Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial

 

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Background and study aims: Olympus recently developed a new algorithm called Omni mode that discards redundant video capsule endoscopy (VCE) images. The current study aimed to demonstrate the non-inferiority of the Omni mode in terms of true positives (TPs) and the superiority of the Omni mode with regard to reading time against a control (ordinary ES-10 system).

Patients and methods: This multicenter prospective study included 40 patients with various small bowel diseases. VCE images were evaluated by 7 readers and 3 judging committee members. Two randomly allocated readers assessed the VCE images obtained using the 2 modalities for each patient. The order of the modalities was switched between the 2 readers and the interval between readings by the same reader was 2 weeks. The judging committee predefined clinically relevant lesions as major lesions and irrelevant lesions as minor lesions. The number of TPs for major and minor lesions and the reading times were compared between the modalities. The predefined non-inferiority margin for the TP ratio of the Omni mode compared with the control was 0.9.

Results: The estimated TP ratios and 95 % confidence intervals for total, major, and minor lesions were 0.87 (0.80 – 0.95), 0.93 (0.83 – 1.04), and 0.83 (0.74 – 0.94), respectively. Although non-inferiority was not demonstrated, the rate of detection of major lesions was not significantly different between the modalities. The reading time was significantly lower when using the Omni mode than when using the control.

Conclusions: The Omni mode may be only appropriate for the assessment of major lesions.

• References

• 1 Triester SL, Leighton JA, Leontiadis GI et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding. Am J Gastroenterol 2005; 100: 2407-2418
  CrossrefPubMedGoogle Scholar
• 2 Min YW, Kim JS, Jeon SW et al. Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis. Endoscopy 2014; 46: 59-65
  Article in Thieme ConnectPubMedGoogle Scholar
• 3 Papadakis KA, Lo SK, Fireman Z et al. Wireless capsule endoscopy in the evaluation of patients with suspected or known Crohn’s disease. Endoscopy 2005; 37: 1018-1022
  Article in Thieme ConnectPubMedGoogle Scholar
• 4 Waterman M, Gralnek IM. Capsule endoscopy of the esophagus. J Clin Gastroenterol 2009; 43: 605-612
  CrossrefPubMedGoogle Scholar
• 5 Rey JF, Ogata H, Hosoe N et al. Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard videoendoscope. Gastrointest Endosc 2012; 75: 373-381
  CrossrefPubMedGoogle Scholar
• 6 Spada C, Hassan C, Munoz-Navas M et al. Second-generation colon capsule endoscopy compared with colonoscopy. Gastrointest Endosc 2011; 74: 581-589.e581
  CrossrefPubMedGoogle Scholar
• 7 Hosoe N, Rey JF, Imaeda H et al. Evaluations of capsule endoscopy software in reducing the reading time and the rate of false negatives by inexperienced endoscopists. Clin Res Hepatol Gastroenterol 2012; 36: 66-71
  CrossrefPubMedGoogle Scholar
• 8 Shiotani A, Honda K, Kawakami M et al. Evaluation of RAPID((R)) 5 Access software for examination of capsule endoscopies and reading of the capsule by an endoscopy nurse. J Gastroenterol 2011; 46: 138-142
  CrossrefPubMedGoogle Scholar
• 9 Subramanian V, Mannath J, Telakis E et al. Efficacy of new playback functions at reducing small-bowel wireless capsule endoscopy reading times. Dig Dis Sci 2012; 57: 1624-1628
  CrossrefPubMedGoogle Scholar
• 10 Stein AC, Appannagari A, Habib I et al. A rapid and accurate method to detect active small bowel gastrointestinal bleeding on video capsule endoscopy. Dig Dis Sci 2014; 59: 2503-2507
  CrossrefPubMedGoogle Scholar
• 11 D'Halluin PN, Delvaux M, Lapalus MG et al. Does the “Suspected Blood Indicator” improve the detection of bleeding lesions by capsule endoscopy?. Gastrointest Endosc 2005; 61: 243-249
  CrossrefPubMedGoogle Scholar
• 12 Liangpunsakul S, Mays L, Rex DK. Performance of Given suspected blood indicator. Am J Gastroenterol 2003; 98: 2676-2678
  CrossrefPubMedGoogle Scholar
• 13 Koulaouzidis A, Smirnidis A, Douglas S et al. QuickView in small-bowel capsule endoscopy is useful in certain clinical settings, but QuickView with Blue Mode is of no additional benefit. Eur J Gastroenterol Hepatol 2012; 24: 1099-1104
  CrossrefPubMedGoogle Scholar
• 14 Krystallis C, Koulaouzidis A, Douglas S et al. Chromoendoscopy in small bowel capsule endoscopy: Blue mode or Fuji Intelligent Colour Enhancement?. Dig Liver Dis 2011; 43: 953-957
  CrossrefPubMedGoogle Scholar
• 15 Nakamura M, Ohmiya N, Miyahara R et al. Usefulness of flexible spectral imaging color enhancement (FICE) for the detection of angiodysplasia in the preview of capsule endoscopy. Hepato-gastroenterology 2012; 59: 1474-1477
  PubMedGoogle Scholar
• 16 Westerhof J, Koornstra JJ, Weersma RK. Can we reduce capsule endoscopy reading times?. Gastrointest Endosc 2009; 69: 497-502
  CrossrefPubMedGoogle Scholar
• 17 Pohl J, Aschmoneit I, Schuhmann S et al. Computed image modification for enhancement of small-bowel surface structures at video capsule endoscopy. Endoscopy 2010; 42: 490-492
  Article in Thieme ConnectPubMedGoogle Scholar