Sipandinolide: A Butenolide Including a Novel Type of Carbon Skeleton from Siparuna andina

Kristina Jenett-Siems; Karsten Siems; Jasmin Jakupovic; Pablo N. Solis; Mahabir P. Gupta; Frank P. Mockenhaupt; Ulrich Bienzle; Eckart Eich

doi:10.1055/s-2000-14898

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Planta Med 2000; 66(4): 384-385
DOI: 10.1055/s-2000-14898

Letter

Georg Thieme Verlag Stuttgart · New York

Sipandinolide: A Butenolide Including a Novel Type of Carbon Skeleton from Siparuna andina

Kristina Jenett-Siems¹ , Karsten Siems² , Jasmin Jakupovic , Pablo N. Solis³ , Mahabir P. Gupta³ , Frank P. Mockenhaupt⁴ , Ulrich Bienzle⁴ , Eckart Eich¹

¹Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Berlin, Germany
²AnalytiCon AG, Potsdam, Germany
³Centro de Investigationes Farmacognosticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panama, Panama, Republica de Panama
⁴Institut für Tropenmedizin, Medizinische Fakultät Charité der Humboldt Universität zu Berlin, Berlin, Germany

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Publication History

June 22, 1999

July 17, 1999

Publication Date:
31 December 2000 (online)

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Abstract

From a lipophilic extract of leaves of Siparuna andina (Monimiaceae), which exhibited antiplasmodial activity in vitro, two new compounds have been isolated: sipandinolide ( 1), a compound with a novel type of carbon skeleton and (-)-cis-3-acetoxy-4',5,7-trihydroxyflavanone ( 2). Their structures were established by spectroscopic methods; 2 showed moderate antiplasmodial activity whereas 1 was inactive.

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