. The study was registered on PROSPERO. A minimum of two researchers conducted each part of the review. The search identified 42 articles whose full texts were screened for eligibility, with 17 retained for qualitative synthesis. The prevalence rates of thiamine deficiency in AN varied from 5.9% to 100% when based on self-report dietary intake. When objective measurements were taken, rates ranged from 0% to 56.7%. The review suggested that age, body mass index (BMI), duration of illness and subtype of AN were not associated with thiamine status. The limited available evidence suggested that the use of supplements, prior treatment and higher energy intakes were associated with a reduced risk of developing a thiamine deficiency among individuals with AN. Poor study methodology including small sample size, inconsistent deficiency definition and study heterogeneity limits the conclusions that can be drawn. Ultimately, there is insufficient strength of evidence to draw definitive clinical recommendations. This review highlights the need for further studies with more robust methodology to help further inform clinical practice.

Nur mit Berechtigung zugänglich

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5), 5th edn. American Psychiatric PublishingCrossRef

Norrington A, Stanley R, Tremlett M, Birrell G (2012) Medical management of acute severe anorexia nervosa. Arch Dis Child Educ Pract Ed 97(2):48–54. https://doi.org/10.1136/adc.2010.199885CrossRefPubMed

Oudman E, Wijnia JW, Oey MJ, van Dam MJ, Postma A (2018) Preventing Wernicke’s encephalopathy in anorexia nervosa: a systematic review. Psychiatry Clin Neurosci 72(10):774–779. https://doi.org/10.1111/pcn.12735CrossRefPubMed

Kattoor AJ, Goel A, Mehta JL (2018) Thiamine therapy for heart failure: a promise or fiction? Cardiovasc Drugs Ther 32(4):313–317. https://doi.org/10.1007/s10557-018-6808-8CrossRefPubMed

Polegato BF, Pereira AG, Azevedo PS, Costa NA, Zornoff LAM, Paiva SAR, Minicucci MF (2019) Role of thiamin in health and disease. Nutr Clin Pract 34(4):558–564. https://doi.org/10.1002/ncp.10234CrossRefPubMed

Institute of Medicine (2006) Dietary reference intakes: the essential guide to nutrient requirements. The National Academies Press

Scarpellini E, Cafarotti S, Cesario A, Lococo F, Margaritora S, Gabrielli M, Tortora A, Gasbarrini A, Granone P (2012) A case of vomiting in an anorexic achalasic patient. Eur Rev Med Pharmacol Sci 16(Suppl 4):44–47PubMed

Saad L, Silva LF, Banzato CE, Dantas CR, Garcia C Jr (2010) Anorexia nervosa and Wernicke–Korsakoff syndrome: a case report. J Med Case Rep 4:217. https://doi.org/10.1186/1752-1947-4-217CrossRefPubMedPubMedCentral

McCormick LM, Buchanan JR, Onwuameze OE, Pierson RK, Paradiso S (2011) Beyond alcoholism: Wernicke–Korsakoff syndrome in patients with psychiatric disorders. Cogn Behav Neurol 24(4):209–216. https://doi.org/10.1097/WNN.0b013e31823f90c4CrossRefPubMedPubMedCentral

10.

Winston AP, Jamieson CP, Madira W, Gatward NM, Palmer RL (2000) Prevalence of thiamin deficiency in anorexia nervosa. Int J Eat Disord 28(4):451–454. https://doi.org/10.1002/1098-108x(200012)28:4%3c451::aid-eat14%3e3.0.co;2-iCrossRefPubMed

11.

Hershkowitz E, Reshef A, Munich O, Yosefi B, Markel A (2014) Thiamine deficiency in self-induced refeeding syndrome, an undetected and potentially lethal condition. Case Rep Med 2014:605707. https://doi.org/10.1155/2014/605707CrossRefPubMedPubMedCentral

12.

Renthal W, Marin-Valencia I, Evans PA (2014) Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence. Pediatr Neurol 51(1):100–103. https://doi.org/10.1016/j.pediatrneurol.2014.03.025CrossRefPubMed

13.

Shible AA, Ramadurai D, Gergen D, Reynolds PM (2019) Dry beriberi due to thiamine deficiency associated with peripheral neuropathy and Wernicke’s encephalopathy mimicking Guillain-Barré syndrome: a case report and review of the literature. Am J Case Rep 20:330–334. https://doi.org/10.12659/AJCR.914051CrossRefPubMedPubMedCentral

14.

Crook MA, Sriram K (2014) Thiamine deficiency: the importance of recognition and prompt management. Nutrition 30(7–8):953–954. https://doi.org/10.1016/j.nut.2014.03.003CrossRefPubMed

15.

Whitfield KC, Bourassa MW, Adamolekun B, Bergeron G, Bettendorff L, Brown KH, Cox L, Fattal-Valevski A, Fischer PR, Frank EL, Hiffler L, Hlaing LM, Jefferds ME, Kapner H, Kounnavong S, Mousavi MPS, Roth DE, Tsaloglou MN, Wieringa F, Combs GF Jr (2018) Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann N Y Acad Sci 1430(1):3–43. https://doi.org/10.1111/nyas.13919CrossRefPubMedPubMedCentral

16.

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Open Med 3(3):e123–e130PubMedPubMedCentral

17.

Wohlin C (2014) Guidelines for snowballing in systematic literature studies and a replication in software engineering. In: Proceedings of the 18th International Conference on Evaluation and Assessment in Software Engineering (EASE '14). Association for Computing Machinery, New York, NY, USA, Article 38, pp 1–10. https://doi.org/10.1145/2601248.2601268. Accessed 15 Dec 2019

18.

Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C (2015) Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc 13(3):147–153. https://doi.org/10.1097/XEB.0000000000000054CrossRefPubMed

19.

Beaumont PJ, Chambers TL, Rouse L, Abraham SF (1981) The diet composition and nutritional knowledge of patients with anorexia nervosa. J Hum Nutr 35(4):265–273PubMed

20.

Thibault L, Roberge AG (1987) The nutritional status of subjects with anorexia nervosa. Int J Vitam Nutr Res 57(4):447–452PubMed

21.

Moreiras-Varela O, Nuñez C, Carbajal A, Morande G (1990) Nutritional status and food habits assessed by dietary intake and anthropometrical parameters in anorexia nervosa. Int J Vitam Nutr Res 60(3):267–274PubMed

22.

van der Ster WG, Norring C, Lennernäs MA, Holmgren S (1995) Food selection in anorectics and bulimics: food items, nutrient content and nutrient density. J Am Coll Nutr 14(3):271–277. https://doi.org/10.1080/07315724.1995.10718507CrossRef

23.

Hadigan CM, Anderson EJ, Miller KK, Hubbard JL, Herzog DB, Klibanski A, Grinspoon SK (2000) Assessment of macronutrient and micronutrient intake in women with anorexia nervosa. Int J Eat Disord 28(3):284–292. https://doi.org/10.1002/1098-108x(200011)28:3%3c284::aid-eat5%3e3.0.co;2-gCrossRefPubMed

24.

Misra M, Tsai P, Anderson EJ, Hubbard JL, Gallagher K, Soyka LA, Miller KK, Herzog DB, Klibanski A (2006) Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents. Am J Clin Nutr 84(4):698–706. https://doi.org/10.1093/ajcn/84.4.698CrossRefPubMed

25.

Jáuregui-Lobera I, Bolaños-Ríos P (2009) Choice of diet in patients with anorexia nervosa. Nutr Hosp 24(6):682–687PubMed

26.

Oliveras-López MJ, Ruiz-Prieto I, Bolaños-Ríos P, De la Cerda F, Martín F, Jáuregui-Lobera I (2015) Antioxidant activity and nutritional status in anorexia nervosa: effects of weight recovery. Nutrients 7(4):2193–2208. https://doi.org/10.3390/nu7042193CrossRefPubMedPubMedCentral

27.

Raatz SK, Jahns L, Johnson LK, Crosby R, Mitchell JE, Crow S, Peterson C, Le Grange D, Wonderlich SA (2015) Nutritional adequacy of dietary intake in women with anorexia nervosa. Nutrients 7(5):3652–3665. https://doi.org/10.3390/nu7053652CrossRefPubMedPubMedCentral

28.

Chiurazzi C, Cioffi I, De Caprio C, De Filippo E, Marra M, Sammarco R, Di Guglielmo ML, Contaldo F, Pasanisi F (2017) Adequacy of nutrient intake in women with restrictive anorexia nervosa. Nutrition 38:80–84. https://doi.org/10.1016/j.nut.2017.02.004CrossRefPubMed

29.

van Binsbergen CJ, Odink J, Van den Berg H, Koppeschaar H, Coelingh Bennink HJ (1988) Nutritional status in anorexia nervosa: clinical chemistry, vitamins, iron and zinc. Eur J Clin Nutr 42(11):929–937PubMed

30.

Castro J, Deulofeu R, Gila A, Puig J, Toro J (2004) Persistence of nutritional deficiencies after short-term weight recovery in adolescents with anorexia nervosa. Int J Eat Disord 35(2):169–178. https://doi.org/10.1002/eat.10249CrossRefPubMed

31.

Hanachi M, Dicembre M, Rives-Lange C, Ropers J, Bemer P, Zazzo JF, Poupon J, Dauvergne A, Melchior JC (2019) Micronutrients deficiencies in 374 severely malnourished anorexia nervosa inpatients. Nutrients 11(4):792. https://doi.org/10.3390/nu11040792CrossRefPubMedPubMedCentral

32.

Bahat H, Reisler G, Brandriss N, Bar-Chaim A, Goldman M (2020) Thiamine deficiency in adolescents with eating disorders: a prospective cohort study. Nutrients 12(5):1396. https://doi.org/10.3390/nu12051396CrossRefPubMedPubMedCentral

33.

Parker E, Maister T, Stefoska-Needham A, Wearne C, Anderson G, Gomes L, Clarke S, Kohn M (2020) An audit of the changes in thiamine levels during higher caloric nutritional rehabilitation of adolescent patients hospitalised with a restrictive eating disorder. J Eat Disord 8:41. https://doi.org/10.1186/s40337-020-00318-zCrossRefPubMedPubMedCentral

34.

Philipp E, Pirke KM, Seidl M, Tuschl RJ, Fichter MM, Eckert M, Wolfram G (1989) Vitamin status in patients with anorexia nervosa and bulimia nervosa. Int J Eat Disord 8(2):209–218CrossRef

35.

Poslusna K, Ruprich J, de Vries JH, Jakubikova M, van’t Veer P, (2009) Misreporting of energy and micronutrient intake estimated by food records and 24 hour recalls, control and adjustment methods in practice. Br J Nutr 101(Suppl 2):S73-85. https://doi.org/10.1017/S0007114509990602CrossRefPubMed

36.

Novotny JA, Rumpler WV, Riddick H, Hebert JR, Rhodes D, Judd JT, Baer DJ, McDowell M, Briefel R (2003) Personality characteristics as predictors of underreporting of energy intake on 24-hour dietary recall interviews. J Am Diet Assoc 103(9):1146–1151. https://doi.org/10.1016/s0002-8223(03)00975-1CrossRefPubMed

37.

Schebendach JE, Porter KJ, Wolper C, Walsh BT, Mayer LE (2012) Accuracy of self-reported energy intake in weight-restored patients with anorexia nervosa compared with obese and normal weight individuals. Int J Eat Disord 45(4):570–574. https://doi.org/10.1002/eat.20973CrossRefPubMedPubMedCentral

38.

European Food Safety Authority (2006) Tolerable Upper Intake Levels for Vitamins and Minerals, pp 93–94. https://web.archive.org/web/20160316225123/http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf. Accessed 19 Dec 2019

Titel: Prevalence of thiamine deficiency in anorexia nervosa: a systematic review and narrative synthesis
verfasst von: Michael O’Brien
Rachael Quirke
Roisin Gowan
Fiona McNicholas
Publikationsdatum: 06.09.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-024-02576-7

Neu im Fachgebiet Psychiatrie

„Wir wollen die Bedeutung von Gen- und Umwelteinflüssen besser verstehen“

Bipolare Störung
Interview

Eine Mutation in einem einzelnen Gen kann bei Mäusen eine Art Bipolarstörung auslösen. PD Dr. Jan Deussing vom Max-Planck-Institut für Psychiatrie in München sieht in solchen Tiermodellen eine Möglichkeit, den Ursachen der Erkrankung auf den Grund zu gehen.

Suizidassistenz erhöht Suizidzahlen: Aktuelle Ergebnisse der geplanten S3-Leitlinie

DGPPN 2024
Kongressbericht

Erstmals wird in Deutschland eine S3-Leitlinie zum Thema Suizidalität erarbeitet. Ziel ist es, die Versorgung in suizidalen Krisen durch einheitliche Standards zu verbessern. Erste Ergebnisse der bisherigen Leitlinienarbeit wurden auf dem DGPPN-Kongress vorgestellt.

Einer von sieben Frauen macht die Menopause sehr zu schaffen

15.01.2025
Menopause
Nachrichten

Von mäßigen bis schweren vasomotorischen Beschwerden sind 14,7% der Frauen in der Postmenopause betroffen. Das haben kanadische Forscherinnen in einer Subgruppenanalyse der WARM-Studie herausgefunden.

Depressive Senioren fahren besonders riskant

14.01.2025
Altersdepression
Nachrichten

Beim Autofahren machen ältere Depressive häufiger eine Vollbremsung, gehen öfter zu schnell in Kurven und halten sich seltener an Tempolimits als Senioren ohne Depression. Offenbar scheint eine Depression eine riskante Fahrweise im Alter zu verstärken.

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen