Erschienen in:
04.04.2018 | Editorial
Prevention of mother-to-child transmission: the key of hepatitis B virus elimination
verfasst von:
Chih-Lin Lin, Jia-Horng Kao
Erschienen in:
Hepatology International
|
Ausgabe 2/2018
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Excerpt
More than half a century after the initial discovery, hepatitis B virus (HBV) is one of the most common viral infections in humans. With a global heterogeneous prevalence, the HBV epidemic remains a monumental threat of health. In Asia, most HBV patients acquire the virus perinatally or in early childhood and develop a life-long chronic infection [
1]. The mechanisms of vertical HBV transmission include intrauterine infection and transmission during delivery [
2]. For example, the prevalence of chronic HBV infection in the general population ranged 11–20% in Taiwan during 1980s [
3]. Approximately, 40% of HBV carriers were born to HBsAg-positive mothers and 85–95% of newborns with HBV exposure consequently had chronic infection [
4]. Thus, mother-to-child transmission (MTCT) during the perinatal period is the major transmission route of HBV in hyperendemic areas [
1]. Prevention of MTCT is thus the most important strategy to reduce the global burden of HBV infection. …