B-cell lymphoma is the third most common tumor of the colon (following adenocarcinoma and carcinoid) but still comprises only 0.5% of all colonic tumors [
10]. Despite its rarity, it should be noted that its frequency seems to be rising, especially in North America [
11]. It is thought that primary NHL of the colon arises from mucosa-associated lymphatic tissue of the colon [
5]. The subtype diffuse large B-cell lymphoma is the most common subtype, and the most common colonic site for this tumor is the cecum [
5]. This is presumably due to the excess of lymphatic tissue in this region. The cecum is then followed by the right colon and the sigmoid colon. Symptoms described in the literature are varied and include abdominal pain, weight loss, hematochezia, abdominal mass, intussusception, intestinal obstruction, and even perforation and peritonitis [
1,
3,
5,
10], and it is estimated that 20% of patients require emergent surgery [
11]. This disease usually affects older people (the median age is older than 55 years) and mostly men [
12]. Risk factors for colonic NHL are autoimmune diseases such as inflammatory bowel disease, celiac disease, and human immunodeficiency virus carrier status [
13]. The treatment of colonic lymphoma includes a combination of surgery and chemotherapy [
14] and depends on the staging of the disease. The lower stages of disease are treated with surgery and complemented by adjuvant polychemotherapy, whereas the more advanced stages are treated with multidrug chemotherapy (mostly CHOP [cyclophosphamide, doxorubicin, vincristine, prednisone]), or other combinations of chemotherapy and rituximab (R-CHOP [cyclophosphamide, doxorubicin, vincristine, prednisone, rituximab]) [
10,
11,
15]. A recent review of the literature [
10] that covered 20 publications regarding colonic lymphoma included only 2 cases of small cell lymphoma.