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Erschienen in: Archives of Gynecology and Obstetrics 5/2019

14.02.2019 | Maternal-Fetal Medicine

Prevention of spontaneous preterm birth

verfasst von: George Daskalakis, Maria Goya, Vasilios Pergialiotis, Luis Cabero, Ioannis Kyvernitakis, Aris Antsaklis, Birgit Arabin

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2019

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Abstract

Background

It is estimated that globally, approximately 13 million preterm infants are born annually and a much higher number of pregnancies are characterized by threatening preterm birth.

Findings

A proportional inverse correlation between gestational age at delivery and neonatal mortality has been observed which is more prevalent in countries without high standard neonatal care. The socioeconomic burden of preterm birth is enormous, as preterm neonates are particularly prone to severe morbidity that may expand up to adulthood. Several strategies have been proposed for the prevention of preterm birth which can be sub-stratified as primary (when these apply to the general population), secondary (when they target women at risk), and tertiary (optimizing neonatal outcomes when preterm birth cannot any longer be prevented). The aim of this review is to summarize the most important strategies.
Literatur
1.
Zurück zum Zitat Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH et al (2010) The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 88(1):31–38CrossRefPubMed Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH et al (2010) The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 88(1):31–38CrossRefPubMed
2.
Zurück zum Zitat Steer P (2005) The epidemiology of preterm labour. BJOG Int J Obstet Gynaecol 112(Suppl 1):1–3 Steer P (2005) The epidemiology of preterm labour. BJOG Int J Obstet Gynaecol 112(Suppl 1):1–3
3.
Zurück zum Zitat Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379(9832):2162–2172CrossRefPubMed Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379(9832):2162–2172CrossRefPubMed
4.
Zurück zum Zitat Zeitlin J, Szamotulska K, Drewniak N, Mohangoo AD, Chalmers J, Sakkeus L et al (2013) Preterm birth time trends in Europe: a study of 19 countries. BJOG Int J Obstet Gynaecol 120(11):1356–1365CrossRef Zeitlin J, Szamotulska K, Drewniak N, Mohangoo AD, Chalmers J, Sakkeus L et al (2013) Preterm birth time trends in Europe: a study of 19 countries. BJOG Int J Obstet Gynaecol 120(11):1356–1365CrossRef
5.
Zurück zum Zitat Diez-Izquierdo A, Balaguer A, Lidon-Moyano C, Martin-Sanchez JC, Galan I, Fernandez E et al (2018) Correlation between tobacco control policies and preterm births and low birth weight in Europe. Environ Res 160:547–553CrossRefPubMed Diez-Izquierdo A, Balaguer A, Lidon-Moyano C, Martin-Sanchez JC, Galan I, Fernandez E et al (2018) Correlation between tobacco control policies and preterm births and low birth weight in Europe. Environ Res 160:547–553CrossRefPubMed
6.
Zurück zum Zitat Lawn JE, Cousens S, Zupan J (2005) 4 million neonatal deaths: when? Where? Why? Lancet (London, England) 365(9462):891–900CrossRef Lawn JE, Cousens S, Zupan J (2005) 4 million neonatal deaths: when? Where? Why? Lancet (London, England) 365(9462):891–900CrossRef
7.
Zurück zum Zitat Saigal S, Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet (London, England) 371(9608):261–269CrossRef Saigal S, Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet (London, England) 371(9608):261–269CrossRef
8.
Zurück zum Zitat Goldenberg RL, Culhane JF, Iams JD, Romero R (2008) Epidemiology and causes of preterm birth. Lancet (London, England) 371(9606):75–84CrossRef Goldenberg RL, Culhane JF, Iams JD, Romero R (2008) Epidemiology and causes of preterm birth. Lancet (London, England) 371(9606):75–84CrossRef
9.
Zurück zum Zitat Fuchs F, Monet B, Ducruet T, Chaillet N, Audibert F (2018) Effect of maternal age on the risk of preterm birth: a large cohort study. PLoS One. 13(1):e0191002-eCrossRef Fuchs F, Monet B, Ducruet T, Chaillet N, Audibert F (2018) Effect of maternal age on the risk of preterm birth: a large cohort study. PLoS One. 13(1):e0191002-eCrossRef
10.
Zurück zum Zitat Goisis A, Remes H, Barclay K, Martikainen P, Myrskyla M (2017) Advanced maternal age and the risk of low birth weight and preterm delivery: a within-family analysis using finnish population registers. Am J Epidemiol 186(11):1219–1226CrossRefPubMedPubMedCentral Goisis A, Remes H, Barclay K, Martikainen P, Myrskyla M (2017) Advanced maternal age and the risk of low birth weight and preterm delivery: a within-family analysis using finnish population registers. Am J Epidemiol 186(11):1219–1226CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Lucovnik M, Bregar AT, Steblovnik L, Verdenik I, Gersak K, Blickstein I et al (2016) Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study. J Perinat Med 44(5):505–509CrossRefPubMed Lucovnik M, Bregar AT, Steblovnik L, Verdenik I, Gersak K, Blickstein I et al (2016) Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study. J Perinat Med 44(5):505–509CrossRefPubMed
12.
Zurück zum Zitat Lisonkova S, Hutcheon JA, Joseph KS (2011) Temporal trends in neonatal outcomes following iatrogenic preterm delivery. BMC Pregnancy Childbirth 11:39CrossRefPubMedPubMedCentral Lisonkova S, Hutcheon JA, Joseph KS (2011) Temporal trends in neonatal outcomes following iatrogenic preterm delivery. BMC Pregnancy Childbirth 11:39CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Getahun D, Demissie K, Marcella SW, Rhoads GG (2014) The impact of changes in preterm birth among twins on stillbirth and infant mortality in the United States. J Perinatol Off J Calif Perinat Assoc 34(11):823–829 Getahun D, Demissie K, Marcella SW, Rhoads GG (2014) The impact of changes in preterm birth among twins on stillbirth and infant mortality in the United States. J Perinatol Off J Calif Perinat Assoc 34(11):823–829
15.
Zurück zum Zitat Shiono PH, Klebanoff MA, Rhoads GG (1986) Smoking and drinking during pregnancy. Their effects on preterm birth. JAMA 255(1):82–84CrossRefPubMed Shiono PH, Klebanoff MA, Rhoads GG (1986) Smoking and drinking during pregnancy. Their effects on preterm birth. JAMA 255(1):82–84CrossRefPubMed
16.
Zurück zum Zitat Cnattingius S, Forman MR, Berendes HW, Graubard BI, Isotalo L (1993) Effect of age, parity, and smoking on pregnancy outcome: a population-based study. Am J Obstet Gynecol 168(1 Pt 1):16–21CrossRefPubMed Cnattingius S, Forman MR, Berendes HW, Graubard BI, Isotalo L (1993) Effect of age, parity, and smoking on pregnancy outcome: a population-based study. Am J Obstet Gynecol 168(1 Pt 1):16–21CrossRefPubMed
17.
Zurück zum Zitat Harlow BL, Frigoletto FD, Cramer DW, Evans JK, LeFevre ML, Bain RP et al (1996) Determinants of preterm delivery in low-risk pregnancies. The RADIUS Study Group. J Clin Epidemiol 49(4):441–448CrossRefPubMed Harlow BL, Frigoletto FD, Cramer DW, Evans JK, LeFevre ML, Bain RP et al (1996) Determinants of preterm delivery in low-risk pregnancies. The RADIUS Study Group. J Clin Epidemiol 49(4):441–448CrossRefPubMed
18.
Zurück zum Zitat Kyrklund-Blomberg NB, Cnattingius S (1998) Preterm birth and maternal smoking: risks related to gestational age and onset of delivery. Am J Obstet Gynecol 179(4):1051–1055CrossRefPubMed Kyrklund-Blomberg NB, Cnattingius S (1998) Preterm birth and maternal smoking: risks related to gestational age and onset of delivery. Am J Obstet Gynecol 179(4):1051–1055CrossRefPubMed
19.
Zurück zum Zitat Been JV, Nurmatov UB, Cox B, Nawrot TS, van Schayck CP, Sheikh A (2015) Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Eur J Paediatr Dent Off J Eur Acad Paediatr Dent 16(3):210–211 Been JV, Nurmatov UB, Cox B, Nawrot TS, van Schayck CP, Sheikh A (2015) Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Eur J Paediatr Dent Off J Eur Acad Paediatr Dent 16(3):210–211
20.
Zurück zum Zitat Been JV, Nurmatov UB, Cox B, Nawrot TS, van Schayck CP, Sheikh A (2014) Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Lancet 383(9928):1549–1560CrossRefPubMed Been JV, Nurmatov UB, Cox B, Nawrot TS, van Schayck CP, Sheikh A (2014) Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Lancet 383(9928):1549–1560CrossRefPubMed
21.
Zurück zum Zitat Hiersch L, Rosen H, Okby R, Freeman H, Barrett J, Melamed N (2016) The greater risk of preterm birth in triplets is mirrored by a more rapid cervical shortening along gestation. Am J Obstet Gynecol 215(3):357.e1–357.e6CrossRef Hiersch L, Rosen H, Okby R, Freeman H, Barrett J, Melamed N (2016) The greater risk of preterm birth in triplets is mirrored by a more rapid cervical shortening along gestation. Am J Obstet Gynecol 215(3):357.e1–357.e6CrossRef
22.
Zurück zum Zitat Bebbington M (2014) Selective reduction in multiple gestations. Best Pract Res Clin Obstet Gynaecol 28(2):239–247CrossRefPubMed Bebbington M (2014) Selective reduction in multiple gestations. Best Pract Res Clin Obstet Gynaecol 28(2):239–247CrossRefPubMed
23.
Zurück zum Zitat Harbottle S, Hughes C, Cutting R, Roberts S, Brison D (2015) Elective single embryo transfer: an update to UK best practice guidelines. Hum Fertil (Cambridge, England) 18(3):165–183CrossRef Harbottle S, Hughes C, Cutting R, Roberts S, Brison D (2015) Elective single embryo transfer: an update to UK best practice guidelines. Hum Fertil (Cambridge, England) 18(3):165–183CrossRef
24.
Zurück zum Zitat Joint SOGC-CFAS (2008) Guidelines for the number of embryos to transfer following in vitro fertilization No. 182 September 2006. Int J Gynaecol Obstet 102(2):203–216CrossRef Joint SOGC-CFAS (2008) Guidelines for the number of embryos to transfer following in vitro fertilization No. 182 September 2006. Int J Gynaecol Obstet 102(2):203–216CrossRef
25.
Zurück zum Zitat Cavoretto P, Candiani M, Giorgione V, Inversetti A, Abu-Saba MM, Tiberio F et al (2018) Risk of spontaneous preterm birth in singleton pregnancies conceived after IVF/ICSI treatment: meta-analysis of cohort studies. Ultrasound Obstet Gynecol 51(1):43–53CrossRefPubMed Cavoretto P, Candiani M, Giorgione V, Inversetti A, Abu-Saba MM, Tiberio F et al (2018) Risk of spontaneous preterm birth in singleton pregnancies conceived after IVF/ICSI treatment: meta-analysis of cohort studies. Ultrasound Obstet Gynecol 51(1):43–53CrossRefPubMed
26.
Zurück zum Zitat Halliday-Bell JA, Quansah R, Gissler M, Jaakkola JJ (2010) Laboratory work and adverse pregnancy outcomes. Occup Med (Oxford, England) 60(4):310–313CrossRef Halliday-Bell JA, Quansah R, Gissler M, Jaakkola JJ (2010) Laboratory work and adverse pregnancy outcomes. Occup Med (Oxford, England) 60(4):310–313CrossRef
27.
Zurück zum Zitat Palmer KT, Bonzini M, Harris EC, Linaker C, Bonde JP (2013) Work activities and risk of prematurity, low birthweight and pre-eclampsia: an updated review with meta-analysis. Occup Environ Med 70(4):213–222CrossRefPubMed Palmer KT, Bonzini M, Harris EC, Linaker C, Bonde JP (2013) Work activities and risk of prematurity, low birthweight and pre-eclampsia: an updated review with meta-analysis. Occup Environ Med 70(4):213–222CrossRefPubMed
28.
Zurück zum Zitat Christiaens I, Hegadoren K, Olson DM (2015) Adverse childhood experiences are associated with spontaneous preterm birth: a case–control study. BMC Med 13:124CrossRefPubMedPubMedCentral Christiaens I, Hegadoren K, Olson DM (2015) Adverse childhood experiences are associated with spontaneous preterm birth: a case–control study. BMC Med 13:124CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Faraji J, Soltanpour N, Lotfi H, Moeeini R, Moharreri AR, Roudaki S et al (2017) Lack of social support raises stress vulnerability in rats with a history of ancestral stress. Sci Rep 7(1):5277CrossRefPubMedPubMedCentral Faraji J, Soltanpour N, Lotfi H, Moeeini R, Moharreri AR, Roudaki S et al (2017) Lack of social support raises stress vulnerability in rats with a history of ancestral stress. Sci Rep 7(1):5277CrossRefPubMedPubMedCentral
30.
31.
Zurück zum Zitat Mikkelsen TB, Osterdal ML, Knudsen VK, Haugen M, Meltzer HM, Bakketeig L et al (2008) Association between a Mediterranean-type diet and risk of preterm birth among Danish women: a prospective cohort study. Acta obstetricia et gynecologica Scandinavica 87(3):325–330CrossRefPubMed Mikkelsen TB, Osterdal ML, Knudsen VK, Haugen M, Meltzer HM, Bakketeig L et al (2008) Association between a Mediterranean-type diet and risk of preterm birth among Danish women: a prospective cohort study. Acta obstetricia et gynecologica Scandinavica 87(3):325–330CrossRefPubMed
32.
Zurück zum Zitat Parlapani E, Agakidis C, Karagiozoglou-Lampoudi T, Sarafidis K, Agakidou E, Athanasiadis A et al (2017) The Mediterranean diet adherence by pregnant women delivering prematurely: association with size at birth and complications of prematurity. J Maternal Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 32:1–8 Parlapani E, Agakidis C, Karagiozoglou-Lampoudi T, Sarafidis K, Agakidou E, Athanasiadis A et al (2017) The Mediterranean diet adherence by pregnant women delivering prematurely: association with size at birth and complications of prematurity. J Maternal Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 32:1–8
33.
Zurück zum Zitat Hegelund ER, Urhoj SK, Andersen AN, Mortensen LH (2018) Interpregnancy interval and risk of adverse pregnancy outcomes: a register-based study of 328,577 pregnancies in Denmark 1994–2010. Maternal Child Health J 22(7):1008–1015CrossRef Hegelund ER, Urhoj SK, Andersen AN, Mortensen LH (2018) Interpregnancy interval and risk of adverse pregnancy outcomes: a register-based study of 328,577 pregnancies in Denmark 1994–2010. Maternal Child Health J 22(7):1008–1015CrossRef
34.
Zurück zum Zitat Kuwahara M, Yamasato K, Tschann M, Kaneshiro B (2018) Interpregnancy interval and subsequent pregnancy outcomes after dilation and evacuation. J Obstet Gynaecol J Inst Obstet Gynaeco 38(4):516–520CrossRef Kuwahara M, Yamasato K, Tschann M, Kaneshiro B (2018) Interpregnancy interval and subsequent pregnancy outcomes after dilation and evacuation. J Obstet Gynaecol J Inst Obstet Gynaeco 38(4):516–520CrossRef
35.
Zurück zum Zitat Mannisto J, Bloigu A, Mentula M, Gissler M, Heikinheimo O, Niinimaki M (2017) Interpregnancy Interval after termination of pregnancy and the risks of adverse outcomes in subsequent birth. Obstet Gynecol 129(2):347–354CrossRefPubMed Mannisto J, Bloigu A, Mentula M, Gissler M, Heikinheimo O, Niinimaki M (2017) Interpregnancy Interval after termination of pregnancy and the risks of adverse outcomes in subsequent birth. Obstet Gynecol 129(2):347–354CrossRefPubMed
36.
Zurück zum Zitat Medley N, Vogel JP, Care A, Alfirevic Z (2018) Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 11:CD012505PubMed Medley N, Vogel JP, Care A, Alfirevic Z (2018) Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 11:CD012505PubMed
37.
Zurück zum Zitat Sotiriadis A, Papatheodorou S, Kavvadias A, Makrydimas G (2010) Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta-analysis. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 35(1):54–64CrossRef Sotiriadis A, Papatheodorou S, Kavvadias A, Makrydimas G (2010) Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta-analysis. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 35(1):54–64CrossRef
38.
Zurück zum Zitat Lim AC, Hegeman MA, HuisIn ‘T Veld MA, Opmeer BC, Bruinse HW, Mol BWJ (2011) Cervical length measurement for the prediction of preterm birth in multiple pregnancies: a systematic review and bivariate meta-analysis. Ultrasound Obstet Gynecol 38(1):10–17CrossRefPubMed Lim AC, Hegeman MA, HuisIn ‘T Veld MA, Opmeer BC, Bruinse HW, Mol BWJ (2011) Cervical length measurement for the prediction of preterm birth in multiple pregnancies: a systematic review and bivariate meta-analysis. Ultrasound Obstet Gynecol 38(1):10–17CrossRefPubMed
39.
Zurück zum Zitat Kyvernitakis I, Maul H, Bahlmann F (2018) Controversies about the secondary prevention of spontaneous preterm birth. Geburtshilfe und Frauenheilkunde 78(6):585–595CrossRefPubMedPubMedCentral Kyvernitakis I, Maul H, Bahlmann F (2018) Controversies about the secondary prevention of spontaneous preterm birth. Geburtshilfe und Frauenheilkunde 78(6):585–595CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Kyvernitakis I, Arabin B (2017) Re: Prevention of preterm birth with pessary in twins (PoPPT): a randomized controlled trial. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 50(3):408–409CrossRef Kyvernitakis I, Arabin B (2017) Re: Prevention of preterm birth with pessary in twins (PoPPT): a randomized controlled trial. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 50(3):408–409CrossRef
41.
Zurück zum Zitat Fanca MS HT, Hatanaka AR, Mattar R, Moron AF (2015) The importance of learning curve in practice of cervical pessary. In: 14th World Congress in Fetal Medicine; Crete, Greece Fanca MS HT, Hatanaka AR, Mattar R, Moron AF (2015) The importance of learning curve in practice of cervical pessary. In: 14th World Congress in Fetal Medicine; Crete, Greece
42.
Zurück zum Zitat Cannie MM, Dobrescu O, Gucciardo L, Strizek B, Ziane S, Sakkas E et al (2013) Arabin cervical pessary in women at high risk of preterm birth: a magnetic resonance imaging observational follow-up study. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 42(4):426–433 Cannie MM, Dobrescu O, Gucciardo L, Strizek B, Ziane S, Sakkas E et al (2013) Arabin cervical pessary in women at high risk of preterm birth: a magnetic resonance imaging observational follow-up study. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 42(4):426–433
43.
Zurück zum Zitat Mendoza M, Goya M, Gascon A, Pratcorona L, Merced C, Rodo C et al (2017) Modification of cervical length after cervical pessary insertion: correlation weeks of gestation. J Matern Fetal Neonat Med 30(13):1596–1601CrossRef Mendoza M, Goya M, Gascon A, Pratcorona L, Merced C, Rodo C et al (2017) Modification of cervical length after cervical pessary insertion: correlation weeks of gestation. J Matern Fetal Neonat Med 30(13):1596–1601CrossRef
44.
Zurück zum Zitat Arabin B, Halbesma JR, Vork F, Hubener M, van Eyck J (2003) Is treatment with vaginal pessaries an option in patients with a sonographically detected short cervix? J Perinat Med 31(2):122–133CrossRefPubMed Arabin B, Halbesma JR, Vork F, Hubener M, van Eyck J (2003) Is treatment with vaginal pessaries an option in patients with a sonographically detected short cervix? J Perinat Med 31(2):122–133CrossRefPubMed
45.
Zurück zum Zitat Nicolaides KH, Syngelaki A, Poon LC, Picciarelli G, Tul N, Zamprakou A et al (2016) A randomized trial of a cervical pessary to prevent preterm singleton birth. N Engl J Med 374(11):1044–1052CrossRefPubMed Nicolaides KH, Syngelaki A, Poon LC, Picciarelli G, Tul N, Zamprakou A et al (2016) A randomized trial of a cervical pessary to prevent preterm singleton birth. N Engl J Med 374(11):1044–1052CrossRefPubMed
46.
Zurück zum Zitat Goya M, Pratcorona L, Higueras T, Perez-Hoyos S, Carreras E, Cabero L (2011) Sonographic cervical length measurement in pregnant women with a cervical pessary. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 38(2):205–209CrossRef Goya M, Pratcorona L, Higueras T, Perez-Hoyos S, Carreras E, Cabero L (2011) Sonographic cervical length measurement in pregnant women with a cervical pessary. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 38(2):205–209CrossRef
47.
Zurück zum Zitat Saccone G, Maruotti GM, Giudicepietro A, Martinelli P, Italian Preterm Birth Prevention Working G (2017) Effect of cervical pessary on spontaneous preterm birth in women with singleton pregnancies and short cervical length: a randomized clinical trial. JAMA J Am Med Assoc 318(23):2317–2324CrossRef Saccone G, Maruotti GM, Giudicepietro A, Martinelli P, Italian Preterm Birth Prevention Working G (2017) Effect of cervical pessary on spontaneous preterm birth in women with singleton pregnancies and short cervical length: a randomized clinical trial. JAMA J Am Med Assoc 318(23):2317–2324CrossRef
48.
Zurück zum Zitat Hui SY, Chor CM, Lau TK, Lao TT, Leung TY (2012) Cerclage pessary for preventing preterm birth in women with a singleton pregnancy and a short cervix at 20 to 24 weeks: a randomized controlled trial. Am J Perinatol 30:283–288CrossRefPubMed Hui SY, Chor CM, Lau TK, Lao TT, Leung TY (2012) Cerclage pessary for preventing preterm birth in women with a singleton pregnancy and a short cervix at 20 to 24 weeks: a randomized controlled trial. Am J Perinatol 30:283–288CrossRefPubMed
49.
Zurück zum Zitat Karbasian N, Sheikh M, Pirjani R, Hazrati S, Tara F, Hantoushzadeh S (2016) Combined treatment with cervical pessary and vaginal progesterone for the prevention of preterm birth: a randomized clinical trial. J Obstet Gynaecol Res 42(12):1673–1679CrossRefPubMed Karbasian N, Sheikh M, Pirjani R, Hazrati S, Tara F, Hantoushzadeh S (2016) Combined treatment with cervical pessary and vaginal progesterone for the prevention of preterm birth: a randomized clinical trial. J Obstet Gynaecol Res 42(12):1673–1679CrossRefPubMed
50.
Zurück zum Zitat Dugoff L, Berghella V, Sehdev H, Mackeen AD, Goetzl L, Ludmir J (2018) Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial. Ultrasound Obstet Gynecol 51(5):573–579CrossRefPubMed Dugoff L, Berghella V, Sehdev H, Mackeen AD, Goetzl L, Ludmir J (2018) Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial. Ultrasound Obstet Gynecol 51(5):573–579CrossRefPubMed
51.
Zurück zum Zitat Melcer Y, Kovo M, Maymon R, Bar J, Wiener I, Neeman O et al (2019) Arabin cervical pessary with vaginal progesterone versus vaginal progesterone for preventing preterm delivery. J Matern Fetal Neonat Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 2019:1–131 Melcer Y, Kovo M, Maymon R, Bar J, Wiener I, Neeman O et al (2019) Arabin cervical pessary with vaginal progesterone versus vaginal progesterone for preventing preterm delivery. J Matern Fetal Neonat Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 2019:1–131
52.
Zurück zum Zitat Pratcorona L, Goya M, Merced C, Rodo C, Llurba E, Higueras T et al (2018) Cervical pessary to reduce preterm birth <34 weeks of gestation after an episode of preterm labor and a short cervix: a randomized controlled trial. Am J Obstet Gynecol 219(1):99e1–99e16CrossRef Pratcorona L, Goya M, Merced C, Rodo C, Llurba E, Higueras T et al (2018) Cervical pessary to reduce preterm birth <34 weeks of gestation after an episode of preterm labor and a short cervix: a randomized controlled trial. Am J Obstet Gynecol 219(1):99e1–99e16CrossRef
53.
Zurück zum Zitat Hermans FJR, Schuit E, Bekker MN, Woiski M, de Boer MA, Sueters M et al (2018) Cervical pessary after arrested preterm labor: a randomized controlled trial. Obstet Gynecol 132(3):741–749CrossRefPubMed Hermans FJR, Schuit E, Bekker MN, Woiski M, de Boer MA, Sueters M et al (2018) Cervical pessary after arrested preterm labor: a randomized controlled trial. Obstet Gynecol 132(3):741–749CrossRefPubMed
54.
Zurück zum Zitat Care A, Muller-Myhsok B, Olearo E, Todros T, Caradeux J, Goya M et al (2018) Can previous preterm birth classification influence treatment of short cervix in a subsequent pregnancy? Comparison of vaginal progesterone and Arabin pessary. Ultrasound Obstet Gynecol. https://doi.org/10.1002/uog.19118 CrossRef Care A, Muller-Myhsok B, Olearo E, Todros T, Caradeux J, Goya M et al (2018) Can previous preterm birth classification influence treatment of short cervix in a subsequent pregnancy? Comparison of vaginal progesterone and Arabin pessary. Ultrasound Obstet Gynecol. https://​doi.​org/​10.​1002/​uog.​19118 CrossRef
55.
Zurück zum Zitat Liem S, Schuit E, Hegeman M, Bais J, de Boer K, Bloemenkamp K et al (2013) Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial. Lancet (London, England) 382(9901):1341–1349CrossRef Liem S, Schuit E, Hegeman M, Bais J, de Boer K, Bloemenkamp K et al (2013) Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial. Lancet (London, England) 382(9901):1341–1349CrossRef
56.
Zurück zum Zitat Goya M, de la Calle M, Pratcorona L, Merced C, Rodo C, Munoz B et al (2016) Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol 214(2):145–152CrossRefPubMed Goya M, de la Calle M, Pratcorona L, Merced C, Rodo C, Munoz B et al (2016) Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol 214(2):145–152CrossRefPubMed
57.
Zurück zum Zitat Fox NS, Gupta S, Lam-Rachlin J, Rebarber A, Klauser CK, Saltzman DH (2016) Cervical pessary and vaginal progesterone in twin pregnancies with a short cervix. Obstet Gynecol 127(4):625–630CrossRefPubMed Fox NS, Gupta S, Lam-Rachlin J, Rebarber A, Klauser CK, Saltzman DH (2016) Cervical pessary and vaginal progesterone in twin pregnancies with a short cervix. Obstet Gynecol 127(4):625–630CrossRefPubMed
58.
Zurück zum Zitat Nicolaides KH, Syngelaki A, Poon LC, de Paco Matallana C, Plasencia W, Molina FS et al (2016) Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial. Am J Obstet Gynecol 214(1):3.e1–3.e9CrossRef Nicolaides KH, Syngelaki A, Poon LC, de Paco Matallana C, Plasencia W, Molina FS et al (2016) Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial. Am J Obstet Gynecol 214(1):3.e1–3.e9CrossRef
60.
Zurück zum Zitat Liem SM, Schuit E, van Pampus MG, van Melick M, Monfrance M, Langenveld J et al (2016) Cervical pessaries to prevent preterm birth in women with a multiple pregnancy: a per-protocol analysis of a randomized clinical trial. Acta Obstet Gynecol Scand 95(4):444–451CrossRefPubMed Liem SM, Schuit E, van Pampus MG, van Melick M, Monfrance M, Langenveld J et al (2016) Cervical pessaries to prevent preterm birth in women with a multiple pregnancy: a per-protocol analysis of a randomized clinical trial. Acta Obstet Gynecol Scand 95(4):444–451CrossRefPubMed
61.
Zurück zum Zitat van’t Hooft J, van der Lee JH, Opmeer BC, van Wassenaer-Leemhuis AG, van Baar AL, Bekedam DJ et al (2018) Pessary for prevention of preterm birth in twin pregnancy with short cervix: 3-year follow-up study. Ultrasound Obstet Gynecol 51(5):621–628CrossRef van’t Hooft J, van der Lee JH, Opmeer BC, van Wassenaer-Leemhuis AG, van Baar AL, Bekedam DJ et al (2018) Pessary for prevention of preterm birth in twin pregnancy with short cervix: 3-year follow-up study. Ultrasound Obstet Gynecol 51(5):621–628CrossRef
62.
Zurück zum Zitat Papiernik-Berkhauer E (1970) Etude en double aveugle d’un medicament prevenant la survenue prematur´ee de l’accouchement chez des femmes ‘a risque eleve’ d’accouchement premature. Edition Schering IV(3):65–68 Papiernik-Berkhauer E (1970) Etude en double aveugle d’un medicament prevenant la survenue prematur´ee de l’accouchement chez des femmes ‘a risque eleve’ d’accouchement premature. Edition Schering IV(3):65–68
63.
Zurück zum Zitat Keirse MJ (1990) Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynaecol 97(2):149–154CrossRefPubMed Keirse MJ (1990) Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynaecol 97(2):149–154CrossRefPubMed
64.
Zurück zum Zitat Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH et al (2003) Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348(24):2379–2385CrossRefPubMed Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH et al (2003) Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348(24):2379–2385CrossRefPubMed
65.
Zurück zum Zitat Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH (2007) Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 357(5):462–469CrossRefPubMed Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH (2007) Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 357(5):462–469CrossRefPubMed
66.
Zurück zum Zitat Romero R, Stanczyk FZ (2013) Progesterone is not the same as 17alpha-hydroxyprogesterone caproate: implications for obstetrical practice. Am J Obstet Gynecol 208(6):421–426CrossRefPubMed Romero R, Stanczyk FZ (2013) Progesterone is not the same as 17alpha-hydroxyprogesterone caproate: implications for obstetrical practice. Am J Obstet Gynecol 208(6):421–426CrossRefPubMed
67.
Zurück zum Zitat Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M et al (2011) Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 38(1):18–31CrossRefPubMedPubMedCentral Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M et al (2011) Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 38(1):18–31CrossRefPubMedPubMedCentral
68.
Zurück zum Zitat FDA (2012) Background document for meeting of advisory committee for reproductive health drugs. Research Cfdea, ed White paper, confidential FDA FDA (2012) Background document for meeting of advisory committee for reproductive health drugs. Research Cfdea, ed White paper, confidential FDA
69.
Zurück zum Zitat Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S et al (2016) Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 387(10033):2106–2116CrossRefPubMedPubMedCentral Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S et al (2016) Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 387(10033):2106–2116CrossRefPubMedPubMedCentral
70.
Zurück zum Zitat Romero R, Conde-Agudelo A, Da Fonseca E, O’Brien JM, Cetingoz E, Creasy GW et al (2018) Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data. Am J Obstet Gynecol 218(2):161–180CrossRefPubMed Romero R, Conde-Agudelo A, Da Fonseca E, O’Brien JM, Cetingoz E, Creasy GW et al (2018) Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data. Am J Obstet Gynecol 218(2):161–180CrossRefPubMed
71.
Zurück zum Zitat Waters TP, Schultz BA, Mercer BM, Catalano PM (2009) Effect of 17alpha-hydroxyprogesterone caproate on glucose intolerance in pregnancy. Obstet Gynecol 114(1):45–49CrossRefPubMed Waters TP, Schultz BA, Mercer BM, Catalano PM (2009) Effect of 17alpha-hydroxyprogesterone caproate on glucose intolerance in pregnancy. Obstet Gynecol 114(1):45–49CrossRefPubMed
72.
Zurück zum Zitat Rebarber A, Istwan NB, Russo-Stieglitz K, Cleary-Goldman J, Rhea DJ, Stanziano GJ et al (2007) Increased incidence of gestational diabetes in women receiving prophylactic 17alpha-hydroxyprogesterone caproate for prevention of recurrent preterm delivery. Diabetes Care 30(9):2277–2280CrossRefPubMed Rebarber A, Istwan NB, Russo-Stieglitz K, Cleary-Goldman J, Rhea DJ, Stanziano GJ et al (2007) Increased incidence of gestational diabetes in women receiving prophylactic 17alpha-hydroxyprogesterone caproate for prevention of recurrent preterm delivery. Diabetes Care 30(9):2277–2280CrossRefPubMed
73.
Zurück zum Zitat Gyamfi C, Horton AL, Momirova V, Rouse DJ, Caritis SN, Peaceman AM et al (2009) The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies. Am J Obstet Gynecol 201(4):392e1-5CrossRef Gyamfi C, Horton AL, Momirova V, Rouse DJ, Caritis SN, Peaceman AM et al (2009) The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies. Am J Obstet Gynecol 201(4):392e1-5CrossRef
74.
Zurück zum Zitat Prior M, Hibberd R, Asemota N, Thornton JG (2017) Inadvertent P-hacking among trials and systematic reviews of the effect of progestogens in pregnancy? A systematic review and meta-analysis. BJOG Int J Obstet Gynaecol 124(7):1008–1015CrossRef Prior M, Hibberd R, Asemota N, Thornton JG (2017) Inadvertent P-hacking among trials and systematic reviews of the effect of progestogens in pregnancy? A systematic review and meta-analysis. BJOG Int J Obstet Gynaecol 124(7):1008–1015CrossRef
75.
Zurück zum Zitat Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper S et al (2009) Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet 373(9680):2034–2040CrossRefPubMed Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper S et al (2009) Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet 373(9680):2034–2040CrossRefPubMed
76.
Zurück zum Zitat Brizot ML, Hernandez W, Liao AW, Bittar RE, Francisco RPV, Krebs VLJ et al (2015) Vaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol 213(1):82e1–82e9CrossRef Brizot ML, Hernandez W, Liao AW, Bittar RE, Francisco RPV, Krebs VLJ et al (2015) Vaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol 213(1):82e1–82e9CrossRef
77.
Zurück zum Zitat Rode L, Klein K, Nicolaides KH, Krampl-Bettelheim E, Tabor A, Group P (2011) Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 38(3):272–280CrossRef Rode L, Klein K, Nicolaides KH, Krampl-Bettelheim E, Tabor A, Group P (2011) Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 38(3):272–280CrossRef
78.
Zurück zum Zitat Serra V, Perales A, Meseguer J, Parrilla JJ, Lara C, Bellver J et al (2013) Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial. BJOG Int J Obstet Gynaecol 120(1):50–57CrossRef Serra V, Perales A, Meseguer J, Parrilla JJ, Lara C, Bellver J et al (2013) Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial. BJOG Int J Obstet Gynaecol 120(1):50–57CrossRef
79.
Zurück zum Zitat Schuit E, Stock S, Rode L, Rouse DJ, Lim AC, Norman JE et al (2015) Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG Int J Obstet Gynaecol 122(1):27–37CrossRef Schuit E, Stock S, Rode L, Rouse DJ, Lim AC, Norman JE et al (2015) Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG Int J Obstet Gynaecol 122(1):27–37CrossRef
80.
Zurück zum Zitat Dodd JM, Grivell RM, Ob CM, Dowswell T, Deussen AR (2017) Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database Syst Rev 10:CD012024PubMed Dodd JM, Grivell RM, Ob CM, Dowswell T, Deussen AR (2017) Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database Syst Rev 10:CD012024PubMed
81.
Zurück zum Zitat Romero R, Conde-Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E et al (2017) Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet Gynecol 49(3):303–314CrossRefPubMedPubMedCentral Romero R, Conde-Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E et al (2017) Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet Gynecol 49(3):303–314CrossRefPubMedPubMedCentral
82.
Zurück zum Zitat Boelig RC, Berghella V (2017) Current options for mechanical prevention of preterm birth. Semin Perinatol 41(8):452–460CrossRefPubMed Boelig RC, Berghella V (2017) Current options for mechanical prevention of preterm birth. Semin Perinatol 41(8):452–460CrossRefPubMed
83.
Zurück zum Zitat Hargreave M, Jensen A, Nielsen TS, Colov EP, Andersen KK, Pinborg A et al (2015) Maternal use of fertility drugs and risk of cancer in children—a nationwide population-based cohort study in Denmark. Int J Cancer (Journal international du cancer) 136(8):1931–1939CrossRef Hargreave M, Jensen A, Nielsen TS, Colov EP, Andersen KK, Pinborg A et al (2015) Maternal use of fertility drugs and risk of cancer in children—a nationwide population-based cohort study in Denmark. Int J Cancer (Journal international du cancer) 136(8):1931–1939CrossRef
84.
Zurück zum Zitat Jorgensen AL, Alfirevic Z, Tudur Smith C, Williamson PR (2007) Cervical stitch (cerclage) for preventing pregnancy loss: individual patient data meta-analysis. BJOG Int J Obstet Gynaecol 114(12):1460–1476CrossRef Jorgensen AL, Alfirevic Z, Tudur Smith C, Williamson PR (2007) Cervical stitch (cerclage) for preventing pregnancy loss: individual patient data meta-analysis. BJOG Int J Obstet Gynaecol 114(12):1460–1476CrossRef
85.
Zurück zum Zitat Odibo AO, Berghella V, To MS, Rust OA, Althuisius SM, Nicolaides KH (2007) Shirodkar versus McDonald cerclage for the prevention of preterm birth in women with short cervical length. Am J Perinatol 24(1):55–60CrossRefPubMed Odibo AO, Berghella V, To MS, Rust OA, Althuisius SM, Nicolaides KH (2007) Shirodkar versus McDonald cerclage for the prevention of preterm birth in women with short cervical length. Am J Perinatol 24(1):55–60CrossRefPubMed
86.
Zurück zum Zitat Pergialiotis V, Vlachos DG, Prodromidou A, Perrea D, Gkioka E, Vlachos GD (2015) Double versus single cervical cerclage for the prevention of preterm births. J Maternal Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 28(4):379–385 Pergialiotis V, Vlachos DG, Prodromidou A, Perrea D, Gkioka E, Vlachos GD (2015) Double versus single cervical cerclage for the prevention of preterm births. J Maternal Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 28(4):379–385
87.
Zurück zum Zitat Lotgering FK, Gaugler-Senden IP, Lotgering SF, Wallenburg HC (2006) Outcome after transabdominal cervicoisthmic cerclage. Obstet Gynecol 107(4):779–784CrossRefPubMed Lotgering FK, Gaugler-Senden IP, Lotgering SF, Wallenburg HC (2006) Outcome after transabdominal cervicoisthmic cerclage. Obstet Gynecol 107(4):779–784CrossRefPubMed
88.
Zurück zum Zitat Alfirevic Z, Stampalija T, Roberts D, Jorgensen AL (2012) Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev 4:CD008991 Alfirevic Z, Stampalija T, Roberts D, Jorgensen AL (2012) Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev 4:CD008991
89.
Zurück zum Zitat Rafael TJ, Berghella V, Alfirevic Z (2014) Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy. Cochrane Database Syst Rev 9:CD009166 Rafael TJ, Berghella V, Alfirevic Z (2014) Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy. Cochrane Database Syst Rev 9:CD009166
90.
Zurück zum Zitat Saccone G, Rust O, Althuisius S, Roman A, Berghella V (2015) Cerclage for short cervix in twin pregnancies: systematic review and meta-analysis of randomized trials using individual patient-level data. Acta obstetricia et gynecologica Scandinavica 94(4):352–358CrossRefPubMed Saccone G, Rust O, Althuisius S, Roman A, Berghella V (2015) Cerclage for short cervix in twin pregnancies: systematic review and meta-analysis of randomized trials using individual patient-level data. Acta obstetricia et gynecologica Scandinavica 94(4):352–358CrossRefPubMed
91.
Zurück zum Zitat Gueant JL, Daval JL, Vert P, Nicolas JP (2012) Folates and fetal programming: role of epigenetics and epigenomics. Bulletin de l’Academie nationale de medecine 196(9):1829–1842CrossRefPubMed Gueant JL, Daval JL, Vert P, Nicolas JP (2012) Folates and fetal programming: role of epigenetics and epigenomics. Bulletin de l’Academie nationale de medecine 196(9):1829–1842CrossRefPubMed
92.
Zurück zum Zitat Alfirevic Z, Owen J, Carreras Moratonas E, Sharp AN, Szychowski JM, Goya M (2013) Vaginal progesterone, cerclage or cervical pessary for preventing preterm birth in asymptomatic singleton pregnant women with a history of preterm birth and a sonographic short cervix. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 41(2):146–151CrossRef Alfirevic Z, Owen J, Carreras Moratonas E, Sharp AN, Szychowski JM, Goya M (2013) Vaginal progesterone, cerclage or cervical pessary for preventing preterm birth in asymptomatic singleton pregnant women with a history of preterm birth and a sonographic short cervix. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 41(2):146–151CrossRef
93.
Zurück zum Zitat Conde-Agudelo A, Romero R, Da Fonseca E, O’Brien JM, Cetingoz E, Creasy GW et al (2018) Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis. Am J Obstet Gynecol 219(1):10–25CrossRefPubMedPubMedCentral Conde-Agudelo A, Romero R, Da Fonseca E, O’Brien JM, Cetingoz E, Creasy GW et al (2018) Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis. Am J Obstet Gynecol 219(1):10–25CrossRefPubMedPubMedCentral
94.
Zurück zum Zitat Jarde A, Lutsiv O, Park CK, Beyene J, Dodd JM, Barrett J et al (2017) Effectiveness of progesterone, cerclage and pessary for preventing preterm birth in singleton pregnancies: a systematic review and network meta-analysis. BJOG Int J Obstet Gynaecol 124(8):1176–1189CrossRef Jarde A, Lutsiv O, Park CK, Beyene J, Dodd JM, Barrett J et al (2017) Effectiveness of progesterone, cerclage and pessary for preventing preterm birth in singleton pregnancies: a systematic review and network meta-analysis. BJOG Int J Obstet Gynaecol 124(8):1176–1189CrossRef
95.
Zurück zum Zitat Hezelgrave NL, Watson HA, Ridout A, Diab F, Seed PT, Chin-Smith E et al (2016) Rationale and design of SuPPoRT: a multi-centre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix. BMC Pregnancy Childbirth 16(1):358CrossRefPubMedPubMedCentral Hezelgrave NL, Watson HA, Ridout A, Diab F, Seed PT, Chin-Smith E et al (2016) Rationale and design of SuPPoRT: a multi-centre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix. BMC Pregnancy Childbirth 16(1):358CrossRefPubMedPubMedCentral
96.
Zurück zum Zitat Cruz-Melguizo S, San-Frutos L, Martinez-Payo C, Ruiz-Antoran B, Adiego-Burgos B, Campillos-Maza JM et al (2018) Cervical pessary compared with vaginal progesterone for preventing early preterm birth: a randomized controlled trial. Obstet Gynecol 132(4):907–915CrossRefPubMed Cruz-Melguizo S, San-Frutos L, Martinez-Payo C, Ruiz-Antoran B, Adiego-Burgos B, Campillos-Maza JM et al (2018) Cervical pessary compared with vaginal progesterone for preventing early preterm birth: a randomized controlled trial. Obstet Gynecol 132(4):907–915CrossRefPubMed
97.
Zurück zum Zitat Dang VQ, Nguyen LK, He YTN, Vu KN, Phan MTN, Pham TD, Vuong LTN, Le TQ, Mol BW (2018) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix < 38 mm: a randomized controlled trial. Am J Obstet Gynecol (suppl. 1):S603 Dang VQ, Nguyen LK, He YTN, Vu KN, Phan MTN, Pham TD, Vuong LTN, Le TQ, Mol BW (2018) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix < 38 mm: a randomized controlled trial. Am J Obstet Gynecol (suppl. 1):S603
98.
Zurück zum Zitat Dang VQ, Nguyen LK, He YT, Vu KN, Phan MT, Pham TD, et al eds (2018) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix <38 mm: a randomized controlled trial. SMFM 2018; Dallas Dang VQ, Nguyen LK, He YT, Vu KN, Phan MT, Pham TD, et al eds (2018) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix <38 mm: a randomized controlled trial. SMFM 2018; Dallas
99.
Zurück zum Zitat Dang VQ (2019) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix <38 mm: a randomized controlled trial. Obstet Gynecol Dang VQ (2019) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix <38 mm: a randomized controlled trial. Obstet Gynecol
100.
Zurück zum Zitat Boelig RC, Hecht N, Berghella V (2018) 698: Cervical length < 15 mm is the most important risk factor for early preterm birth in women with short cervix treated with vaginal progesterone. Am J Obstet Gynecol 218(1):S419–S420CrossRef Boelig RC, Hecht N, Berghella V (2018) 698: Cervical length < 15 mm is the most important risk factor for early preterm birth in women with short cervix treated with vaginal progesterone. Am J Obstet Gynecol 218(1):S419–S420CrossRef
101.
Zurück zum Zitat Enakpene CA, DiGiovanni L, Jones TN, Marshalla M, Mastrogiannis D (2018) Della Torre M (2018) Cervical cerclage for singleton pregnant patients on vaginal progesterone with progressive cervical shortening. Am J Obstet Gynecol 219(4):397e1–397e10CrossRef Enakpene CA, DiGiovanni L, Jones TN, Marshalla M, Mastrogiannis D (2018) Della Torre M (2018) Cervical cerclage for singleton pregnant patients on vaginal progesterone with progressive cervical shortening. Am J Obstet Gynecol 219(4):397e1–397e10CrossRef
102.
Zurück zum Zitat Wolnicki GB, Wedel F, Mouzakiti N, Al Naimi A, Herzeg A, Bahlmann F et al (2019) Combined treatment of McDonald cerclage and Arabin-pessary: a chance in the prevention of spontaneous preterm birth? J Maternal Fetal Neonatal Med 23:1–9CrossRef Wolnicki GB, Wedel F, Mouzakiti N, Al Naimi A, Herzeg A, Bahlmann F et al (2019) Combined treatment of McDonald cerclage and Arabin-pessary: a chance in the prevention of spontaneous preterm birth? J Maternal Fetal Neonatal Med 23:1–9CrossRef
103.
Zurück zum Zitat Mourad M, Qin S, Ananth CV, Fu A, Yoshida K, Myers K et al (2017) Human cervical smooth muscle stretch increases pro-inflammatory cytocine secretion. Am J Obstet Gynecol 2017(Suppl 1):109 Mourad M, Qin S, Ananth CV, Fu A, Yoshida K, Myers K et al (2017) Human cervical smooth muscle stretch increases pro-inflammatory cytocine secretion. Am J Obstet Gynecol 2017(Suppl 1):109
104.
Zurück zum Zitat Piso B, Zechmeister-Koss I, Winkler R (2014) Antenatal interventions to reduce preterm birth: an overview of cochrane systematic reviews. BMC Res Notes 7:265CrossRefPubMedPubMedCentral Piso B, Zechmeister-Koss I, Winkler R (2014) Antenatal interventions to reduce preterm birth: an overview of cochrane systematic reviews. BMC Res Notes 7:265CrossRefPubMedPubMedCentral
105.
Zurück zum Zitat Carr DB, Clark AL, Kernek K, Spinnato JA (1999) Maintenance oral nifedipine for preterm labor: a randomized clinical trial. Am J Obstet Gynecol 181(4):822–827CrossRefPubMed Carr DB, Clark AL, Kernek K, Spinnato JA (1999) Maintenance oral nifedipine for preterm labor: a randomized clinical trial. Am J Obstet Gynecol 181(4):822–827CrossRefPubMed
106.
Zurück zum Zitat Parry E, Roos C, Stone P, Hayward L, Mol BW, McCowan L (2014) The NIFTY study: a multicentre randomised double-blind placebo-controlled trial of nifedipine maintenance tocolysis in fetal fibronectin-positive women in threatened preterm labour. Aust N Z J obstet Gynaecol 54(3):231–236CrossRefPubMed Parry E, Roos C, Stone P, Hayward L, Mol BW, McCowan L (2014) The NIFTY study: a multicentre randomised double-blind placebo-controlled trial of nifedipine maintenance tocolysis in fetal fibronectin-positive women in threatened preterm labour. Aust N Z J obstet Gynaecol 54(3):231–236CrossRefPubMed
107.
Zurück zum Zitat Roos C, Spaanderman ME, Schuit E, Bloemenkamp KW, Bolte AC, Cornette J et al (2013) Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial. JAMA 309(1):41–47CrossRefPubMed Roos C, Spaanderman ME, Schuit E, Bloemenkamp KW, Bolte AC, Cornette J et al (2013) Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial. JAMA 309(1):41–47CrossRefPubMed
108.
Zurück zum Zitat Rozenberg P, Chauveaud A, Deruelle P, Capelle M, Winer N, Desbriere R et al (2012) Prevention of preterm delivery after successful tocolysis in preterm labor by 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Am J Obstet Gynecol 206(3):206e1–206e9CrossRef Rozenberg P, Chauveaud A, Deruelle P, Capelle M, Winer N, Desbriere R et al (2012) Prevention of preterm delivery after successful tocolysis in preterm labor by 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Am J Obstet Gynecol 206(3):206e1–206e9CrossRef
109.
Zurück zum Zitat Palacio M, Ronzoni S, Sanchez-Ramos L, Murphy KE (2016) Progestogens as maintenance treatment in arrested preterm labor: a systematic review and meta-analysis. Obstet Gynecol 128(5):989–1000CrossRefPubMed Palacio M, Ronzoni S, Sanchez-Ramos L, Murphy KE (2016) Progestogens as maintenance treatment in arrested preterm labor: a systematic review and meta-analysis. Obstet Gynecol 128(5):989–1000CrossRefPubMed
110.
Zurück zum Zitat Valenzuela GJ, Sanchez-Ramos L, Romero R, Silver HM, Koltun WD, Millar L et al (2000) Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. The Atosiban PTL-098 Study Group. Am J Obstet Gynecol 182(5):1184–1190CrossRefPubMed Valenzuela GJ, Sanchez-Ramos L, Romero R, Silver HM, Koltun WD, Millar L et al (2000) Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. The Atosiban PTL-098 Study Group. Am J Obstet Gynecol 182(5):1184–1190CrossRefPubMed
111.
Zurück zum Zitat Andrews WW, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A et al (2000) The preterm prediction study: association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 183(3):662–668CrossRefPubMed Andrews WW, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A et al (2000) The preterm prediction study: association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 183(3):662–668CrossRefPubMed
112.
Zurück zum Zitat Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA et al (2008) The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. American journal of obstetrics and gynecology. 198(1):43e1–43e5CrossRef Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA et al (2008) The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. American journal of obstetrics and gynecology. 198(1):43e1–43e5CrossRef
113.
Zurück zum Zitat Lamont RF, Sobel JD, Akins RA, Hassan SS, Chaiworapongsa T, Kusanovic JP et al (2011) The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG Int J Obstet Gynaecol 118(5):533–549CrossRef Lamont RF, Sobel JD, Akins RA, Hassan SS, Chaiworapongsa T, Kusanovic JP et al (2011) The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG Int J Obstet Gynaecol 118(5):533–549CrossRef
114.
Zurück zum Zitat Sierra LJ, Brown AG, Barila GO, Anton L, Barnum CE, Shetye SS et al (2018) Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice. PLoS One 13(1):e0191524CrossRefPubMedPubMedCentral Sierra LJ, Brown AG, Barila GO, Anton L, Barnum CE, Shetye SS et al (2018) Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice. PLoS One 13(1):e0191524CrossRefPubMedPubMedCentral
115.
Zurück zum Zitat Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P (2003) Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol 188(3):752–758CrossRefPubMed Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P (2003) Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol 188(3):752–758CrossRefPubMed
116.
Zurück zum Zitat Simcox R, Sin WT, Seed PT, Briley A, Shennan AH (2007) Prophylactic antibiotics for the prevention of preterm birth in women at risk: a meta-analysis. Aust N Z J Obstet Gynaecol 47(5):368–377CrossRefPubMed Simcox R, Sin WT, Seed PT, Briley A, Shennan AH (2007) Prophylactic antibiotics for the prevention of preterm birth in women at risk: a meta-analysis. Aust N Z J Obstet Gynaecol 47(5):368–377CrossRefPubMed
117.
Zurück zum Zitat Kenyon S, Pike K, Jones DR, Brocklehurst P, Marlow N, Salt A et al (2008) Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 372(9646):1319–1327CrossRefPubMed Kenyon S, Pike K, Jones DR, Brocklehurst P, Marlow N, Salt A et al (2008) Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 372(9646):1319–1327CrossRefPubMed
118.
Zurück zum Zitat Boggess KA (2010) Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol 202(2):101–102CrossRefPubMed Boggess KA (2010) Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol 202(2):101–102CrossRefPubMed
119.
Zurück zum Zitat Jeffcoat M, Parry S, Gerlach RW, Doyle MJ (2011) Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population. Am J Obstet Gynecol 205(4):382e1–382e6CrossRef Jeffcoat M, Parry S, Gerlach RW, Doyle MJ (2011) Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population. Am J Obstet Gynecol 205(4):382e1–382e6CrossRef
120.
Zurück zum Zitat Jiang H, Xiong X, Buekens P, Su Y, Qian X (2015) Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial. BMC Pregnancy Childbirth 15:311CrossRefPubMedPubMedCentral Jiang H, Xiong X, Buekens P, Su Y, Qian X (2015) Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial. BMC Pregnancy Childbirth 15:311CrossRefPubMedPubMedCentral
121.
Zurück zum Zitat Sosa CG, Althabe F, Belizan JM, Bergel E (2015) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 3:CD003581 Sosa CG, Althabe F, Belizan JM, Bergel E (2015) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 3:CD003581
122.
Zurück zum Zitat Satterfield N, Newton ER, May LE (2016) Activity in pregnancy for patients with a history of preterm birth. Clin Med Insights Womens Health 9(Suppl 1):17–21PubMedPubMedCentral Satterfield N, Newton ER, May LE (2016) Activity in pregnancy for patients with a history of preterm birth. Clin Med Insights Womens Health 9(Suppl 1):17–21PubMedPubMedCentral
123.
Zurück zum Zitat Saccone G, Berghella V, Venturella R, D’Alessandro P, Arduino B, Raffone A et al (2018) Effects of exercise during pregnancy in women with short cervix: secondary analysis from the Italian pessary trial in singletons. Eur J Obstet Gynecol Reprod Biol 229:132–136CrossRefPubMed Saccone G, Berghella V, Venturella R, D’Alessandro P, Arduino B, Raffone A et al (2018) Effects of exercise during pregnancy in women with short cervix: secondary analysis from the Italian pessary trial in singletons. Eur J Obstet Gynecol Reprod Biol 229:132–136CrossRefPubMed
124.
Zurück zum Zitat Rasanathan K, Bennett S, Atkins V, Beschel R, Carrasquilla G, Charles J et al (2017) Governing multisectoral action for health in low- and middle-income countries. PLoS Med 14(4):e1002285CrossRefPubMedPubMedCentral Rasanathan K, Bennett S, Atkins V, Beschel R, Carrasquilla G, Charles J et al (2017) Governing multisectoral action for health in low- and middle-income countries. PLoS Med 14(4):e1002285CrossRefPubMedPubMedCentral
125.
Zurück zum Zitat Ruckert A, Labonte R (2014) The global financial crisis and health equity: early experiences from Canada. Glob Health 10:2CrossRef Ruckert A, Labonte R (2014) The global financial crisis and health equity: early experiences from Canada. Glob Health 10:2CrossRef
126.
Zurück zum Zitat Manasyan A, Saleem S, Koso-Thomas M, Althabe F, Pasha O, Chomba E et al (2013) Assessment of obstetric and neonatal health services in developing country health facilities. Am J Perinatol 30(9):787–794CrossRefPubMedPubMedCentral Manasyan A, Saleem S, Koso-Thomas M, Althabe F, Pasha O, Chomba E et al (2013) Assessment of obstetric and neonatal health services in developing country health facilities. Am J Perinatol 30(9):787–794CrossRefPubMedPubMedCentral
127.
Zurück zum Zitat Althabe F, Belizan JM, McClure E, Goldenberg RL, Buekens PM (2015) Antenatal corticosteroids for preterm births in resource-limited settings—authors’ reply. Lancet 385(9981):1945CrossRefPubMed Althabe F, Belizan JM, McClure E, Goldenberg RL, Buekens PM (2015) Antenatal corticosteroids for preterm births in resource-limited settings—authors’ reply. Lancet 385(9981):1945CrossRefPubMed
128.
Zurück zum Zitat Berrueta M, Hemingway-Foday J, Thorsten VR, Goldenberg RL, Carlo WA, Garces A et al (2016) Use of antenatal corticosteroids at health facilities and communities in low-and-middle income countries. Reprod Health 13(1):66CrossRefPubMedPubMedCentral Berrueta M, Hemingway-Foday J, Thorsten VR, Goldenberg RL, Carlo WA, Garces A et al (2016) Use of antenatal corticosteroids at health facilities and communities in low-and-middle income countries. Reprod Health 13(1):66CrossRefPubMedPubMedCentral
Metadaten
Titel
Prevention of spontaneous preterm birth
verfasst von
George Daskalakis
Maria Goya
Vasilios Pergialiotis
Luis Cabero
Ioannis Kyvernitakis
Aris Antsaklis
Birgit Arabin
Publikationsdatum
14.02.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-019-05095-y

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