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Erschienen in: Inflammopharmacology 6/2023

13.10.2023 | Review

Pro-resolving and anti-inflammatory effects of resolvins and protectins in rheumatoid arthritis

verfasst von: Xiurong Zhang, Hongting Zhang

Erschienen in: Inflammopharmacology | Ausgabe 6/2023

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Abstract

Rheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in overall quality of life. The global prevalence of pain as a primary symptom in RA is influenced by the interplay between inflammation and its resolution. The identification of a family of lipid mediators known as specialized pro-resolving mediators (SPM)s has contributed to the progress of our comprehension of inflammatory conditions. SPMs have been observed to trigger the process of inflammation resolution, thereby reinstating the homeostasis of the inflammatory response. Autacoids are synthesized through the stereo-selective transformation of essential fatty acids, resulting in molecules dynamically modulated during inflammation and possessing strong immunoregulatory properties. This review delves into the available evidence that supports the involvement of certain SPM as protective lipids, biomarkers with potential, and therapeutic targets in the context of RA.
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Metadaten
Titel
Pro-resolving and anti-inflammatory effects of resolvins and protectins in rheumatoid arthritis
verfasst von
Xiurong Zhang
Hongting Zhang
Publikationsdatum
13.10.2023
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 6/2023
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01343-5

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