nach oben

Nuclear Medicine and Molecular Imaging

Erschienen in:

09.03.2017 | Case Report

Primary Renal Leiomyosarcoma Presenting with Subcutaneous and Osseous Metastases: Staging and Follow-Up with 18F-FDG PET/CT

verfasst von: William Makis, Fadi Brimo, Stephan Probst

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

A 60 year old woman who presented with multiple small subcutaneous nodules in the upper back and arms, was referred for an [18F] fluoro-2-deoxy-D-glucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) after histological evaluation revealed metastatic leiomyosarcoma of unknown origin. The PET/CT showed multiple ¹⁸F-FDG-avid subcutaneous nodules, bone lesions, as well as a large left renal mass, which was biopsied to confirm a primary renal leiomyosarcoma arising from the renal parenchyma. A post therapy PET/CT showed overall progression of disease. The use of ¹⁸F-FDG PET/CT in the staging and evaluation of response to therapy of a renal leiomyosarcoma has not been previously described in the literature.

Miller JS, Zhou M, Brimo F, Guo CC, Epstein JI. Primary leiomyosarcoma of the kidney: a clinicopathologic study of 27 cases. Am J Surg Pathol. 2010;34:238–42.CrossRefPubMed

Moazzam M, Ather MH, Hussainy AS. Leiomyosarcoma presenting as a spontaneously ruptured renal tumor—case report. BMC Urol. 2002;2:13.CrossRefPubMedPubMedCentral

Martinez-Cornelio A, Ramos-Salgado F, Hernandez-Ramirez D, Garcia-Alvarez G, Alvarado-Cabrero I, Hernandez-Toriz N. Leiomyosarcoma of the kidney: case report. Cir Cir. 2011;79:282–5.

Valery JR, Tan W, Cortese C. Renal leiomyosarcoma: a diagnostic challenge. Case Rep Oncol Med. 2013;459282.

Choudhury M, Singh SK, Pujani M, Pathania OP. A case of leiomyosarcoma of kidney clinically and radiologically misdiagnosed as renal cell carcinoma. Indian J Cancer. 2009;46:241–3.CrossRefPubMed

Bhat GS, Nelivigi GG, Shivalingaiah M, Ratkal CS. Primary renal leiomyosarcoma: case report and literature review. Afr J Urol. 2011;17:15–17.

Ioannidis J, Lau J. 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma: a meta-analysis. J Nucl Med. 2003;44:717–24.PubMed

Feldman F, van Heertum R, Manos C. 18FDG PET scanning of benign and malignant musculoskeletal lesions. Skelet Radiol. 2003;32:201–8.CrossRef

Rivera L, Gandikota N, Love C, Yang J, Libes R, Rosen G, et al. Role of F-18-FDG PET/CT in follow-up of patients with treated leiomyosarcoma. J Nucl Med. 2010;51 Suppl 2:513.

10.

Punt S, Eary JF, O’Sullivan J, Conrad EU. Fluorodeoxyglucose positron emission tomography in leiomyosarcoma: imaging characteristics. Nucl Med Commun. 2009;30:546–9.CrossRefPubMedPubMedCentral

11.

Charest M, Hickeson M, Lisbona R, Novales-Diaz JA, Derbekyan V, Turcotte RE. FDG PET/CT imaging in primary osseous and soft tissue sarcomas: a retrospective review of 212 cases. Eur J Nucl Med Mol Imaging. 2009;36:1944–51.CrossRefPubMed

12.

Vogelzang NJ, Fremgen AM, Guinan PD, Chmiel JS, Sylvester JL, Sener SF. Primary renal sarcoma in adults: a natural history and management study by the American Cancer Society, Illinois division. Cancer. 1993;71:804–10.CrossRefPubMed

13.

Davis R, Vaccaro JA, Hodges GF, Belville WD, Kiesling Jr V. Renal leiomyosarcoma: plea for aggressive therapy. Urology. 1992;40:168–71.CrossRefPubMed

14.

Sharma D, Pradhan S, Aryya NC, Shukla VK. Leiomyosarcoma of kidney—a case report with long term result after radiotherapy and chemotherapy. Int Urol Nephrol. 2007;39:397–400.CrossRefPubMed

Titel: Primary Renal Leiomyosarcoma Presenting with Subcutaneous and Osseous Metastases: Staging and Follow-Up with 18F-FDG PET/CT
verfasst von: William Makis
Fadi Brimo
Stephan Probst
Publikationsdatum: 09.03.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Nuclear Medicine and Molecular Imaging / Ausgabe 1/2018
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-016-0467-0

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2018

Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies

Multiple Regression Analysis of Predictors of Bone Scintigraphy Positivity in Patients with Head and Neck Cancers

Erratum to: Dual Pathologies of Parathyroid Adenoma and Papillary Thyroid Cancer on Fluorocholine and Fluorodeoxyglucose PET/CT

Prognostic Value of Pre- and Post-Treatment FDG PET/CT Parameters in Small Cell Lung Cancer Patients

PERCIST in Perspective

Evaluation of 18F-FDG PET/CT Parameters for Detection of Lymph Node Metastasis in Cutaneous Melanoma