nach oben

European Journal of Pediatrics

Erschienen in:

19.12.2016 | Original Article

(Pro)renin and (pro)renin receptor expression during kidney development in neonates

verfasst von: Tomomasa Terada, Maki Urushihara, Takahiko Saijo, Ryuji Nakagawa, Shoji Kagami

Erschienen in: European Journal of Pediatrics | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates were stronger than those in minor glomerular abnormalities.

Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans.

What is Known:

• Renal renin-angiotensin system (RAS) has several pathophysiologic functions not only in blood pressure regulation but also in pediatric renal disease.

• Renal RAS activation plays a key role of renal development during gestation.

What is New :

• Plasma (pro)renin and soluble (pro)renin receptor (s(P)RR) levels in cord blood were significantly higher in preterm neonates than in full-term neonates.

• Immunohistochemical analysis of kidney tissue indicated that renal expression levels of (P)RR in neonates were stronger than in minor glomerular abnormalities.

Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S, Hopkins N (2004) Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A 101:12792–12797CrossRefPubMedPubMedCentral

el-Dahr SS, Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL (1990) In situ localization of renin and its mRNA in neonatal ureteral obstruction. Am J Phys 258:F854–F862

Gomez RA, Robillard JE (1984) Developmental aspects of the renal responses to hemorrhage during converting-enzyme inhibition in fetal lambs. Circ Res 54:301–312CrossRefPubMed

Gonzalez AA, Lara LS, Luffman C, Seth DM, Prieto MC (2011) Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats. Hypertension 57:859–864CrossRefPubMedPubMedCentral

Gubler MC, Antignac C (2010) Renin-angiotensin system in kidney development: renal tubular dysgenesis. Kidney Int 77:400–406CrossRefPubMed

Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y (2011) Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study. Hypertens Res 34:530–535CrossRefPubMed

Ichihara A, Kinouchi K (2011) Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase. J Renin-Angiotensin-Aldosterone Syst 12:638–640CrossRefPubMed

Kinouchi K, Ichihara A, Sano M, Sun-Wada GH, Wada Y, Kurauchi-Mito A, Bokuda K, Narita T, Oshima Y, Sakoda M, Tamai Y, Sato H, Fukuda K, Itoh H (2010) The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res 107:30–34CrossRefPubMed

Madsen K, Tinning AR, Marcussen N, Jensen BL (2013) Postnatal development of the renal medulla; role of the renin-angiotensin system. Acta Physiol 208:41–49CrossRef

10.

Mahieu-Caputo D, Dommergues M, Delezoide AL, Lacoste M, Cai Y, Narcy F, Jolly D, Gonzales M, Dumez Y, Gubler MC (2000) Twin-to-twin transfusion syndrome. Role of the fetal renin-angiotensin system. Am J Pathol 156:629–636CrossRefPubMedPubMedCentral

11.

Martinovic J, Benachi A, Laurent N, Daikha-Dahmane F, Gubler MC (2001) Fetal toxic effects and angiotensin-II-receptor antagonists. Lancet 358:241–242CrossRefPubMed

12.

Maruyama N, Segawa T, Kinoshita N, Ichihara A (2013) Novel sandwich ELISA for detecting the human soluble (pro)renin receptor. Front Biosci (Elite Ed) 5:583–590CrossRef

13.

Mounier F, Hinglais N, Sich M, Gros F, Lacoste M, Deris Y, Alhenc-Gelas F, Gubler MC (1987) Ontogenesis of angiotensin-I converting enzyme in human kidney. Kidney Int 32:684–690CrossRefPubMed

14.

Navar LG (2013) Translational studies on augmentation of intratubular renin-angiotensin system in hypertension. Kidney Int Suppl (2011) 3:321–325CrossRef

15.

Nguyen G, Muller DN (2010) The biology of the (pro)renin receptor. J Am Soc Nephrol 21:18–23CrossRefPubMed

16.

Ohashi N, Isobe S, Ishigaki S, Suzuki T, Iwakura T, Ono M, Fujikura T, Tsuji T, Otsuka A, Ishii Y, Furuse H, Kato A, Ozono S, Yasuda H (2016) Plasma soluble (pro)renin receptor reflects renal damage. PLoS One 11:e0156165CrossRefPubMedPubMedCentral

17.

Oshima Y, Kinouchi K, Ichihara A, Sakoda M, Kurauchi-Mito A, Bokuda K, Narita T, Kurosawa H, Sun-Wada GH, Wada Y, Yamada T, Takemoto M, Saleem MA, Quaggin SE, Itoh H (2011) Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol 22:2203–2212CrossRefPubMedPubMedCentral

18.

Oshima Y, Morimoto S, Ichihara A (2014) Roles of the (pro)renin receptor in the kidney. World J Nephrol 3:302–307CrossRefPubMedPubMedCentral

19.

Pelayo JC, Eisner GM, Jose PA (1981) The ontogeny of the renin-angiotensin system. Clin Perinatol 8:347–359PubMed

20.

Pryde PG, Sedman AB, Nugent CE, Barr M Jr (1993) Angiotensin-converting enzyme inhibitor fetopathy. J Am Soc Nephrol 3:1575–1582PubMed

21.

Ramser J, Abidi FE, Burckle CA, Lenski C, Toriello H, Wen G, Lubs HA, Engert S, Stevenson RE, Meindl A, Schwartz CE, Nguyen G (2005) A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor. Hum Mol Genet 14:1019–1027CrossRefPubMed

22.

Riediger F, Quack I, Qadri F, Hartleben B, Park JK, Potthoff SA, Sohn D, Sihn G, Rousselle A, Fokuhl V, Maschke U, Purfurst B, Schneider W, Rump LC, Luft FC, Dechend R, Bader M, Huber TB, Nguyen G, Muller DN (2011) Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 22:2193–2202CrossRefPubMedPubMedCentral

23.

Schutz S, Le Moullec JM, Corvol P, Gasc JM (1996) Early expression of all the components of the renin-angiotensin-system in human development. Am J Pathol 149:2067–2079PubMedPubMedCentral

24.

Sihn G, Rousselle A, Vilianovitch L, Burckle C, Bader M (2010) Physiology of the (pro)renin receptor: Wnt of change? Kidney Int 78:246–256CrossRefPubMed

25.

Song R, Preston G, Ichihara A, Yosypiv IV (2013) Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS One 8:e63835CrossRefPubMedPubMedCentral

26.

Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM, Yosypiv IV (2016) Prorenin receptor is critical for nephron progenitors. Dev Biol 409:382–391CrossRefPubMed

27.

Song R, Preston G, Yosypiv IV (2013) Ontogeny of the (pro)renin receptor. Pediatr Res 74:5–10CrossRefPubMed

28.

Suzue M, Urushihara M, Nakagawa R, Saijo T, Kagami S (2015) Urinary angiotensinogen level is increased in preterm neonates. Clin Exp Nephrol 19:293–297CrossRefPubMed

29.

Tufro-McReddie A, Gomez RA (1993) Ontogeny of the renin-angiotensin system. Semin Nephrol 13:519–530PubMed

30.

Urushihara M, Kagami S (2011) Urinary angiotensinogen as a biomarker of nephropathy in childhood. International journal of nephrology 2011:206835CrossRefPubMedPubMedCentral

31.

Watanabe N, Bokuda K, Fujiwara T, Suzuki T, Mito A, Morimoto S, Jwa SC, Egawa M, Arai Y, Suzuki F, Sago H, Ichihara A (2012) Soluble (pro)renin receptor and blood pressure during pregnancy: a prospective cohort study. Hypertension 60:1250–1256CrossRefPubMed

32.

Watanabe N, Morimoto S, Fujiwara T, Suzuki T, Taniguchi K, Ando T, Kimura T, Sago H, Ichihara A (2013) Association between soluble (Pro)renin receptor concentration in cord blood and small for gestational age birth: a cross-sectional study. PLoS One 8:e60036CrossRefPubMedPubMedCentral

Titel: (Pro)renin and (pro)renin receptor expression during kidney development in neonates
verfasst von: Tomomasa Terada
Maki Urushihara
Takahiko Saijo
Ryuji Nakagawa
Shoji Kagami
Publikationsdatum: 19.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 2/2017
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-016-2820-9

Neu im Fachgebiet Pädiatrie

23.04.2024 | Typ-1-Diabetes | Nachrichten

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

(Pro)renin and (pro)renin receptor expression during kidney development in neonates

Abstract

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2017

Bladder and bowel dysfunctions in 1748 children referred to pelvic physiotherapy: clinical characteristics and locomotor problems in primary, secondary, and tertiary healthcare settings

A high-vacuum wound drainage system reduces pain and length of treatment for pediatric soft tissue abscesses

European Academy of Paediatrics Statement: Vision zero for child deaths in traffic accidents

European perspective on less invasive surfactant administration—a survey

Therapeutic clowns in pediatrics: a systematic review and meta-analysis of randomized controlled trials-corrigendum

Long-term safety assessment in children who received hydrolyzed protein formulas with Lactobacillus rhamnosus GG: a 5-year follow-up

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie