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Erschienen in: Journal of Neuro-Oncology 1/2019

12.12.2018 | Laboratory Investigation

Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival

verfasst von: Quinn T. Ostrom, Haley Gittleman, Carol Kruchko, Jill S. Barnholtz-Sloan

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2019

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Abstract

Background

The Appalachian region is a large geographic and economic area, representing 7.69% of the United States (US). This region is more rural, whiter, older, and has a higher level of poverty as compared to the rest of the US. Limited research has been done on primary brain and other central nervous system tumors (PBT) epidemiology in this region. In this analysis we characterize incidence, mortality, and survival patterns.

Methods

Data from 2006 to 2015 were obtained from the central brain tumor registry of the US (provided by CDC and NCI). Appalachian counties were categorized using the Appalachia Regional Council scheme. Overall and histology-specific age-adjusted incidence and mortality rates per 100,000 population were generated. 1-, 5-, and 10-year relative survival (RS) was estimated using CDC national program of cancer registry data from 2001 to 2014.

Results

Overall PBT incidence within Appalachia was 22.62 per 100,000, which is not significantly different from the non-Appalachian US (22.77/100,000, p = 0.1189). Malignant incidence was 5% higher in Appalachia (7.55/100,000 vs. 7.23/100,000, p < 0.0001), while non-malignant incidence was 3% lower (15.07/100,000 vs. 15.54/100,000, p < 0.0001). 5-year RS for malignant PBT was lower (31.4% vs. 36.0%), and mortality due to malignant PBT was higher in Appalachia (4.86/100,000 vs. 4.34/100,000, p < 0.0001).

Conclusion

Appalachia has increased malignant and decreased non-malignant PBT incidence, and poorer survival outcomes for malignant PBT compared to the non-Appalachian US.
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Metadaten
Titel
Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival
verfasst von
Quinn T. Ostrom
Haley Gittleman
Carol Kruchko
Jill S. Barnholtz-Sloan
Publikationsdatum
12.12.2018
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 1/2019
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-018-03073-z

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