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Erschienen in: Breast Cancer 2/2014

01.03.2014 | Case Report

Primary amelanotic melanoma of the breast: combating a rare cancer

verfasst von: Ahitagni Biswas, Shikha Goyal, Ayushi Jain, Vaishali Suri, Sandeep Mathur, Pramod Kumar Julka, Goura Kishor Rath

Erschienen in: Breast Cancer | Ausgabe 2/2014

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Abstract

Background

Malignant melanoma is the foremost cause of metastasis to the breast from extramammary solid neoplasm. However primary melanoma of the breast is a distinct rarity. Primary melanoma involves the skin and less commonly the glandular parenchyma of the breast.

Method

We herein describe a case of primary amelanotic melanoma of the breast parenchyma in a 32-year-old female managed with a combination of surgery, adjuvant radiotherapy and immunotherapy.

Conclusion

This case report aims to increase awareness of unusual neoplasms of the breast which might require a different surgical and adjuvant therapeutic approach.
Literatur
1.
Zurück zum Zitat Kurul S, Tas F, Buyukbabani N, Mudun A, Baykal C, Camlica H. Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of literature. Jpn J Clin Oncol. 2005;34:202–6. CrossRef Kurul S, Tas F, Buyukbabani N, Mudun A, Baykal C, Camlica H. Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of literature. Jpn J Clin Oncol. 2005;34:202–6. CrossRef
3.
Zurück zum Zitat Roy S, Dhingra K, Mandal S, Khurana N. Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump. Melanoma Res. 2008;18:447–50. PubMedCrossRef Roy S, Dhingra K, Mandal S, Khurana N. Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump. Melanoma Res. 2008;18:447–50. PubMedCrossRef
4.
Zurück zum Zitat Ruffolo EF, Koerner FC, Maluf HM. Metaplastic carcinoma of the breast with melanocytic differentiation. Mod Pathol. 1997;10:592–6. PubMed Ruffolo EF, Koerner FC, Maluf HM. Metaplastic carcinoma of the breast with melanocytic differentiation. Mod Pathol. 1997;10:592–6. PubMed
5.
Zurück zum Zitat Yen H, Florentine B, Kelly LK, Bu X, Crawford J, Martin SE. Fine needle aspiration of a metaplastic breast carcinoma with extensive melanocytic differentiation: a case report. Diagn Cytopathol. 2000;23:46–50. PubMedCrossRef Yen H, Florentine B, Kelly LK, Bu X, Crawford J, Martin SE. Fine needle aspiration of a metaplastic breast carcinoma with extensive melanocytic differentiation: a case report. Diagn Cytopathol. 2000;23:46–50. PubMedCrossRef
6.
Zurück zum Zitat Nobukawa B, Fujii H, Hirai S, Kumasaka T, Shimizu H, Matsumoto T, et al. Breast carcinoma diverging to aberrant melanocytic differentiation: a case report with histopathologic and loss of heterozygosity analyses. Am J Surg Pathol. 1999;23:1280–7. PubMedCrossRef Nobukawa B, Fujii H, Hirai S, Kumasaka T, Shimizu H, Matsumoto T, et al. Breast carcinoma diverging to aberrant melanocytic differentiation: a case report with histopathologic and loss of heterozygosity analyses. Am J Surg Pathol. 1999;23:1280–7. PubMedCrossRef
7.
Zurück zum Zitat Mitchell S, Lachica R, Randall MB, Beech DJ. Paget’s disease of the breast areola mimicking cutaneous melanoma. Breast J. 2006;12:233–6. PubMedCrossRef Mitchell S, Lachica R, Randall MB, Beech DJ. Paget’s disease of the breast areola mimicking cutaneous melanoma. Breast J. 2006;12:233–6. PubMedCrossRef
8.
Zurück zum Zitat Pizzichetta MA, Canzonieri V, Massarut S, Gloghini A, Trevisan G, Veronesi A, et al. Pigmented mammary Paget’s disease mimicking melanoma. Melanoma Res. 2004;14:S13–5. PubMedCrossRef Pizzichetta MA, Canzonieri V, Massarut S, Gloghini A, Trevisan G, Veronesi A, et al. Pigmented mammary Paget’s disease mimicking melanoma. Melanoma Res. 2004;14:S13–5. PubMedCrossRef
9.
Zurück zum Zitat Williams SA, Ehlers RA, Hunt KK, Min Y, Kuerer HM, Singletary SE, et al. Metastases to breast from nonbreast solid neoplasms. Presentation and determinants of survival. Cancer. 2007;110:731–7. PubMedCrossRef Williams SA, Ehlers RA, Hunt KK, Min Y, Kuerer HM, Singletary SE, et al. Metastases to breast from nonbreast solid neoplasms. Presentation and determinants of survival. Cancer. 2007;110:731–7. PubMedCrossRef
10.
Zurück zum Zitat Vaughan A, Dietz JR, Moley JF, De Benedetti MK, Aft RL, Gillanders WE, et al. Metastatic disease to the breast: the Washington University experience. World J Surg Oncol. 2007;5:74. PubMedCentralPubMedCrossRef Vaughan A, Dietz JR, Moley JF, De Benedetti MK, Aft RL, Gillanders WE, et al. Metastatic disease to the breast: the Washington University experience. World J Surg Oncol. 2007;5:74. PubMedCentralPubMedCrossRef
11.
Zurück zum Zitat Ravdel L, Robinson WA, Lewis K, Gonzalez R. Metastatic melanoma in the breast: a report of 27 cases. J Surg Oncol. 2006;94:101–4. PubMedCrossRef Ravdel L, Robinson WA, Lewis K, Gonzalez R. Metastatic melanoma in the breast: a report of 27 cases. J Surg Oncol. 2006;94:101–4. PubMedCrossRef
12.
Zurück zum Zitat Ewing CA, Miller MJ, Chhieng D, Lin O. Nonepithelial malignancies mimicking primary carcinoma of the breast. Diagn Cytopathol. 2004;31:352–7. PubMedCrossRef Ewing CA, Miller MJ, Chhieng D, Lin O. Nonepithelial malignancies mimicking primary carcinoma of the breast. Diagn Cytopathol. 2004;31:352–7. PubMedCrossRef
13.
Zurück zum Zitat Hancock C, Allen BC, Herrera GA. HMB-45 detection in adenocarcinomas. Arch Pathol Lab Med. 1991;115(9):886–90. PubMed Hancock C, Allen BC, Herrera GA. HMB-45 detection in adenocarcinomas. Arch Pathol Lab Med. 1991;115(9):886–90. PubMed
14.
Zurück zum Zitat Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol. 2008;35(5):433–44. PubMedCrossRef Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol. 2008;35(5):433–44. PubMedCrossRef
15.
Zurück zum Zitat Filie AC, Simsir A, Fetsch P, Abati A. Melanoma metastatic to the breast: utility of fine needle aspiration and immunohistochemistry. Acta Cytol. 2002;46:13–8. PubMedCrossRef Filie AC, Simsir A, Fetsch P, Abati A. Melanoma metastatic to the breast: utility of fine needle aspiration and immunohistochemistry. Acta Cytol. 2002;46:13–8. PubMedCrossRef
16.
Zurück zum Zitat Govender D, Sabaratnam RM, Essa AS. Clear cell ‘sugar’ tumor of the breast: another extrapulmonary site and review of the literature. Am J Surg Pathol. 2002;26:670–5. PubMedCrossRef Govender D, Sabaratnam RM, Essa AS. Clear cell ‘sugar’ tumor of the breast: another extrapulmonary site and review of the literature. Am J Surg Pathol. 2002;26:670–5. PubMedCrossRef
17.
Zurück zum Zitat Damiani S, Chiodera P, Guaragni M, Eusebi V. Mammary angiomyolipoma. Virchows Arch. 2002;440:551–2. PubMedCrossRef Damiani S, Chiodera P, Guaragni M, Eusebi V. Mammary angiomyolipoma. Virchows Arch. 2002;440:551–2. PubMedCrossRef
18.
Zurück zum Zitat Thompson JF, McCarthy WH, Bosch CM, O’Brien CJ, Quinn MJ, Paramaesvaran S, et al. Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes. Melanoma Res. 1995;5:255–60. PubMedCrossRef Thompson JF, McCarthy WH, Bosch CM, O’Brien CJ, Quinn MJ, Paramaesvaran S, et al. Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes. Melanoma Res. 1995;5:255–60. PubMedCrossRef
19.
Zurück zum Zitat Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intra-operative lymphatic mapping for early melanoma. Arch Surg. 1992;127:392–9. PubMedCrossRef Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intra-operative lymphatic mapping for early melanoma. Arch Surg. 1992;127:392–9. PubMedCrossRef
20.
Zurück zum Zitat Calabro A, Singletary SE, Balch CM. Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg. 1989;124:1051–5. PubMedCrossRef Calabro A, Singletary SE, Balch CM. Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg. 1989;124:1051–5. PubMedCrossRef
21.
Zurück zum Zitat Lee RJ, Gibbs JF, Proulx GM, Kollmorgen DR, Jia C, Kraybill WG. Nodal basin recurrence following lymph node dissection for melanoma: implications for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2000;46:467–74. PubMedCrossRef Lee RJ, Gibbs JF, Proulx GM, Kollmorgen DR, Jia C, Kraybill WG. Nodal basin recurrence following lymph node dissection for melanoma: implications for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2000;46:467–74. PubMedCrossRef
22.
Zurück zum Zitat Sause WT, Cooper JS, Rush S, Ago CT, Cosmatos D, Couglin CT, et al. Fraction size in external beam radiotherapy in the treatment of melanoma. Int J Radiat Oncol Biol Phys. 1991;20:429–32. PubMedCrossRef Sause WT, Cooper JS, Rush S, Ago CT, Cosmatos D, Couglin CT, et al. Fraction size in external beam radiotherapy in the treatment of melanoma. Int J Radiat Oncol Biol Phys. 1991;20:429–32. PubMedCrossRef
23.
Zurück zum Zitat Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U, Eastern Cooperative Oncology Group. A pooled analysis of Eastern Cooperative Oncology Group and Intergroup trials of adjuvant high dose interferon for melanoma. Clin Cancer Res. 2004;10:1670–7. PubMedCrossRef Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U, Eastern Cooperative Oncology Group. A pooled analysis of Eastern Cooperative Oncology Group and Intergroup trials of adjuvant high dose interferon for melanoma. Clin Cancer Res. 2004;10:1670–7. PubMedCrossRef
Metadaten
Titel
Primary amelanotic melanoma of the breast: combating a rare cancer
verfasst von
Ahitagni Biswas
Shikha Goyal
Ayushi Jain
Vaishali Suri
Sandeep Mathur
Pramod Kumar Julka
Goura Kishor Rath
Publikationsdatum
01.03.2014
Verlag
Springer Japan
Erschienen in
Breast Cancer / Ausgabe 2/2014
Print ISSN: 1340-6868
Elektronische ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-010-0231-8

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