nach oben

Erschienen in:

01.03.2012 | Gynecologic Oncology

Primary metastasized extraskeletal Ewing sarcoma of the vulva: report of a case and review of the literature

verfasst von: Katharina Kelling, Frank Noack, Christopher Altgassen, Peter Kujath, Michael K. Bohlmann, Friederike Hoellen

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Ewing’s sarcoma (ES) and primitive neuroectodermal tumor (PNET) are closely related malignant neoplasms, usually affecting the skeletal system. Extraosseous ES/PNETs are uncommon, with occasional reports of tumors affecting the genitourinary tract. Only few cases of primary vulvar Ewing’s sarcoma/PNET have previously been reported.

Methods

We present a patient with primary vulvar Ewing's sarcoma with pulmonary metastasis who presented at the Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck.

Results

The present report is the third case of a primary vulvar Ewing's sarcoma and the first constellation with pulmonary metastasis at diagnosis in the current literature. We present the diagnostic and therapeutic management including surgery, chemotherapy and radiation.

Conclusion

The treatment of the Ewing’s sarcomas and PNETs requires a multidisciplinary systemic approach. Despite its rarity, the differential diagnosis of vulvar sarcoma must be considered in young women.

Al-Tamimi H, Al-Hadi AA, Al-Khater AH, Al-Bozom I, Al-Sayed N (2009) Extraskeletal neuroectodermal tumour of the vagina: a single case report and review. Arch Gynecol Obstet 280(3):465–468PubMedCrossRef

Carvajal R, Meyers P (2005) Ewing’s sarcoma and primitive neuroectodermal family of tumors. Hematol Oncol Clin North Am 19(3):501–525

Dehner LP (1993) Primitive neuroectodermal tumor and Ewing’s sarcoma. Am J Surg Pathol 17(1):1–13PubMedCrossRef

Farley J, O’Boyle JD, Heaton J, Remmenga S (2000) Extraosseous Ewing sarcoma of the vagina. Obstet Gynecol 96(5 Pt 2):832–834PubMedCrossRef

Fong YE, Lopez-Terrada D, Zhai QJ (2008) Primary Ewing sarcoma/peripheral primitive neuroectodermal tumor of the vulva. Hum Pathol 39(10):1535–1539PubMedCrossRef

Gaona-Luviano P, Unda-Franco E, Gonzalez-Jara L, Romero P, Medina-Franco H (2003) Primitive neuroectodermal tumor of the vagina. Gynecol Oncol 91(2):456–458PubMedCrossRef

Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore S, Rausen AR, Vietti TJ, Miser JS (2003) Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 348(8):694–701PubMedCrossRef

Habib K, Finet JF, Plantier F, Spatz A, Sfoggia D, Fitoussi F (1992) Rare lesion of the vulva. Arch Anat Cytol Pathol 40(2–3):158–159PubMed

Horowitz MC, Delaney TF, Malawar MM, Tsokos MG (1993) Ewing’s sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors. Principles and practice of pediatric oncology. Lippincott, Philadelphia

10.

Khoury JD (2005) Ewing sarcoma family of tumors. Adv Anat Pathol 12(4):212–220PubMedCrossRef

11.

Lazure T, Alsamad IA, Meuric S, Orbach D, Fabre M (2001) Primary uterine and vulvar Ewing’s sarcoma/peripheral neuroectodermal tumors in children: two unusual locations. Ann Pathol 21(3):263–266PubMed

12.

Liao X, Xin X, Lu X (2004) Primary Ewing’s sarcoma-primitive neuroectodermal tumor of the vagina. Gynecol Oncol 92(2):684–688PubMedCrossRef

13.

McCluggage WG, Sumathi VP, Nucci MR, Hirsch M, Dal Cin P, Wells M, Flanagan AM, Fisher C (2007) Ewing family of tumours involving the vulva and vagina: report of a series of four cases. J Clin Pathol 60(6):674–680PubMedCrossRef

14.

Meis-Kindblom JM, Stenman G, Kindblom LG (1996) Differential diagnosis of small round cell tumors. Semin Diagn Pathol 13(3):213–241PubMed

15.

Moodley M, Jordaan A (2005) Ewing’s sarcoma of the vulva—a case report. Int J Gynecol Cancer 15(6):1177–1178PubMedCrossRef

16.

Nirenberg A, Ostor AG, Slavin J, Riley CB, Rome RM (1995) Primary vulvar sarcomas. Int J Gynecol Pathol 14(1):55–62PubMedCrossRef

17.

Paredes E, Duarte A, Couceiro A, Fernandes D, Alves A, Bastos S (1995) A peripheral neuroectodermal tumor of the vulva. Acta Med Port 8(3):161–163PubMed

18.

Rud NP, Reiman HM, Pritchard DJ, Frassica FJ, Smithson WA (1989) Extraosseous Ewing’s sarcoma. A study of 42 cases. Cancer 64(7):1548–1553PubMedCrossRef

19.

Scherr GR, d’Ablaing G 3rd, Ouzounian JG (1994) Peripheral primitive neuroectodermal tumor of the vulva. Gynecol Oncol 54(2):254–258PubMedCrossRef

20.

Soulard R, Claude V, Camparo P, Dufau JP, Saint-Blancard P, Gros P (2005) Primitive neuroectodermal tumor of the stomach. Arch Pathol Lab Med 129(1):107–110PubMed

21.

Strauss SJ, McTiernan A, Driver D, Hall-Craggs M, Sandison A, Cassoni AM, Kilby A, Michelagnoli M, Pringle J, Cobb J, Briggs T, Cannon S, Witt J, Whelan JS (2003) Single center experience of a new intensive induction therapy for Ewing’s family of tumors: feasibility, toxicity, and stem cell mobilization properties. J Clin Oncol 21(15):2974–2981PubMedCrossRef

22.

Takeshima N, Tabata T, Nishida H, Furuta N, Tsuzuku M, Hirai Y, Hasumi K (2001) Peripheral primitive neuroectodermal tumor of the vulva: report of a case with imprint cytology. Acta Cytol 45(6):1049–1052PubMedCrossRef

23.

Vang R, Taubenberger JK, Mannion CM, Bijwaard K, Malpica A, Ordonez NG, Tavassoli FA, Silver SA (2000) Primary vulvar and vaginal extraosseous Ewing’s sarcoma/peripheral neuroectodermal tumor: diagnostic confirmation with CD99 immunostaining and reverse transcriptase-polymerase chain reaction. Int J Gynecol Pathol 19(2):103–109PubMedCrossRef

24.

Cetiner H, Kir G, Gelmann EP, Ozdemirli M (2009) Primary vulvar Ewing sarcoma/primitive neuroectodermal tumor: a report of 2 cases and review of the literature. Int J Gynecol Cancer 19(6):1131–1136PubMedCrossRef

25.

Dadhwal V, Bahadur A, Gupta R, Bansal S, Mittal S (2010) Peripheral neuroectodermal tumor of the vulva: a case report. J Low Genit Tract Dis 14(1):59–62PubMedCrossRef

26.

Halil S, Kucuk M, Arvas M, Aydin O, Calay ZZ (2011) Peripheral primitive neuroectodermal tumor (PNET) of the vulva: a case report. Eur J Gynaecol Oncol 32(1):117–118PubMed

Titel: Primary metastasized extraskeletal Ewing sarcoma of the vulva: report of a case and review of the literature
verfasst von: Katharina Kelling
Frank Noack
Christopher Altgassen
Peter Kujath
Michael K. Bohlmann
Friederike Hoellen
Publikationsdatum: 01.03.2012
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2011-x

Neu im Fachgebiet Gynäkologie und Geburtshilfe

22.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Primary metastasized extraskeletal Ewing sarcoma of the vulva: report of a case and review of the literature

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Update Gynäkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2012

Association of kisspeptin-10 levels with abortus imminens: a preliminary study

Role of serum interleukin-6 in comparing surgical stress after laparoscopic-assisted vaginal hysterectomy and non-descent vaginal hysterectomy for large uteri

Reduction of postoperative adhesions by trimetazidine: an experimental study in a rat model

Takayasu arteritis in pregnancy: an analysis from eastern India

Anal incontinence and quality of life following obstetric anal sphincter injury

Diagnosis and therapy of polycystic ovarian syndrome: results of a survey among German gynecologists with a review on literature

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Update Gynäkologie