The online version of this article (doi:10.1186/1477-7819-10-151) contains supplementary material, which is available to authorized users.
An erratum to this article is available at http://dx.doi.org/10.1186/1477-7819-10-217.
The authors declare that they have no competing interests.
MB drafted the manuscript. All authors read and approved the final manuscript. All authors read and approved the final manuscript.
Primary breast lymphoma is an uncommon disease with poor clinical outcome. Breast lymphomas present less than 0.5% of malignant breast neoplasms and 2.2% of extranodal lymphomas. This study investigated the clinicopathological features and optimal treatment of PBL.
Clinical records of seven Moroccan PBL patients, treated at the National Institute of Oncology, Rabat, Morocco, from 2002 to 2010, were reviewed. Six of the patients were women and one a man, with ages ranging from 32 to 76. Five patients had stage IE and two stage IIE. All of the patients were classified with DLBCL. Of seven patients, one received a mastectomy and three excision of the breast lesion. Axillary dissection was performed in three patients. Two patients received chemotherapy followed by radiotherapy, while four received chemotherapy alone. Complete remission (CR) following primary treatment for all patients with PBL except in two cases was obtained. In one patient, recurrence occurred.
There is no consensus on the question of how to best treat PBL: Mastectomy offers no benefit in the treatment of PBL. The combined therapy approach, with chemotherapy and radiotherapy, is the most successful treatment. PBL is poorly represented in rituximab-containing trials in DLBCL patients; there is not much experience with this agent in breast DLBCL. Because of the high incidence of central nervous system (CNS) involvement in PBL patients, many authors strongly believe that patients with aggressive forms of PBL should receive CNS infiltration prophylaxis.
Jinming X, Qi Z, Xiaoming Z, Jianming T: Primary non-Hodgkin’s lymphoma of the breast: mammography, ultrasound, MRI and pathologic findings. Futur Oncol. 2012, 8 (1): 105-109. 10.2217/fon.11.132. CrossRef
Tavassoli FA, Devilee P: WHO classification of tumours: pathology and genetics of tumours of the breast and female genital organs. 2003, IARC Press, Lyon
Carbone PP, Kaplan HS, Mushoff K, Smithers DW, Tubiana M: Report of the committee on Hodgkin’s disease classification. Cancer Res. 1971, 31: 1860-1861. PubMed
Nicola A, Alessandro S, Roberto C, Giovanni B, Stefano T: Primary breast lymphomas: a multicentric experience. World J Surg Oncol. 2010, 8: 53-10.1186/1477-7819-8-53. CrossRef
Sandeep Kumar A, Nalini G, Radhika S, Ashim D: Non-Hodgkin’s lymphoma presenting as breast masses: a series of 10 cases diagnosed on FNAC. Diagn Cytopathol. 2011, 10.1002/dc.21763
Popović L, Jovanović D, Matovina-Brko G, Petrović D, Nikin Z: Primary diffuse large B-cell lymphoma of the breast. Arch Oncol. 2007, 17 (3–4): 80-82.
Yetim I, Durgun Yetim T, Orhan VÖ, Güvenç D, Nazan S: Bilateral primary breast lymphoma: a rare case. J Breast Health. 2011, 7 (3): 185-187.
Lbrahim MH-, Singletary S: Ann. Surgical management of primary lymphoma of the breast. Ann Surg. 1991, 214 (6): 725-
Fu K, Perry KD, Smith LM: Effect of addition of rituximab to CHOP on survival of patients in both the GCB and non-GCB subgroups of diffuse large B-cell lymphoma. ASCO Annual Meeting Proceedings Part I. J Clin Oncol. 2007, 25 (18 Suppl): Abstr 8040-
Lenz G, Wright G, Sandeep D: Gene expression signatures predict overall survival in diffuse large B-cell lymphoma treated with rituximab and CHOP-like chemotherapy. Blood. 2007, 110: 209a-Abstr 348.
Jeanneret-Sozzi W, Taghian A, Epelbaum R: Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre Rare Cancer Network study. BMC Canc. 2008, 8: 86-10.1186/1471-2407-8-86. CrossRef
- Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review
El Harroudi Tijani
- BioMed Central
Neu im Fachgebiet Chirurgie
Mail Icon II