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Planta Med 2012; 78(8): 821-827
DOI: 10.1055/s-0031-1298376
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Cycloartane Triterpenoids from Cassia occidentalis

Shi-Fei Li1 , 2 , Ying-Tong Di1 , Rong-Hua Luo3 , Yong-Tang Zheng3 , Yue-Hu Wang1 , Xin Fang1 , Yu Zhang1 , Ling Li4 , Hong-Ping He1 , Shun-Lin Li1 , Xiao-Jiang Hao1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Graduate University of Chinese Academy of Sciences, Beijing, P. R. China
  • 3Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 4Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, Yunnan, P. R. China
Further Information

Publication History

received October 28, 2011 revised February 22, 2012

accepted February 24, 2012

Publication Date:
12 March 2012 (online)

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Abstract

A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I–V (3–7), together with sixteen known compounds. The structures of the isolated compounds were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and chemical methods. Compounds 2 and 5 showed modest anti-HIV-1 activities with EC50 values of 2.23 µM and 4.36 µM, respectively, in comparison to the positive control.

Key words

Cassia occidentalis - Leguminosae - cycloartane triterpenoids - cycloccidentalic acids A and B - cycloccidentalisides I–V

Supporting Information

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Prof. Dr. Xiao-Jiang Hao

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

132 Lanhei Road

Heilongtan 650204, Kunming

P. R. China

Phone: +86 871 5 22 32 63

Fax: +86 871 5 22 30 70

Email: haoxj@mail.kib.ac.cn

Shun-Lin Li

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

132 Lanhei Road

Heilongtan 650204, Kunming

P. R. China

Phone: +86 871 5 22 32 63

Fax: +86 871 5 22 30 70

Email: lisl@mail.kib.ac.cn

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