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Planta Med 2004; 70(4): 370-373
DOI: 10.1055/s-2004-818952
Letter
© Georg Thieme Verlag Stuttgart · New York

Polysaccharides from Hibiscus sabdariffa Flowers Stimulate Proliferation and Differentiation of Human Keratinocytes

C. Brunold1 , A. Deters1 , F. Knoepfel-Sidler1 , J. Hafner2 , B. Müller1 , A. Hensel1
  • 1University of Applied Science Wädenswil, Pharmaceutical Biotechnology, Wädenswil, Switzerland
  • 2Universitätsspital Zürich, Dermatology, Zürich, Switzerland
Further Information

Publication History

Received: September 10, 2003

Accepted: December 13, 2002

Publication Date:
19 April 2004 (online)

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Abstract

Raw polysaccharides, previously described in detail, were isolated from the flowers of Hibiscus sabdariffa L. and fractionated by ion exchange chromatography into one neutral and three acidic subfractions. Raw polysaccharides and all acidic subfractions caused a strong induction of proliferation of human keratinocytes (HaCaT) of up to 40 %, while the neutral polymers were ineffective. While mitochondrial activity was not influenced, raw polysaccharides induced early differentiation of primary natural human keratinocytes, as determined by involucrin formation.

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Prof. Dr. A. Hensel

University of Applied Science Wädenswil

Pharmaceutical Biotechnology

Gruental

8820 Wädenswil

Switzerland

Phone: +41-1789-9670

Fax: +41-1789-9950

Email: a.hensel@hsw.ch

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