Sterols, Triterpenes and Biflavonoids of Viburnum jucundum and Cytotoxic Activity of Ursolic Acid

 

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Abstract

The triterpenes ursolic acid (1), 27-p-Z-coumaroyloxyursolic acid (2), 27-p-E-coumaroyloxyursolic acid, α-amyrine-3-palmitate and lupeol-3-palmitate were isolated through a bioactivity-guided fractionation from the acetonic extract of the aerial parts of Viburnum jucundum Morton in addition to amentoflavone, an epimeric mixture at C-2 of 2,3-dihydroamentoflavone, β-sitosterol and β-sitosteryl glucopyranoside. Ursolic acid (1) was the only constituent that exhibited cytotoxic activity toward three human cancer cell lines in culture. This is the first phytochemical and cytotoxic analysis performed to this plant species.

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Dr. María Yolanda Rios

Centro de Investigaciones Químicas

Universidad Autónoma del Estado de Morelos

Av. Universidad 1001

Chamilpa 62210

Cuernavaca, Mor.

México

Fax: (+5273) 29 79 98

Email: yrios@iqunam.iquimica.unam.mx.

Phone: Tel. (+5273) 29 70 00 ext. 6024