Electronic supplementary material
What is Known:
• Cow’s milk protein allergy (CMPA) is one of the commonest food allergies in children. CMPA is associated with significant socioeconomic burden.
• Elimination diet and extensively hydrolyzed formula is the mainstay of the management of CMPA.
What is New:
• This first systematic review of randomized controlled trials shows that probiotics as an adjuvant can lead to earlier acquisition of tolerance to CMP in children at 36 months of age. However, the evidence is low quality and influenced by data from one large study.
• Probiotic supplementation was not associated with earlier resolution of hematochezia.