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Erschienen in: Medical Microbiology and Immunology 5-6/2018

03.07.2018 | Review

Preventing vertical virus infections: the role of serologic screening of pregnant women

verfasst von: Annemarie Berger, Hans Wilhelm Doerr

Erschienen in: Medical Microbiology and Immunology | Ausgabe 5-6/2018

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Abstract

Several virus infections affect the pregnancy itself as well as the foetal development (rubella, PVB19, VZV, HSV, HCMV, HBV, HIV). Prevention can be established by vaccination or an assessment of the immunity status as well as by chemotherapy. The following review provides an update to current aspects focusing on the role of serologic screening.
Literatur
2.
Zurück zum Zitat Vauloup-Fellous C (2018) Standardization of rubella immunoassays. J Clin Virol 102:34–38CrossRef Vauloup-Fellous C (2018) Standardization of rubella immunoassays. J Clin Virol 102:34–38CrossRef
5.
Zurück zum Zitat Bonvicini F. Bua G, Gallinella G (2017) Parvovirus B19 infection in pregnancy-awareness and opportunities. Curr Opin Virol 27:8–14CrossRef Bonvicini F. Bua G, Gallinella G (2017) Parvovirus B19 infection in pregnancy-awareness and opportunities. Curr Opin Virol 27:8–14CrossRef
6.
Zurück zum Zitat Public Health Laboratory Service Working Party on Fifth Disease (1990) Prospective study of human parvovirus (B19) infection in pregnancy. BMJ 300:1166–1170CrossRef Public Health Laboratory Service Working Party on Fifth Disease (1990) Prospective study of human parvovirus (B19) infection in pregnancy. BMJ 300:1166–1170CrossRef
7.
Zurück zum Zitat Rodis JF, Quinn DL, Gary GW Jr, Anderson LJ (1990) Management and outcomes of pregnancies complicated by human B19 parvovirus infection: a prospective study. Am J Obstet Gynecol 163:1168–1171CrossRef Rodis JF, Quinn DL, Gary GW Jr, Anderson LJ (1990) Management and outcomes of pregnancies complicated by human B19 parvovirus infection: a prospective study. Am J Obstet Gynecol 163:1168–1171CrossRef
8.
Zurück zum Zitat Reinheimer C, Allwinn R, Doerr HW, Wittek M (2010) Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors. Infection 38:381–385CrossRef Reinheimer C, Allwinn R, Doerr HW, Wittek M (2010) Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors. Infection 38:381–385CrossRef
9.
Zurück zum Zitat Barlinn R, Rollag H, Trogstad L et al (2017) High incidence of maternal parvovirus B19 infection in a large unselected population-based pregnancy cohort in Norway. J Clin Virol 94:57–62CrossRef Barlinn R, Rollag H, Trogstad L et al (2017) High incidence of maternal parvovirus B19 infection in a large unselected population-based pregnancy cohort in Norway. J Clin Virol 94:57–62CrossRef
10.
Zurück zum Zitat Bredl S, Plentz A, Wenzel JJ, Pfister H, Möst J, Modrow S (2011) False-negative serology in patients with acute parvovirus B19 infection. J Clin Virol 51:115–120CrossRef Bredl S, Plentz A, Wenzel JJ, Pfister H, Möst J, Modrow S (2011) False-negative serology in patients with acute parvovirus B19 infection. J Clin Virol 51:115–120CrossRef
11.
Zurück zum Zitat Crane J, Mundle W, Boucoiran I et al (2014) Parvovirus B19 in pregnancy. J Obstet Gynaecol Can 36:1107–1116CrossRef Crane J, Mundle W, Boucoiran I et al (2014) Parvovirus B19 in pregnancy. J Obstet Gynaecol Can 36:1107–1116CrossRef
12.
Zurück zum Zitat Matsuda H, Sakaguchi K, Shibasaki T, Takahashi H, Kawakami Y, Furuya K (2005) Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin. J Perinat Med 33:561–563 Matsuda H, Sakaguchi K, Shibasaki T, Takahashi H, Kawakami Y, Furuya K (2005) Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin. J Perinat Med 33:561–563
13.
Zurück zum Zitat Pasternak B, Hviid A (2010) Use of acyclovir, valacyclovir and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 304:859–866CrossRef Pasternak B, Hviid A (2010) Use of acyclovir, valacyclovir and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 304:859–866CrossRef
14.
Zurück zum Zitat Sauerbrei A, Wutzler P (2007) Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: varicella-zoster virus infections. Med Microbiol Immunol 196:95–102CrossRef Sauerbrei A, Wutzler P (2007) Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: varicella-zoster virus infections. Med Microbiol Immunol 196:95–102CrossRef
15.
Zurück zum Zitat Wiese-Posselt M, Siedler A, Mankertz A et al (2017) Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany. BMC Infect Dis 17:356CrossRef Wiese-Posselt M, Siedler A, Mankertz A et al (2017) Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany. BMC Infect Dis 17:356CrossRef
16.
Zurück zum Zitat Werner RN, Nikkels AF, Marinović B et al (2017) European consensus-based (S2k) guideline on the management of herpes zoster—guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), part 1: diagnosis. J Eur Acad Dermatol Venereol 31:9–19CrossRef Werner RN, Nikkels AF, Marinović B et al (2017) European consensus-based (S2k) guideline on the management of herpes zoster—guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), part 1: diagnosis. J Eur Acad Dermatol Venereol 31:9–19CrossRef
17.
Zurück zum Zitat Doerr HW (2013) Progress in VZV vaccination? Some concerns. Med Microbiol Immunol 202:257–258CrossRef Doerr HW (2013) Progress in VZV vaccination? Some concerns. Med Microbiol Immunol 202:257–258CrossRef
18.
Zurück zum Zitat Wicker S, Rabenau HF, Gottschalk R, Doerr HW, Allwinn R (2007) Seroprevalence of vaccine preventable and blood transmissible viral infections (measles, mumps, rubella, VZV, polio, HBV, HCV and HIV) in medical students. Med Microbiol Immunol 196:145–150CrossRef Wicker S, Rabenau HF, Gottschalk R, Doerr HW, Allwinn R (2007) Seroprevalence of vaccine preventable and blood transmissible viral infections (measles, mumps, rubella, VZV, polio, HBV, HCV and HIV) in medical students. Med Microbiol Immunol 196:145–150CrossRef
19.
Zurück zum Zitat Wittek M, Doerr HW, Allwinn R (2010) Varicella and herpes zoster. Part 1: virology, epidemiology, clinical picture, laboratory diagnostics. Med Klin (Munich) 105:334–338CrossRef Wittek M, Doerr HW, Allwinn R (2010) Varicella and herpes zoster. Part 1: virology, epidemiology, clinical picture, laboratory diagnostics. Med Klin (Munich) 105:334–338CrossRef
20.
Zurück zum Zitat Buxbaum S, Geers M, Gross G, Schöfer H, Rabenau HF, Doerr HW (2003) Epidemiology of herpes simplex virus types 1 and 2 in Germany: what has changed? Med Microbiol Immunol 192:177–181CrossRef Buxbaum S, Geers M, Gross G, Schöfer H, Rabenau HF, Doerr HW (2003) Epidemiology of herpes simplex virus types 1 and 2 in Germany: what has changed? Med Microbiol Immunol 192:177–181CrossRef
21.
Zurück zum Zitat Gupta R, Warren T, Wald A (2007) Genital herpes. Lancet 370:2127–2137CrossRef Gupta R, Warren T, Wald A (2007) Genital herpes. Lancet 370:2127–2137CrossRef
22.
Zurück zum Zitat Kimberlin D (2004) Neonatal herpes simplex infection. Clin Microbiol Rev 17(1):1–13CrossRef Kimberlin D (2004) Neonatal herpes simplex infection. Clin Microbiol Rev 17(1):1–13CrossRef
23.
Zurück zum Zitat Hollier LM, Wendel GD (2008) Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Cochrane Database Syst Rev 1:CD004946 Hollier LM, Wendel GD (2008) Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Cochrane Database Syst Rev 1:CD004946
24.
Zurück zum Zitat Pichler M, Staffler A, Bonometti N, Messner H, Deluca J, Thuile T, Kluge R, Schmuth M, Eisendle K (2015) Premature newborns with fatal intrauterine herpes simplex virus-1 infection: first report of twins and review of the literature. J Eur Acad Dermatol Venereol 29:1216–1220CrossRef Pichler M, Staffler A, Bonometti N, Messner H, Deluca J, Thuile T, Kluge R, Schmuth M, Eisendle K (2015) Premature newborns with fatal intrauterine herpes simplex virus-1 infection: first report of twins and review of the literature. J Eur Acad Dermatol Venereol 29:1216–1220CrossRef
25.
Zurück zum Zitat Doerr HW, Berger A (2014) Vaccination against infectious diseases. What is promising? Med Microbiol Immunol 203:365–371CrossRef Doerr HW, Berger A (2014) Vaccination against infectious diseases. What is promising? Med Microbiol Immunol 203:365–371CrossRef
26.
Zurück zum Zitat Lübeck PR, Doerr HW, Rabenau HF (2010) Epidemiology of human cytomegalovirus (HCMV) in an urban region of Germany: what has changed? Med Microbiol Immunol 199:53–60CrossRef Lübeck PR, Doerr HW, Rabenau HF (2010) Epidemiology of human cytomegalovirus (HCMV) in an urban region of Germany: what has changed? Med Microbiol Immunol 199:53–60CrossRef
27.
Zurück zum Zitat Enders G, Daiminger A, Lindemann L, Knotek F, Bäder U, Exler S, Enders M (2012) Cytomegalovirus (CMV) seroprevalence in pregnant women, bone marrow donors and adolescents in Germany, 1996–2010. Med Microbiol Immunol 201:303–309CrossRef Enders G, Daiminger A, Lindemann L, Knotek F, Bäder U, Exler S, Enders M (2012) Cytomegalovirus (CMV) seroprevalence in pregnant women, bone marrow donors and adolescents in Germany, 1996–2010. Med Microbiol Immunol 201:303–309CrossRef
28.
Zurück zum Zitat Rycel M, Wujcicka W, Zawilińska B, Paradowska E, Suski P, Gaj Z, Wilczyński J, Leśnikowski Z, Nowakowska D (2015) Mixed infections with distinct cytomegalovirus glycoprotein B genotypes in Polish pregnant women, foetuses, and newborns. Eur J Clin Microbiol Infect Dis 34:585–591CrossRef Rycel M, Wujcicka W, Zawilińska B, Paradowska E, Suski P, Gaj Z, Wilczyński J, Leśnikowski Z, Nowakowska D (2015) Mixed infections with distinct cytomegalovirus glycoprotein B genotypes in Polish pregnant women, foetuses, and newborns. Eur J Clin Microbiol Infect Dis 34:585–591CrossRef
29.
Zurück zum Zitat Kagan KO, Hamprecht K (2017) Cytomegalovirus in pregnancy. Arch Gynecol Obstet 296:15–26CrossRef Kagan KO, Hamprecht K (2017) Cytomegalovirus in pregnancy. Arch Gynecol Obstet 296:15–26CrossRef
30.
Zurück zum Zitat Doerr HW (1987) Cytomegalovirus infection in pregnancy. J Virol Methods 17:127–132CrossRef Doerr HW (1987) Cytomegalovirus infection in pregnancy. J Virol Methods 17:127–132CrossRef
31.
Zurück zum Zitat Britt W (2015) Controversies in the natural history of congenital human cytomegalovirus infection: the paradox of infection and disease in offspring of women with immunity prior to pregnancy. Med Microbiol Immunol 204:263–271CrossRef Britt W (2015) Controversies in the natural history of congenital human cytomegalovirus infection: the paradox of infection and disease in offspring of women with immunity prior to pregnancy. Med Microbiol Immunol 204:263–271CrossRef
32.
Zurück zum Zitat Berger A, Reitter A, Harter PN, Buxmann H, Allwinn R, Louwen F, Doerr HW (2011) Problems and challenges in the diagnosis of vertical infection with human cytomegalovirus (CMV): lessons from two accidental cases. J Clin Virol 51:285–288CrossRef Berger A, Reitter A, Harter PN, Buxmann H, Allwinn R, Louwen F, Doerr HW (2011) Problems and challenges in the diagnosis of vertical infection with human cytomegalovirus (CMV): lessons from two accidental cases. J Clin Virol 51:285–288CrossRef
33.
Zurück zum Zitat Doerr HW (2016) Fighting cytomegalovirus-caused diseases: the immunologic approach. Med Microbiol Immunol 205:511–512CrossRef Doerr HW (2016) Fighting cytomegalovirus-caused diseases: the immunologic approach. Med Microbiol Immunol 205:511–512CrossRef
34.
Zurück zum Zitat Lanzieri TM, Dollard SC, Josephson CD, Schmid DS, Bialek SR (2013) Breast milk-acquired cytomegalovirus infection and disease in very low birth weight and premature infants. Pediatrics 131(6):e1937–e1945CrossRef Lanzieri TM, Dollard SC, Josephson CD, Schmid DS, Bialek SR (2013) Breast milk-acquired cytomegalovirus infection and disease in very low birth weight and premature infants. Pediatrics 131(6):e1937–e1945CrossRef
35.
Zurück zum Zitat Reitter A, Buxmann H, Haberl AE, Schlösser R, Kreibich M, Keppler OT, Berger A (2016) Incidence of CMV co-infection in HIV-positive women and their neonates in a tertiary referral centre: a cohort study. Med Microbiol Immunol 205:63–71CrossRef Reitter A, Buxmann H, Haberl AE, Schlösser R, Kreibich M, Keppler OT, Berger A (2016) Incidence of CMV co-infection in HIV-positive women and their neonates in a tertiary referral centre: a cohort study. Med Microbiol Immunol 205:63–71CrossRef
36.
Zurück zum Zitat Wagner N, Kagan KO, Haen S, Schmidt S et al (2014) Effective management and intrauterine treatment of congenital cytomegalovirus infection: review article and case series. J Matern Fetal Neonatal Med 27:209–214CrossRef Wagner N, Kagan KO, Haen S, Schmidt S et al (2014) Effective management and intrauterine treatment of congenital cytomegalovirus infection: review article and case series. J Matern Fetal Neonatal Med 27:209–214CrossRef
37.
Zurück zum Zitat Seidel V, Feiterna-Sperling C, Siedentopf JP, Hofmann J et al (2017) Intrauterine therapy of cytomegalovirus infection with valganciclovir: review of the literature. Med Microbiol Immunol 206:347–354CrossRef Seidel V, Feiterna-Sperling C, Siedentopf JP, Hofmann J et al (2017) Intrauterine therapy of cytomegalovirus infection with valganciclovir: review of the literature. Med Microbiol Immunol 206:347–354CrossRef
38.
Zurück zum Zitat Rawlinson W (2017) Congenital CMV international guidelines are needed to guide diagnosis, prevention and management. Acta Paediatr 106(9):1389–1390CrossRef Rawlinson W (2017) Congenital CMV international guidelines are needed to guide diagnosis, prevention and management. Acta Paediatr 106(9):1389–1390CrossRef
39.
Zurück zum Zitat Hamprecht K, Kagan KO, Schampera M, Jahn G (2018) Impact of pharmacokinetics on the efficiency of CMV-specific hyperimmune globulin treatment in early CMV-primary infection during pregnancy (abstract). In: 28th annual meeting of the Society for Virology, March 14–17, Würzburg, OP 137 Hamprecht K, Kagan KO, Schampera M, Jahn G (2018) Impact of pharmacokinetics on the efficiency of CMV-specific hyperimmune globulin treatment in early CMV-primary infection during pregnancy (abstract). In: 28th annual meeting of the Society for Virology, March 14–17, Würzburg, OP 137
40.
Zurück zum Zitat Plotkin S (2015) The history of vaccination against cytomegalovirus. Med Microbiol Immunol 204:247–254CrossRef Plotkin S (2015) The history of vaccination against cytomegalovirus. Med Microbiol Immunol 204:247–254CrossRef
41.
Zurück zum Zitat Mocarski ES (2015) Stanley Plotkin: the bright spark of cytomegalovirus vaccines. Med Microbiol Immunol 204:243–245CrossRef Mocarski ES (2015) Stanley Plotkin: the bright spark of cytomegalovirus vaccines. Med Microbiol Immunol 204:243–245CrossRef
42.
Zurück zum Zitat Plachter B (2016) Prospects a vaccine for the prevention of congenital cytomegalovirus disease. Med Microbiol Immunol 205:537–547CrossRef Plachter B (2016) Prospects a vaccine for the prevention of congenital cytomegalovirus disease. Med Microbiol Immunol 205:537–547CrossRef
43.
Zurück zum Zitat Mavilia MG, Wu GY (2017) Mechanisms and prevention of vertical transmission in chronic viral hepatitis. J Clin Transl Hepatol 5:119–129 (Review) CrossRef Mavilia MG, Wu GY (2017) Mechanisms and prevention of vertical transmission in chronic viral hepatitis. J Clin Transl Hepatol 5:119–129 (Review) CrossRef
44.
Zurück zum Zitat Nakagawa F, Phillips AN, Lundgren JD (2014) Update on HIV in Western Europe. Curr HIV/AIDS Rep 11:177–185 (Review) CrossRef Nakagawa F, Phillips AN, Lundgren JD (2014) Update on HIV in Western Europe. Curr HIV/AIDS Rep 11:177–185 (Review) CrossRef
45.
Zurück zum Zitat Vrazo AC, Firth J, Amzel A, Sedillo R, Ryan J, Phelps BR (2018) Interventions to significantly improve service uptake and retention of HIV-positive pregnant women and HIV-exposed infants along the PMTCT continuum of care. A systematic review. Trop Med Int Health 23:136–148CrossRef Vrazo AC, Firth J, Amzel A, Sedillo R, Ryan J, Phelps BR (2018) Interventions to significantly improve service uptake and retention of HIV-positive pregnant women and HIV-exposed infants along the PMTCT continuum of care. A systematic review. Trop Med Int Health 23:136–148CrossRef
46.
Zurück zum Zitat Park JS, Pan CQ (2017) Viral factors for HBV mother-to-child transmission. Hepatol Int 11:476–480CrossRef Park JS, Pan CQ (2017) Viral factors for HBV mother-to-child transmission. Hepatol Int 11:476–480CrossRef
47.
Zurück zum Zitat Weis N, Cowan S, Hallager S, Dröse S et al (2017) Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark. Scand J Gastroenterol 52:178–184CrossRef Weis N, Cowan S, Hallager S, Dröse S et al (2017) Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark. Scand J Gastroenterol 52:178–184CrossRef
48.
Zurück zum Zitat Tavakolpour S, Darvishi M, Mirsafaei HS, Ghasemiadl M (2018) Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B infection during pregnancy: a systematic review. Infect Dis (Lond) 50:95–106 Tavakolpour S, Darvishi M, Mirsafaei HS, Ghasemiadl M (2018) Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B infection during pregnancy: a systematic review. Infect Dis (Lond) 50:95–106
49.
Zurück zum Zitat Gerlich WH (2015) Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol 204:39–55CrossRef Gerlich WH (2015) Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol 204:39–55CrossRef
50.
Zurück zum Zitat Shouval D. Roggendorf H, Roggendorf M (2015) Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S vaccine. Med Microbiol Immunol 204:57–68CrossRef Shouval D. Roggendorf H, Roggendorf M (2015) Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S vaccine. Med Microbiol Immunol 204:57–68CrossRef
51.
Zurück zum Zitat Doerr HW (2013) Perspectives of vaccination in adults. Expert Rev Vaccines 12:593–596CrossRef Doerr HW (2013) Perspectives of vaccination in adults. Expert Rev Vaccines 12:593–596CrossRef
Metadaten
Titel
Preventing vertical virus infections: the role of serologic screening of pregnant women
verfasst von
Annemarie Berger
Hans Wilhelm Doerr
Publikationsdatum
03.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Medical Microbiology and Immunology / Ausgabe 5-6/2018
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-018-0549-y

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