The online version of this article (doi:10.1186/1477-7819-10-32) contains supplementary material, which is available to authorized users.
Dansong Wang, Yefei Rong contributed equally to this work.
The authors declare that they have no competing interests.
DSW, YFR and DYJ: Operating team and drafted the manuscript; WCW: operating team, post-surgery care. All authors read and approve the final manuscript.
Primary small cell carcinoma of the pancreas (SCCP) is a rare malignancy with an extremely poor prognosis which accounts for 1 to 1.4 percent of all pancreatic malignancies.
We present the case of a 62-year-old man with a half-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreatic tail. A Chest X-ray showed no evidence of primary lung tumor. The diagnosis of a SCCP was confirmed by post-surgery pathology and immunohistology. In our review of the published reports of SCCP, we only found a few cases reported in the literatures. The diagnosis of SCCP needs the post-surgery pathology and immunohistology and the prognosis of SCCP is extremely poor. There was a significant increase in median survival, from 1 to 6 months, in treated patients compared to patients treated only by symptomatic management. Chemotherapy was the most common treatment and the combination of cisplatin/etoposide was most frequently prescribed.
The accurate diagnosis of (SCCP) is necessary for determining prognosis and deciding appropriate therapy.
Percy C, Sabin L: Survelliance, epidemiology and end-results lung cancer data applied to the World Health Organization classification of lung tumors. J Natl Cancer Inst. 1983, 70: 663-666. PubMed
Ichikawa T, Federle MP, Ohba S, Ohtomo K, Sugiyama A, Fujimoto H, Haradome H, Araki T: Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients. Abdom Imaging. 2000, 25 (4): 409-419. 10.1007/s002610000058. CrossRefPubMed
Johnson DH, Marangos PJ, Forbes JT, Hainsworth JD, Van Welch R, Hande KR, Greco FA: Potential utility of serum neuron-specific enolase levels in small cell carcinoma of the lung. Cancer Res. 1984, 44: 5409-5414. PubMed
O'Connor TP, Wade TP, Sunwoo YC, Reimers HJ, Palmer DC, Silverberg AB, Johnson FE: Small cell undifferentiated carcinoma of the pancreas: report of a patient with tumor marker studies. Cancer. 1992, 70 (6): 1514-1519. 10.1002/1097-0142(19920915)70:6<1514::AID-CNCR2820700612>3.0.CO;2-C. CrossRefPubMed
Shibayama T, Ueoka H, Nishii K, Kiura K, Tabata M, Miyatake K, Kitajima T, Harada M: Complementary roles of pro-gastrin-releasing peptide (Pro-GRP) and neuron-specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC). Lung Cancer. 2011, 32 (1): 61-69. CrossRef
Suzuki H, Takayanagi S, Otake T, Ishibashi R, Osawa S, Shirai T, Takashima M, Hanai H, Kaneko E: Primary small cell carcinoma of the esophagus with achalasia in a patient in whom pro-gastrin-releasing peptide and neuron-specific enolase levels reflected the clinical course during chemotherapy. J Gastroenterol. 1999, 34 (3): 378-382. 10.1007/s005350050278. CrossRefPubMed
Vos Bertrand, Awada Ahmad, Hendlisz Alain: Primary small-cell carcinoma of the pancreas: An extensive review of the literature with emphasis on therapy and prognosis. Cancer Therapy. 2008, 6: 857-864.
Yachida S, Zhong Y, Patrascu R, Davis MB, Morsberger LA, Griffin CA, Hruban RH, Laheru D, Iacobuzio-Donahue CA: Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas. Pancreas. 2011, 40 (6): 905-910. 10.1097/MPA.0b013e3182207a58. PubMedCentralCrossRefPubMed
- Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures
- BioMed Central
Neu im Fachgebiet Chirurgie
Mail Icon II