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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 5/2019

06.10.2018 | Original Article

Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts

verfasst von: Nashwan Al-Afifi, Aied Alabsi, Fahmi Kaid, Marina Bakri, Anand Ramanathan

Erschienen in: Clinical Oral Investigations | Ausgabe 5/2019

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Abstract

Objectives

In vivo study was performed to determine the chemopreventive efficacy of the DC resin methanol extract on a 4-nitroquinoline-1-oxide (4NQO) oral cancer animal model.

Materials and methods

This study involves administration of 4NQO solution for 8 weeks alone (cancer induction) or with Dracaena cinnabari (DC) extract at 100, 500, and 1000 mg/kg. DC extract administration started 1 week before exposure until 1 week after the carcinogen exposure was stopped. All rats were sacrificed after 22 weeks, and histological analysis was performed to assess any incidence of pathological changes. Immunohistochemical expressions of selected tumor marker antibodies were analyzed using an image analyzer computer system, and the expression of selected genes involved in apoptosis and proliferative mechanism related to oral cancer were evaluated using RT2-PCR.

Results

The incidence of OSCC decreased with the administration of DC extract at 100, 500, and 1000 mg/kg compared to the induced cancer group. The developed tumor was also observed to be smaller when compared to the induced cancer group. The DC 1000 mg/kg group inhibits the expression of Cyclin D1, Ki-67, Bcl-2, and p53 proteins. It was observed that DC 1000 mg/kg induced apoptosis by upregulation of Bax and Casp3 genes and downregulation of Tp53, Bcl-2, Cox-2, Cyclin D1, and EGFR genes when compared to the induced cancer group.

Conclusions

The data indicated that systemic administration of the DC resin methanol extract has anticarcinogenic potency on oral carcinogenesis.

Clinical relevance

Chemoprevention with DC resin methanol extract may significantly reduce morbidity and possibly mortality from OSCC.
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Metadaten
Titel
Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts
verfasst von
Nashwan Al-Afifi
Aied Alabsi
Fahmi Kaid
Marina Bakri
Anand Ramanathan
Publikationsdatum
06.10.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 5/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2685-6

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