Skip to main content
Erschienen in: Head and Neck Pathology 4/2018

13.03.2018 | Original Paper

Primary Leiomyosarcoma of the Buccal Mucosa: Report of a Case and Review of the Literature

verfasst von: Eugene M. Ko, Jonathan B. McHugh

Erschienen in: Head and Neck Pathology | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

This clinicopathologic study of primary oral leiomyosarcoma of the buccal mucosa involves a literature review of 15 cases with the addition of our report of a case. The demographic details, tumor size, treatment and outcome are documented for all the cases. In addition, this review examines the histologic features of leiomyosarcoma while noting that differentiation from other spindle cell tumors can be challenging, underscoring the necessity of an immunohistochemical work up for an accurate diagnosis. The unpredictability of the clinical behavior of these aggressive tumors requires, at the very least, wide local surgical excision and prolonged follow up.
Literatur
1.
Zurück zum Zitat Solar AA, Jordan RC. Soft tissue tumors and common metastases of the oral cavity. Periodontol 2000. 2011;57(1):177–97.CrossRef Solar AA, Jordan RC. Soft tissue tumors and common metastases of the oral cavity. Periodontol 2000. 2011;57(1):177–97.CrossRef
2.
Zurück zum Zitat Schutz A, Smeets R, Driemel O, Hakim SG, Kosmehl H, Hanken H, Kolk A. Primary and secondary leiomyosarcoma of the oral and perioral region–clinicopathological and immunohistochemical analysis of a rare entity with a review of the literature. J Oral Maxillofac Surg. 2013;71(6):1132–42.CrossRef Schutz A, Smeets R, Driemel O, Hakim SG, Kosmehl H, Hanken H, Kolk A. Primary and secondary leiomyosarcoma of the oral and perioral region–clinicopathological and immunohistochemical analysis of a rare entity with a review of the literature. J Oral Maxillofac Surg. 2013;71(6):1132–42.CrossRef
3.
Zurück zum Zitat Schenberg ME, Slootweg PJ, Koole R. Leiomyosarcomas of the oral cavity. Report of four cases and review of the literature. J Cranio-Maxillofac Surg. 1993;21(8):342–7.CrossRef Schenberg ME, Slootweg PJ, Koole R. Leiomyosarcomas of the oral cavity. Report of four cases and review of the literature. J Cranio-Maxillofac Surg. 1993;21(8):342–7.CrossRef
4.
Zurück zum Zitat Yan B, Li Y, Pan J, Xia H, Li LJ. Primary oral leiomyosarcoma: a retrospective clinical analysis of 20 cases. Oral Dis. 2010;16(2):198–203.CrossRef Yan B, Li Y, Pan J, Xia H, Li LJ. Primary oral leiomyosarcoma: a retrospective clinical analysis of 20 cases. Oral Dis. 2010;16(2):198–203.CrossRef
5.
Zurück zum Zitat Lo Muzio L, Favia G, Mignogna MD, Piattelli A, Maiorano E. Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature. Oral Oncol. 2000;36(6):519–24.CrossRef Lo Muzio L, Favia G, Mignogna MD, Piattelli A, Maiorano E. Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature. Oral Oncol. 2000;36(6):519–24.CrossRef
6.
Zurück zum Zitat Dry J, Fletcher M. Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours. Histopathology 2000;36(3):210–20.CrossRef Dry J, Fletcher M. Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours. Histopathology 2000;36(3):210–20.CrossRef
7.
Zurück zum Zitat Eppsteiner RW, DeYoung BR, Milhem MM, Pagedar NA. Leiomyosarcoma of the head and neck: a population-based analysis. Arch Otolaryngol Head Neck Surg. 2011;137(9):921–4.CrossRef Eppsteiner RW, DeYoung BR, Milhem MM, Pagedar NA. Leiomyosarcoma of the head and neck: a population-based analysis. Arch Otolaryngol Head Neck Surg. 2011;137(9):921–4.CrossRef
8.
Zurück zum Zitat Izumi K, Maeda T, Cheng J, Saku T. Primary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80(3):310–9.CrossRef Izumi K, Maeda T, Cheng J, Saku T. Primary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80(3):310–9.CrossRef
9.
Zurück zum Zitat Vilos GA, Rapidis AD, Lagogiannis GD, Apostolidis C. Leiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 cases. J Oral Maxillofac Surg. 2005;63(10):1461–77.CrossRef Vilos GA, Rapidis AD, Lagogiannis GD, Apostolidis C. Leiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 cases. J Oral Maxillofac Surg. 2005;63(10):1461–77.CrossRef
10.
Zurück zum Zitat De Bree R, Van Der Waal I, De Bree E, René Leemans C. Management of adult soft tissue sarcomas of the head and neck. Oral Oncol. 2010;46(11):786–90.CrossRef De Bree R, Van Der Waal I, De Bree E, René Leemans C. Management of adult soft tissue sarcomas of the head and neck. Oral Oncol. 2010;46(11):786–90.CrossRef
12.
Zurück zum Zitat Ahn JH, Mirza T, Ameerally P. Leiomyosarcoma of the tongue with multiple metastases: a case report and review of literature. J Oral Maxillofac Surg. 2012;70(7):1745–50.CrossRef Ahn JH, Mirza T, Ameerally P. Leiomyosarcoma of the tongue with multiple metastases: a case report and review of literature. J Oral Maxillofac Surg. 2012;70(7):1745–50.CrossRef
13.
Zurück zum Zitat Nikitakis NG, Lopes MA, Bailey JS, Blanchaert RH Jr, Ord RA, Sauk JJ. Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers. Oral Oncol. 2002;38(2):201–8.CrossRef Nikitakis NG, Lopes MA, Bailey JS, Blanchaert RH Jr, Ord RA, Sauk JJ. Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers. Oral Oncol. 2002;38(2):201–8.CrossRef
14.
Zurück zum Zitat Montgomery E, Goldblum JR, Fisher C. Leiomyosarcoma of the head and neck: a clinicopathological study. Histopathology 2002;40(6):518–25.CrossRef Montgomery E, Goldblum JR, Fisher C. Leiomyosarcoma of the head and neck: a clinicopathological study. Histopathology 2002;40(6):518–25.CrossRef
15.
Zurück zum Zitat Fernandez-Flores A. Epstein-Barr virus in cutaneous pathology. Am J Dermatopathol. 2013;35(8):763–86.CrossRef Fernandez-Flores A. Epstein-Barr virus in cutaneous pathology. Am J Dermatopathol. 2013;35(8):763–86.CrossRef
16.
Zurück zum Zitat Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D. Chromothripsis from DNA damage in micronuclei. Nature 2015;522(7555):179–84.CrossRef Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D. Chromothripsis from DNA damage in micronuclei. Nature 2015;522(7555):179–84.CrossRef
17.
Zurück zum Zitat Chudasama P, Mughal SS, Sanders MA, Hubschmann D, Chung I, Deeg KI, Wong SH, Rabe S, Hlevnjak M, Zapatka M, et al. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun. 2018;9(1):144.CrossRef Chudasama P, Mughal SS, Sanders MA, Hubschmann D, Chung I, Deeg KI, Wong SH, Rabe S, Hlevnjak M, Zapatka M, et al. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun. 2018;9(1):144.CrossRef
18.
Zurück zum Zitat Chang AE, Chai X, Pollack SM, Loggers E, Rodler E, Dillon J, Parvathaneni U, Moe KS, Futran N, Jones RL. Analysis of clinical prognostic factors for adult patients with head and neck sarcomas. Otolaryngol Head Neck Surg. 2014;151(6):976–83.CrossRef Chang AE, Chai X, Pollack SM, Loggers E, Rodler E, Dillon J, Parvathaneni U, Moe KS, Futran N, Jones RL. Analysis of clinical prognostic factors for adult patients with head and neck sarcomas. Otolaryngol Head Neck Surg. 2014;151(6):976–83.CrossRef
19.
Zurück zum Zitat Krishnan V, Miyaji CM, Mainous EG. Leiomyosarcoma of the mandible: a case report. J Oral Maxillofac Surg. 1991;49(6):652–5.CrossRef Krishnan V, Miyaji CM, Mainous EG. Leiomyosarcoma of the mandible: a case report. J Oral Maxillofac Surg. 1991;49(6):652–5.CrossRef
20.
Zurück zum Zitat Robinson EC, Whyte AM. Leiomyosarcoma of the cheek: a case report. Br J Oral Surg. 1978;16(2):100–4.CrossRef Robinson EC, Whyte AM. Leiomyosarcoma of the cheek: a case report. Br J Oral Surg. 1978;16(2):100–4.CrossRef
21.
Zurück zum Zitat Mesquita RA, Migliari DA, de Sousa SO, Alves MR. Leiomyosarcoma of the buccal mucosa: a case report. J Oral Maxillofac Surg. 1998;56(4):504–7.CrossRef Mesquita RA, Migliari DA, de Sousa SO, Alves MR. Leiomyosarcoma of the buccal mucosa: a case report. J Oral Maxillofac Surg. 1998;56(4):504–7.CrossRef
22.
Zurück zum Zitat Yadav R, Bharathan S. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings. J Oral Sci. 2008;50(2):215–8.CrossRef Yadav R, Bharathan S. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings. J Oral Sci. 2008;50(2):215–8.CrossRef
23.
Zurück zum Zitat Ethunandan M, Stokes C, Higgins B, Spedding A, Way C, Brennan P. Primary oral leiomyosarcoma: a clinico-pathologic study and analysis of prognostic factors. Int J Oral Maxillofac Surg. 2007;36(5):409–16.CrossRef Ethunandan M, Stokes C, Higgins B, Spedding A, Way C, Brennan P. Primary oral leiomyosarcoma: a clinico-pathologic study and analysis of prognostic factors. Int J Oral Maxillofac Surg. 2007;36(5):409–16.CrossRef
24.
Zurück zum Zitat Nagpal DKJ, Prabhu PR, Shah A, Palaskar S. Leimyosarcoma of the buccal mucosa and review of literature. J Oral Maxillofac Pathol. 2013;17(1):149.CrossRef Nagpal DKJ, Prabhu PR, Shah A, Palaskar S. Leimyosarcoma of the buccal mucosa and review of literature. J Oral Maxillofac Pathol. 2013;17(1):149.CrossRef
25.
Zurück zum Zitat Suarez-Alen F, Otero-Rey E, Penamaria-Mallon M, Garcia-Garcia A, Blanco-Carrion A. Oral leiomyosarcoma: the importance of early diagnosis. Gerodontology 2015;32(4):314–7.CrossRef Suarez-Alen F, Otero-Rey E, Penamaria-Mallon M, Garcia-Garcia A, Blanco-Carrion A. Oral leiomyosarcoma: the importance of early diagnosis. Gerodontology 2015;32(4):314–7.CrossRef
Metadaten
Titel
Primary Leiomyosarcoma of the Buccal Mucosa: Report of a Case and Review of the Literature
verfasst von
Eugene M. Ko
Jonathan B. McHugh
Publikationsdatum
13.03.2018
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 4/2018
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-018-0907-5

Weitere Artikel der Ausgabe 4/2018

Head and Neck Pathology 4/2018 Zur Ausgabe

Neu im Fachgebiet Pathologie