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Archives of Virology

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01.04.2020 | Brief Report

Production of immunogenic recombinant L1 protein of bovine papillomavirus type 9 causing teat papillomatosis

verfasst von: Satoko Watanabe, Tomoyuki Shibahara, Kiyohiko Andoh, Shinichi Hatama, Masaji Mase

Erschienen in: Archives of Virology | Ausgabe 6/2020

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Abstract

Bovine papillomavirus type 9 (BPV9) is a causative agent of severe teat papillomatosis. Considering the lack of efficient BPV culture methods, recombinant proteins such as virus-like particles developed through genetic engineering may serve as a useful tool for developing effective vaccines against BPV infection. In this study, we successfully produced immunogenic particles composed of recombinant L1 protein of BPV9 (rBPV9-L1), using a baculovirus expression system. rBPV9-L1-immunized mice produced BPV9-specific IgG, which did not cross-react with BPV type 6, which is another causative agent of teat papillomatosis. Hence, immunogenic rBPV9-L1 is potentially applicable as a vaccine candidate for teat papillomatosis.

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Titel: Production of immunogenic recombinant L1 protein of bovine papillomavirus type 9 causing teat papillomatosis
verfasst von: Satoko Watanabe
Tomoyuki Shibahara
Kiyohiko Andoh
Shinichi Hatama
Masaji Mase
Publikationsdatum: 01.04.2020
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 6/2020
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-020-04612-8

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Production of immunogenic recombinant L1 protein of bovine papillomavirus type 9 causing teat papillomatosis

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